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Diagnostic value of PIVKA-II in detecting hepatocellular carcinoma

    Xiao-Qiong Tang

    Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China

    Authors contributed equally

    Search for more papers by this author

    ,
    Hong Li

    Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China

    Authors contributed equally

    Search for more papers by this author

    ,
    Li-Bo Yan

    Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China

    ,
    Ling-Yun Zhou

    Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China

    ,
    En-Qiang Chen

    Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China

    ,
    Miao Liu

    Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China

    ,
    Dong-Mei Zhang

    Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China

    &
    Hong Tang

    *Author for correspondence:

    E-mail Address: htang6198@hotmail.com

    Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China

    Published Online:https://doi.org/10.2217/fvl-2017-0017

    Aim: Evaluation of prothrombin induced by vitamin K absence-II (PIVKA-II) in detecting hepatitis B virus-associated hepatocellular carcinoma (HCC). Materials & methods: PIVKA-II and AFP levels were measured in 366 Chinese subjects (176 HCC, 98 liver cirrhosis and 92 noncirrhotic chronic hepatitis B patients). Results: PIVKA-II showed a sensitivity of 82.4% and a specificity of 95.9% at a cut-off value of 40.5 mAU/ml versus 73.9 and 82.9% for AFP at a cut-off value of 12.3 ng/ml for differentiating HCC from non-HCC. In detecting small-sized HCC (<3 cm), the sensitivity of PIVKA-II, AFP and their combination was 63.6, 75.8 and 84.8%, respectively. Conclusion: PIVKA-II was more efficient than AFP in detecting HBV-associated HCC, and their combination could improve the detection sensitivity.

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