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Short Communication

Cost–effectiveness analysis of atezolizumab plus nab-paclitaxel for untreated metastatic triple-negative breast cancer

    Jiahao Li‡

    College of Pharmacy, Jinan University, Guangzhou 510632, China

    ‡Authors contributed equally

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    ,
    Tiantian Zhang‡

    College of Pharmacy, Jinan University, Guangzhou 510632, China

    International Cooperative Laboratory of Traditional Chinese Medicine Modernization & Innovative Drug Development of Chinese Ministry of Education (MOE), Jinan University, Guangzhou 510632, China

    Guangzhou Huabo Biopharmaceutical Research Institute, 510010, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Peiyao Lu

    College of Pharmacy, Jinan University, Guangzhou 510632, China

    ,
    Jianfu Zhao

    Department of Oncology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China

    ,
    Lin Chen

    **Author for correspondence:

    E-mail Address: 280266944@qq.com

    Drug Clinical Trial Institution, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China

    &
    Jie Jiang

    *Author for correspondence:

    E-mail Address: jiangjie218@126.com

    College of Pharmacy, Jinan University, Guangzhou 510632, China

    International Cooperative Laboratory of Traditional Chinese Medicine Modernization & Innovative Drug Development of Chinese Ministry of Education (MOE), Jinan University, Guangzhou 510632, China

    Dongguan Institute of Jinan University, Dongguan 523808, China

    Published Online:https://doi.org/10.2217/imt-2020-0036

    Aim: To evaluate the cost–effectiveness of atezolizumab plus nab-paclitaxel (ANP) in the first-line treatment of metastatic triple-negative breast cancer (TNBC). Materials & methods: We developed a Markov model to evaluate the cost and effectiveness of ANP versus nab-paclitaxel in the first-line treatment of metastatic TNBC. Lifetime costs, life-years (LYs) and quality-adjusted LYs (QALYs) were estimated. Results: ANP provided an additional 0.16 QALYs (0.24 LYs) compared with nab-paclitaxel in intention-to-treat population. The corresponding incremental cost–effectiveness ratio was $786,131 per QALY gained. However, the incremental cost–effectiveness ratio decreased to $361,218 per QALY gained in the PD-L1 positive subgroup analysis. Conclusion: From the perspective of a US-payer, ANP is estimated not to be cost-effective in the first-line treatment of metastatic TNBC.

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