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Research Article

Ventral hernia repair in rat using nanofibrous polylactic acid/polypropylene meshes

    Ye Xiaolong

    Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China

    Authors contributed equally

    Search for more papers by this author

    ,
    Han Xiaoyan

    Central Laboratory, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China

    Authors contributed equally

    Search for more papers by this author

    ,
    Wei Bo

    Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China

    ,
    Huang Jianglong

    Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China

    ,
    Yang Xiaofeng

    Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China

    ,
    Tang Xiao

    Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China

    ,
    Zheng Zongheng

    Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China

    ,
    Luo Linbo

    Medprin Regenerative Medical Technologies Co. Ltd Guangzhou, Guangdong 510630, China

    ,
    Zhan Zefeng

    Medprin Regenerative Medical Technologies Co. Ltd Guangzhou, Guangdong 510630, China

    &
    Wei Hongbo

    *Author for correspondence:

    E-mail Address: drweihb@126.com

    Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China

    Published Online:https://doi.org/10.2217/nnm-2018-0165

    Aim: In the present study, we combined a nanofibrous polylactic acid (PLA) scaffold fabricated by electrospinning with a polypropylene (PP) material to generate a new type of mesh for hernia repair. Materials & methods: The PLA/PP mesh was tested with tensile testing, in vitro cytocompatibility and degradation. A total of 90 rats were randomly allocated to PLA/PP, PP and polyester (PE) mesh groups for the in vivo study to evaluate the properties of PLA/PP mesh. Results: PLA/PP mesh had superior mechanical properties. It also resulted in less inflammation adhesion formation (p < 0.05), which was related to the TGF-β1/Smad pathway. The distribution of collagen I and III in PLA/PP mesh was also superior to those in the other two groups (p < 0.05). Conclusion: The PLA/PP mesh would be suitable for ventral hernia repair in the future.

    Papers of special note have been highlighted as: • of interests; •• of considerable interest

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