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Systematic Review

PD-L1 for selecting non-small-cell lung cancer patients for first-line immuno-chemotherapy combination: a systematic review and meta-analysis

    Antonio Rossi

    Division of Medical Oncology, Department of Onco-Hematology, Scientific Institute for Research & Health Care (IRCCS) “Casa Sollievo della Sofferenza”, San Giovanni Rotondo (FG), Italy

    ,
    Vincenzo Di Noia

    Comprehensive Cancer Center, Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Roma, Italy

    ,
    Anastasios Gkountakos

    Department of Diagnostics & Public Health, University & Hospital Trust of Verona, Verona, Italy

    ,
    Ettore D’Argento

    Comprehensive Cancer Center, Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy

    ,
    Giulia Sartori

    Department of Medicine, Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University & Hospital Trust of Verona, Italy

    ,
    Emanuele Vita

    Comprehensive Cancer Center, Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Roma, Italy

    ,
    Sara Monteverdi

    Department of Medicine, Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University & Hospital Trust of Verona, Italy

    ,
    Fiorella Lombardo

    Department of Medicine, Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University & Hospital Trust of Verona, Italy

    ,
    Roberto Iacovelli

    Comprehensive Cancer Center, Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy

    ,
    Luisa Carbognin

    Department of Medicine, Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University & Hospital Trust of Verona, Italy

    Department of Woman & Child Health, Division of Gynecologic Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy

    ,
    Isabella Sperduti

    Biostatistics, IRCCS Regina Elena National Cancer Institute, Roma, Italy

    ,
    Michele Milella

    Department of Medicine, Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University & Hospital Trust of Verona, Italy

    ,
    Giampaolo Tortora

    Comprehensive Cancer Center, Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Roma, Italy

    ,
    Emilio Bria‡

    *Author for correspondence: Tel.: +39 063 015 4953; Fax: +39 063 015 4838;

    E-mail Address: emilio.bria@unicatt.it

    Comprehensive Cancer Center, Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Roma, Italy

    ‡Authors contributed equally

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    &
    Sara Pilotto‡

    Department of Medicine, Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University & Hospital Trust of Verona, Italy

    ‡Authors contributed equally

    Search for more papers by this author

    Published Online:https://doi.org/10.2217/imt-2018-0198

    Aim: With the final aim to explore the first-line treatment options for non-small-cell lung cancer (NSCLC) patients, we performed a systematic review and literature-based meta-analysis of available clinical trials exploring immunotherapy in combination versus standard histology-based chemotherapy. Materials & methods: We evaluated interactions according to type of treatment-add-on strategy: immunotherapy in combination versus standard chemotherapy-based regimens. Hazard ratio (HR) for overall survival (OS) and progression-free survival (PFS) were extracted and cumulated. Results: Seven trials (4278 patients) were included. The addition of immunotherapy to standard chemotherapy-based regimens significantly increased OS (HR 0.74; p = 0.001) and PFS (HR 0.61; p < 0.0001) compared with standard-of-care in NSCLC patients in first-line setting. Conclusion: Immunotherapy-based regimens constantly improved OS and PFS compared with chemotherapy in first-line treatment of nononcogene-addicted NSCLC.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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