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A pharmacogenomic study revealed an association between SLC6A4 and risperidone-induced weight gain in Chinese Han population

    Fang Wang

    Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China

    Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China

    Beijing Children’s Hospital, Capital Medical University, Beijing 100191, China

    Authors contributed equally

    Search for more papers by this author

    ,
    Weifeng Mi

    Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China

    Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China

    Authors contributed equally

    Search for more papers by this author

    ,
    Wenbin Ma

    Jinzhou Kangning Hospital, Jinzhou, Liaoning 121013, China

    ,
    Cuicui Ma

    Jinzhou Kangning Hospital, Jinzhou, Liaoning 121013, China

    ,
    Yongfeng Yang

    Department of Psychiatry of the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, China

    Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang, Henan 453002, China

    ,
    Hongxing Zhang

    Department of Psychiatry of the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, China

    Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang, Henan 453002, China

    ,
    Bo Du

    Hebei Mental Health Center, Baoding, Hebei 071000, China

    ,
    Keqing Li

    Hebei Mental Health Center, Baoding, Hebei 071000, China

    ,
    Chenxing Liu

    Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China

    Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China

    ,
    Lifang Wang

    Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China

    Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China

    ,
    Tianlan Lu

    Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China

    Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China

    ,
    Hongyan Zhang

    Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China

    Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China

    ,
    Luxian Lv

    Department of Psychiatry of the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, China

    Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang, Henan 453002, China

    ,
    Dai Zhang

    *Authors for correspondence:

    E-mail Address: dryue@bjmu.edu.cn

    Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China

    Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China

    &
    Weihua Yue

    Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China

    Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China

    Published Online:https://doi.org/10.2217/pgs.15.133

    Aim: We carried out a pharmacogenomic study in order to identify susceptible genes for antipsychotics induced weight gain within the Chinese Han population. Materials & methods: We enrolled 216 patients with schizophrenia in our study. All of them underwent risperidone monotherapy, and fulfilled 4-week follow-up. Weight gain was measured before treatment and 4 weeks later. Seven hundred and sixty-eight SNPs from 85 genes were calculated for association with weight gain percentage. Results: Fifty-seven SNPs located at 16 genes with a p-value less than 0.05.4 SNPs located on serotonin transporter gene (solute carrier family 6, member 4, SLC6A4) remained significant after multitest correction (rs3813034, p = 0.000357, q = 0.08, rs1042173, rs4325622, rs9303628, p = 0.000451, q = 0.08). Conclusion:SLC6A4 might be susceptible gene for risperidone-induced weight gain within the Chinese Han population.

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