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Nanomaterial-based ophthalmic therapies

    Harald Unterweger

    Department of Otorhinolaryngology, Head & Neck Surgery, Section of Experimental Oncology & Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glueckstr. 10a, Erlangen, 91054, Germany

    ,
    Christina Janko

    Department of Otorhinolaryngology, Head & Neck Surgery, Section of Experimental Oncology & Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glueckstr. 10a, Erlangen, 91054, Germany

    ,
    Mehtap Civelek

    Department of Otorhinolaryngology, Head & Neck Surgery, Section of Experimental Oncology & Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glueckstr. 10a, Erlangen, 91054, Germany

    ,
    Iwona Cicha

    Department of Otorhinolaryngology, Head & Neck Surgery, Section of Experimental Oncology & Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glueckstr. 10a, Erlangen, 91054, Germany

    ,
    Helmut Spielvogel

    Department of Otorhinolaryngology, Head & Neck Surgery, Section of Experimental Oncology & Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glueckstr. 10a, Erlangen, 91054, Germany

    ,
    Rainer Tietze

    Department of Otorhinolaryngology, Head & Neck Surgery, Section of Experimental Oncology & Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glueckstr. 10a, Erlangen, 91054, Germany

    ,
    Bernhard Friedrich

    Department of Otorhinolaryngology, Head & Neck Surgery, Section of Experimental Oncology & Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glueckstr. 10a, Erlangen, 91054, Germany

    &
    Christoph Alexiou

    *Author for correspondence: Tel.: +49 913 1853 3142;

    E-mail Address: c.alexiou@web.de

    Department of Otorhinolaryngology, Head & Neck Surgery, Section of Experimental Oncology & Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glueckstr. 10a, Erlangen, 91054, Germany

    Published Online:https://doi.org/10.2217/nnm-2023-0109
    Free first page

    References

    • 1. Gote V, Sikder S, Sicotte J, Pal D. Ocular drug delivery: present innovations and future challenges. J. Pharmacol. Exp. Ther. 370(3), 602–624 (2019).
    • 2. Sampat KM, Garg SJ. Complications of intravitreal injections. Curr. Opin. Ophthalmol. 21(3), 178–183 (2010).
    • 3. Wong WL, Su X, Li X et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob. Health 2(2), e106–e116 (2014).
    • 4. Ferris FL 3rd, Wilkinson CP, Bird A et al. Clinical classification of age-related macular degeneration. Ophthalmology 120(4), 844–851 (2013).
    • 5. Flores R, Carneiro A, Vieira M, Tenreiro S, Seabra MC. Age-related macular degeneration: pathophysiology, management, and future perspectives. Ophthalmologica 244(6), 495–511 (2021).
    • 6. Lin TC, Hung KH, Peng CH et al. Nanotechnology-based drug delivery treatments and specific targeting therapy for age-related macular degeneration. J. Chin. Med. Assoc. 78(11), 635–641 (2015).
    • 7. Bourne RRA, Jonas JB, Bron AM et al. Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe in 2015: magnitude, temporal trends and projections. Brit. J. Ophthalmol. 102(5), 575–585 (2018).
    • 8. Boehm BO, Lang G, Feldmann B et al. Proliferative diabetic retinopathy is associated with a low level of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor. A pilot study. Horm. Metab. Res. 35(6), 382–386 (2003).
    • 9. Visvesvara GS, Moura H, Schuster FL. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. Fems. Immunol. Med. Mic. 50(1), 1–26 (2007).
    • 10. Lorenzo-Morales J, Khan NA, Walochnik J. An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment. Parasite 22, 10 (2015).
    • 11. CDC. Parasites–Acanthamoeba–granulomatous amebic encephalitis (gae); keratitis (2013). www.cdc.gov/parasites/acanthamoeba/health_professionals/index.html (Accessed 24 March 2023).
    • 12. Carnt N, Stapleton F. Strategies for the prevention of contact lens-related Acanthamoeba keratitis: a review. Ophthal. Phys. Opt. 36(2), 77–92 (2016).
    • 13. Martin-Navarro CM, Lorenzo-Morales J, Machin RP et al. Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme a reductase and application of statins as a novel effective therapeutic approach against Acanthamoeba infections. Antimicrob. Agents Chemother. 57(1), 375–381 (2013).
    • 14. Tham Y-C, Li X, Wong TY, Quigley HA, Aung T, Cheng C-Y. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 121(11), 2081–2090 (2014).
    • 15. Peng JJ, Song WT, Yao F et al. Involvement of regulated necrosis in blinding diseases: focus on necroptosis and ferroptosis. Exp. Eye Res. 191, 107922 (2020).
    • 16. Pasparakis M, Vandenabeele P. Necroptosis and its role in inflammation. Nature 517(7534), 311–320 (2015).
    • 17. Mifflin L, Ofengeim D, Yuan J. Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target. Nat. Rev. Drug Discov. 19(8), 553–571 (2020).
    • 18. Das S, Singh S, Kumar A. Bacterial burden declines but neutrophil infiltration and ocular tissue damage persist in experimental Staphylococcus epidermidis endophthalmitis. Front. Cell Infect. Microbiol. 11, 780648 (2021).
    • 19. Sahay P, Goel S, Nagpal R et al. Infectious keratitis caused by rare and emerging micro-organisms. Curr. Eye Res. 45(7), 761–773 (2020).
    • 20. Thomas RK, Melton R, Asbell PA. Antibiotic resistance among ocular pathogens: current trends from the ARMOR surveillance study (2009–2016). Clin. Optom. 11, 15–26 (2019).