It has long been known that obesity modestly increases the risk of prostate cancer mortality. Only recently, however, have studies examined whether this association is due to an increased risk of aggressive disease and/or worse outcomes following initial ...
The aim of this review is to present an overview of the management of urge urinary incontinence and stress urinary incontinence. The evaluation of incontinence and options for surgical management of both urge and stress urinary incontinence will be ...
Evaluation of: Hirsch FR, Varella-Garcia M, Bunn PA Jr et al.: Molecular predictors of outcome with gefitinib in a Phase III placebo-controlled study in advanced non-small-cell lung cancer. J. Clin. Oncol. 24(31), 5034–5042 (2006) [1]. In this article, we ...
The purpose of this review is to present current therapeutic approaches to brain metastases in elderly patients. With increases in life expectancy and advances in neuroimaging techniques, the incidence of elderly patients with brain metastases is ...
Achieving safe prescribing in frail older people is difficult owing to age-related physiological changes, multiple comorbidities, multiple medication use and a higher risk of adverse drug events (ADEs). Among people aged 65 years and over, 7–25% are ...
Evaluation of: Dordea M, Jones R, Nicolas AP et al.: Surgery for breast cancer in the elderly – how relevant? Breast 20(3), 212–214 (2011). Breast cancer is a common disease in older women. Traditionally, it was believed that older women had less ...
Adult Spinal Deformity (ASD) is a complex 3D entity associating various factors including age-related changes. While coronal deformation is well understood, sagittal plane evaluation of the normal and aging spine with associated deformity must be taken ...
The selection of a suitable candidate for hip arthroplasty involves several important patient-specific considerations. Advanced age may be considered a relative contraindication for elective surgery, and may unfortunately cause a stereotypical dismissal ...
Aim: Inflammatory biomarkers are associated with aging and disease-specific outcomes. We propose neutrophil–lymphocyte ratio (NLR) informs survival in a noncancer-bearing population. Patients & methods: Retrospective cohort study of patients with a ...
Aim: To investigate the relationship between urinary pH (UpH) and clinical outcome in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. Methods: Data of 2081 patients with ST-segment elevation ...
Background: Inflammatory breast cancer (IBC) is uncommon, aggressive and associated with poor survival outcomes. The lack of prognostic biomarkers and therapeutic targets specific to IBC is an added challenge for clinical practice and research. ...
SUMMARY: Proton therapy is a novel technique for treating pediatric malignancies. As a tool to reduce normal-tissue dose, it has the potential to decrease late toxicity. Although proton therapy has been used for over five decades, most pediatric ...
Ischemic heart disease and stroke are the leading causes of death in the world currently. Both of these conditions are primarily caused by atherosclerosis, the underlying pathophysiology of which is the deposition of lipid, specifically low-density ...
Aim: The aim of the project was to conduct a systematic review of meta-analyses of supervised, home-based or telemedicine-based exercise cardiac rehabilitation (CR) published between July 2011 and April 2018. Materials & methods: Evidence on mortality, ...
Background: The association of weight change and short-term readmission in patients hospitalized for heart failure (HF) has not been well studied. Methods: We collected clinical and weight data from patients admitted with decompensated HF to a single ...
Aim: Bifurcation-PCI is performed frequently, although without extensive evidence to back up a definitive solution for its complexity. We set out to identify factors associated with 1- and 12-month mortality after bifurcation-PCI between 2017 and 2021 in ...
Over the past decade, minimally invasive cardiothoracic surgery (MICS) has grown in popularity. This growth has been driven, in part, by a desire to translate many of the observed benefits of minimal access surgery, such as decreased pain and reduced ...
Cardiac biomarkers assist in the diagnosis of and risk stratification in acute coronary syndromes. In ST-elevation myocardial infarction (STEMI), rapid diagnosis and initiation of reperfusion via primary percutaneous coronary intervention or fibrinolysis ...