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HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population

    Fanping Yang

    Huashan Hospital, Fudan University, Shanghai, China

    Authors contributed equally

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    ,
    Bo Gu

    Children's Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, China

    Authors contributed equally

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    ,
    Lirong Zhang

    Department of Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou, China

    Authors contributed equally

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    ,
    Jiekun Xuan

    Children's Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, China

    Current address: National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA

    ,
    Heng Luo

    University of Arkansas at Little Rock/University of Arkansas for Medical Sciences Joint Bioinformatics Program, 2801 S. University Avenue, Little Rock, AR 72204, USA

    ,
    Peng Zhou

    Center of Bioinformatics (COBI) & Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science & Technology, University of Electronic Science & Technology of China, Chengdu 610054, China

    ,
    Qinyuan Zhu

    Huashan Hospital, Fudan University, Shanghai, China

    ,
    Sijia Yan

    Children's Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, China

    ,
    Sheng-an Chen

    Huashan Hospital, Fudan University, Shanghai, China

    ,
    Zhihao Cao

    Huashan Hospital, Fudan University, Shanghai, China

    ,
    Jinhua Xu

    Huashan Hospital, Fudan University, Shanghai, China

    ,
    Qinghe Xing§

    Children's Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, China

    §Authors contributed equally

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    &
    Xiaoqun Luo

    Huashan Hospital, Fudan University, Shanghai, China

    §Authors contributed equally

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    Published Online:https://doi.org/10.2217/pgs.14.69

    Aim: Salazosulfapyridine (SASP) frequently causes several adverse reactions, such as drug rash with eosinophilia and systemic symptoms (DRESS). This study aims to assess whether there is an association between SASP-induced DRESS and HLA-A, -B and -C alleles in the Chinese Han population. Subjects & methods: We performed an association study of six subjects with SASP-induced DRESS, 30 SASP-tolerant patients and 283 general subjects from the human MHC database, all of whom are Han Chinese. Results: The frequency of the SASP-induced DRESS patients carrying the HLA-B*13:01 allele is 66.67% (4/6). It is significantly higher compared with the general Chinese Han population (15.19%, 43/283; odds ratio: 11.16; p = 0.007) or with the SASP-tolerant patients (13.33%, 4/30; odds ratio: 13.00; p = 0.004). Conclusion: These findings show for the first time that in the Chinese Han population, HLA-B*13:01 is associated with SASP-induced DRESS. HLA-B*13:01 might serve as a potential genetic marker for reducing the prevalence of SASP-induced DRESS.

    Original submitted 18 December 2013; Revision submitted 31 March 2014

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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