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Ultrasound-based nanomedicine for molecular imaging of prostate cancer: from diagnostics to theranostics

    Yunkai Zhu

    Department of Ultrasound in Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, PR China

    ‡Authors contributed equally

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    ,
    Ying Sun

    State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, PR China

    ‡Authors contributed equally

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    ,
    Yourong Duan

    *Author for correspondence:

    E-mail Address: yrduan@shsci.org

    State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, PR China

    &
    Yaqing Chen

    **Author for correspondence:

    E-mail Address: chenyaqing@xinhuamed.com.cn

    Department of Ultrasound in Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, PR China

    Published Online:https://doi.org/10.2217/nnm-2021-0170
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    References

    • 1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA Cancer J. Clin. 71(1), 7–33 (2021).
    • 2. Sung H, Ferlay J, Siegel RL et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021).
    • 3. Andreoiu M, Cheng L. Multifocal prostate cancer: biologic, prognostic, and therapeutic implications. Hum. Pathol. 41(6), 781–793 (2010).
    • 4. Priester A, Natarajan S, Khoshnoodi P et al. Magnetic resonance imaging underestimation of prostate cancer geometry: use of patient specific molds to correlate images with whole mount pathology. J. Urol. 197(2), 320–326 (2017).
    • 5. Mottet N, van den Bergh RCN, Briers E et al. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur. Urol. 79(2), 243–262 (2021).
    • 6. Mohler JL, Antonarakis ES, Armstrong AJ et al. Prostate cancer, version 2.2019, NCCN clinical practice guidelines in oncology. J. Natl Compr. Canc. Netw. 17(5), 479–505 (2019).
    • 7. Grey A, Ahmed HU. Multiparametric ultrasound in the diagnosis of prostate cancer. Curr. Opin. Urol. 26(1), 114–119 (2016).
    • 8. Smeenge M, Tranquart F, Mannaerts CK et al. First-in-human ultrasound molecular imaging with a VEGFR2-specific ultrasound molecular contrast agent (BR55) in prostate cancer: a safety and feasibility pilot study. Invest. Radiol. 52(7), 419–427 (2017).
    • 9. Wu H, Rognin NG, Krupka TM et al. Acoustic characterization and pharmacokinetic analyses of new nanobubble ultrasound contrast agents. Ultrasound Med. Biol. 39(11), 2137–2146 (2013).
    • 10. Zlitni A, Gambhir SS. Molecular imaging agents for ultrasound. Curr. Opin. Chem. Biol. 45, 113–120 (2018).
    • 11. Wischhusen J, Padilla F. Ultrasound-targeted microbubble destruction (UTMD) for localized drug delivery into tumor tissue. IRBM 40(1), 10–15 (2019).
    • 12. Ding Y, Cao Q, Qian S et al. Optimized anti-prostate-specific membrane antigen single-chain variable fragment-loaded nanobubbles as a novel targeted ultrasound contrast agent for the diagnosis of prostate cancer. J. Ultrasound Med. 39(4), 761–773 (2020).
    • 13. Perera RH, de Leon A, Wang X et al. Real time ultrasound molecular imaging of prostate cancer with PSMA-targeted nanobubbles. Nanomedicine 28, 102213 (2020).
    • 14. Zhao M, Zhu Y, Zhang Y et al. CDCP1-targeted nanoparticles encapsulating phase-shift perfluorohexan for molecular US imaging in vitro. Clin. Hemorheol. Microcirc. doi:10.3233/CH-200900 (2020) (Epub ahead of print).
    • 15. Zhu Y, Sun Y, Liu W et al. Magnetic polymeric nanobubbles with optimized core size for MRI/ultrasound bimodal molecular imaging of prostate cancer. Nanomedicine (Lond.) 15(30), 2901–2916 (2020).
    • 16. Wang Y, Lan M, Shen D et al. Targeted nanobubbles carrying indocyanine green for ultrasound, photoacoustic and fluorescence imaging of prostate cancer. Int. J. Nanomedicine 15, 4289–4309 (2020).
    • 17. Wu M, Wang Y, Wang Y et al. Paclitaxel-loaded and A10-3.2 aptamer-targeted poly(lactide-co-glycolic acid) nanobubbles for ultrasound imaging and therapy of prostate cancer. Int. J. Nanomedicine 12, 5313–5330 (2017).
    • 18. Wu M, Zhao H, Guo L et al. Ultrasound-mediated nanobubble destruction (UMND) facilitates the delivery of A10-3.2 aptamer targeted and siRNA-loaded cationic nanobubbles for therapy of prostate cancer. Drug Deliv. 25(1), 226–240 (2018).
    • 19. You Y, Liang X, Yin T et al. Porphyrin-grafted lipid microbubbles for the enhanced efficacy of photodynamic therapy in prostate cancer through ultrasound-controlled in situ accumulation. Theranostics 8(6), 1665–1677 (2018).