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Efficacy and safety of bevacizumab in patients with low-grade serous ovarian cancer

    Cengiz Karacin

    *Author for correspondence:

    E-mail Address: cengizkaracin@yahoo.com

    Department of Medical Oncology, University of Health Sciences, Dr Abdurrahman Yurtaslan Ankara Oncology Training & Research Hospital, Ankara, Turkey

    ,
    Veli Sunar

    Depatment of Medical Oncology, Losante Children & Adult Hospital, Ankara, Turkey

    ,
    Zuhat Urakci

    Departmen of Medical Oncology, Dicle University, Diyarbakir, Turkey

    ,
    Ali Yilmaz

    Department of Medical Oncology, Atatürk University Training Hospital, Erzurum, Turkey

    ,
    Murat Ayhan

    Department of Medical Oncology, Kartal Training & Research Hospital, Istanbul, Turkey

    ,
    Mustafa Ersoy

    Department of Medical Oncology, Osmangazi University, Eskisehir, Turkey

    ,
    Deniz Can Guven

    Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey

    ,
    Ismail Erturk

    Department of Medical Oncology, University of Health Sciences, Gulhane Training & Research Hospital, Ankara, Turkey

    ,
    Yasin Durmus

    Department of Gynecology, Etlik Zubeyde Hanim Training & Research Hospital, Ankara, Turkey

    ,
    Pinar Karacin

    Department of Gynecology, Etlik Zubeyde Hanim Training & Research Hospital, Ankara, Turkey

    ,
    Nurettin Boran

    Department of Gynecology, Etlik Zubeyde Hanim Training & Research Hospital, Ankara, Turkey

    ,
    Yaprak Engin Ustun

    Department of Gynecology, Etlik Zubeyde Hanim Training & Research Hospital, Ankara, Turkey

    ,
    Mutlu Meydan

    Department of Gynecology, Zekai Tahir Burak Training & Research Hospital, Ankara, Turkey

    ,
    Mutlu Dogan

    Department of Medical Oncology, University of Health Sciences, Dr Abdurrahman Yurtaslan Ankara Oncology Training & Research Hospital, Ankara, Turkey

    ,
    Berna Oksuzoğlu

    Department of Medical Oncology, University of Health Sciences, Dr Abdurrahman Yurtaslan Ankara Oncology Training & Research Hospital, Ankara, Turkey

    ,
    Ozturk Ates

    Department of Medical Oncology, University of Health Sciences, Dr Abdurrahman Yurtaslan Ankara Oncology Training & Research Hospital, Ankara, Turkey

    ,
    Mustafa Karaca

    Department of Medical Oncology, Antalya Training & Research Hospital, Antalya, Turkey

    ,
    Dogan Uncu

    Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, Turkey

    ,
    Yakup Ergun

    Department of Medical Oncology, Antalya City Hospital, Antalya, Turkey

    &
    Zafer Arik

    Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey

    Published Online:https://doi.org/10.2217/fon-2023-0763

    Aim: To investigate the efficacy and safety of bevacizumab in patients with recurrent low-grade serous ovarian carcinoma. Materials & methods: The data of patients who received at least two cycles of bevacizumab in combination with chemotherapy were retrospectively recorded. Results: The median age of 51 patients was 56 (range: 33–75) years. The complete response rate was 10.4% and the partial response rate was 43.7%. The objective response rate was 54.1%. Median progression-free survival was 15.9 months (95% CI: 9.1–22.6) and median overall survival was 42.5 months (95% CI: 37.2–47.8). Conclusion: Bevacizumab with chemotherapy is an effective option for treating recurrent ovarian low-grade serous carcinoma.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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