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Research Article

Combined photothermal and photodynamic therapy by hyaluronic acid-decorated polypyrrole nanoparticles

    Tuan Hiep Tran§,†

    Department for Management of Science & Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam

    Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam

    College of Pharmacy, Yeungnam University, 214–211, Dae-Dong, Gyeongsan 712-749, South Korea

    ,
    Hanh Thuy Nguyen

    College of Pharmacy, Yeungnam University, 214–211, Dae-Dong, Gyeongsan 712-749, South Korea

    Authors contributed equally.

    Search for more papers by this author

    ,
    Thi Thu Phuong Tran

    The Institute of Molecular Genetics of Montpellier, CNRS, Montpellier, France

    ,
    Sae Kwang Ku

    College of Korean Medicine, Daegu Haany University, Gyeongsan 712-715, South Korea

    ,
    Jee-Heon Jeong

    College of Pharmacy, Yeungnam University, 214–211, Dae-Dong, Gyeongsan 712-749, South Korea

    ,
    Han-Gon Choi

    College of Pharmacy, Hanyang University, 55, Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea

    ,
    Chul Soon Yong

    *Author for correspondence:

    E-mail Address: csyong@yu.ac.kr

    College of Pharmacy, Yeungnam University, 214–211, Dae-Dong, Gyeongsan 712-749, South Korea

    &
    Jong Oh Kim

    **Author for correspondence:

    E-mail Address: jongohkim@yu.ac.kr

    College of Pharmacy, Yeungnam University, 214–211, Dae-Dong, Gyeongsan 712-749, South Korea

    Published Online:https://doi.org/10.2217/nnm-2016-0438

    Aim: To develop a nanoparticle-based platform using polypyrrole and IR-780 for effective combined photothermal and photodynamic therapy. Materials & methods: IR-780 was loaded in a poly(lactic-co-glycolic acid) core, decorated with polypyrrole shells and hyaluronic acid (IPPH). Physicochemical properties and in vitro and in vivo anticancer effects of these nanoparticles were evaluated. Results: The resulting IPPHs were spherical, small and negatively charged. Under near-infrared laser irradiation, the IPPHs generated reactive oxygen species and heat and synergistically improved therapeutic efficacy. The antitumor effects were confirmed by in vitro cellular reactive oxygen species detection and cytotoxicity assays, and in vivo in a xenograft tumor model, with no damage to body organs. Conclusion: Our results indicate the potential of applying IPPH in oncology nanomedicine.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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