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The relationship between serum lactate dehydrogenase level and mortality in critically ill patients

    Dan Su‡

    Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Jiamei Li‡

    Department of Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Jiajia Ren

    Department of Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    ,
    Ya Gao

    Department of Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    ,
    Ruohan Li

    Department of Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    ,
    Xuting Jin

    Department of Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    ,
    Jingjing Zhang

    Department of Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    &
    Gang Wang

    *Author for correspondence: Tel.: +86 029 8767 9633;

    E-mail Address: gang_wang@xjtu.edu.cn

    Department of Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    Published Online:https://doi.org/10.2217/bmm-2020-0671

    Background: To assess the association between serum lactate dehydrogenase (LDH) levels and mortality in intensive care unit patients. Materials & methods: A total of 1981 patients in the eICU Collaborative Research Database were divided into four groups according to quartiles of LDH levels. Logistic regressions were performed. Results: Elevated LDH levels were significantly associated with higher mortality (intensive care unit mortality: Q2 vs Q1: 1.046 [0.622–1.758]; Q3 vs Q1: 1.667 [1.029–2.699]; and Q4 vs Q1: 1.760 [1.092–2.839]). Similar results persisted in patients with different acute physiology and chronic health evaluation IV scores, and with or without sepsis. Conclusion: The serum LDH level may aid in the early identification of mortality risk in critically ill patients.

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