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Preliminary Communication

Accumulation of amino-polyvinyl alcohol-coated superparamagnetic iron oxide nanoparticles in bone marrow: implications for local stromal cells

    Frank Schulze

    Julius Wolff Institute, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

    Berlin-Brandenburg School for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

    ,
    Azza Gramoun

    Department of Radiology, Geneva University Hospitals & University of Geneva, 1205 Geneva, Switzerland

    Department of Oral Biology, Faculty of Oral & Dental Medicine, Cairo University, Cairo, Egypt

    ,
    Lindsey A Crowe

    Department of Radiology, Geneva University Hospitals & University of Geneva, 1205 Geneva, Switzerland

    ,
    Anke Dienelt

    Julius Wolff Institute, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

    Berlin-Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

    ,
    Tugba Akcan

    Julius Wolff Institute, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

    ,
    Heinrich Hofmann

    Laboratory of Powder Technology, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland

    ,
    Jean-Paul Vallée

    Department of Radiology, Geneva University Hospitals & University of Geneva, 1205 Geneva, Switzerland

    ,
    Georg N Duda

    *Author for correspondence:

    E-mail Address: georg.duda@charite.de

    Julius Wolff Institute, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

    Berlin-Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

    &
    Andrea Ode

    Julius Wolff Institute, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

    Berlin-Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany

    Published Online:https://doi.org/10.2217/nnm.15.62

    Aims: First, it will be investigated if amino-polyvinyl alcohol-coated superparamagnetic iron oxide nanoparticles (A-PVA-SPIONs) are suitable for MRI contrast enhancement in bone marrow. Second, the impact of A-PVA-SPION exposure in vivo on the viability and key functions of local bone marrow stromal cells (BMSCs) will be investigated. Material & methods: Animals were systemically injected with A-PVA-SPIONs, followed by a 7-day survival time. Accumulation of A-PVA-SPIONs was confirmed by MRI, histology and inductively coupled plasma optical emission spectrometry. BMSCs were isolated from bone marrow for in vitro assessment of their viability and regenerative key functions. Results: In this study, A-PVA-SPIONs were found to accumulate in bone marrow and increase the BMSCs’ metabolic activity and migration rate. Conclusion: A-PVA-SPIONs appear suitable for contrast enhancement in bone marrow while our data suggest an influence on the BMSCs biology that necessitates future research.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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