AIDS is one of the worst pathologies of our time. Unfortunately, and despite a very large number of studies, the mechanisms of HIV pathogenesis in humans are still poorly understood. Nonpathogenic SIV infection of African nonhuman primates represents a ...
ABSTRACT While Tregs maintain self-tolerance and inhibit antitumor responses, T helper (Th)17 cells may enhance inflammatory and antitumor responses. The balance between these two important T-cell subsets has been skewed in many immunopathologic ...
Psoriasis is a chronic skin disorder driven by IL-23 and the downstream T-helper cell 17 (Th17) pathway. Tildrakizumab is a humanized monoclonal antibody selectively targeting the p19 subunit of IL-23, a key cytokine for Th17 cells. Here, we provide an ...
Graft-versus-host disease (GvHD), a major complication following allogeneic hematopoietic stem cell transplantation, is mediated by donor-derived T cells. On activation with alloantigens expressed on host antigen-presenting cells, naive CD4+ T cells ...
Chronic atrophic gastritis, a precancerous change for gastric cancer, shows a loss of appropriate glands, Helicobacter pylori infection and autoimmune gastritis being the two main etiologic factors. While H. pylori eradication is the mandatory treatment ...
Evaluation of: Wedebye Schmidt EG, Larsen HL, Kristensen N et al. Th17 cell induction and effects of IL-17A and IL-17F blockade in experimental colitis. Inflamm. Bowel Dis. 19(8), 1567–1576 (2013). The contribution of Th17 cells to the development of ...
Aim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor‐infiltrating T cells. Materials & methods:MAGE‐C1/CT‐7, MAGEA3/6, NY‐ESO‐1, LAGE‐1 and GAGE expression were ...