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Research Article

Effects of nanoscale electric fields on the histology of liver cell dysplasia

    Aya O Balbaa

    Medical Research Institute, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    Biology Department, School of Sciences & Engineering, American University in Cairo, New Cairo 11835, Egypt

    ,
    Ahmed Abd El-Fattah

    Department of Materials Science, Institute of Graduate Studies & Research, Alexandria University, Alexandria, Egypt

    Department of Chemistry, College of Science, University of Bahrain

    ,
    Nahla M Awad

    Early Cancer Detection Unit. Ain Shams University Hospitals, Cairo, Egypt

    &
    Ahmed Abdellatif

    *Author for correspondence:

    E-mail Address: ahmed.abdellatif@aucegypt.edu

    Biology Department, School of Sciences & Engineering, American University in Cairo, New Cairo 11835, Egypt

    Published Online:https://doi.org/10.2217/nnm-2018-0260

    Cells electrical fields have a significant role in cell function. Aim: The current study examined the effects of nanoscale electric fields generated by magneto-electric nanoparticles (MENs) on precancerous liver tissue. Methods & results: A total of 30 nm MENs synthesized by sol-gel method were tested in vitro on HepG2 cells and in vivo on liver cell dysplasia in mice, which were exposed to 50 Hz 2 mT for 2 weeks, +/- MENs. MENs with alternating field (AF) reversed liver cells dysplastic features. In vitro cytotoxicity assay showed high lethal dose (LD 50) of 1.4 mg/ml. We also report on the expression of alpha-fetoprotein and cytochrome C. Conclusion: MEN-generated nanoscale electric fields have significant biological effects on precancerous liver cells.

    Papers of special note have been highlighted as: • of interest

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