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† Author for correspondence

Email the corresponding author at frank.vari@qimr.edu.au

Clinical Immunohaematology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland, 4006, Australia

Department of Haematology, Princess Alexandra Hospital, Brisbane, Queensland, 4102, Australia

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Published Online:13 Jun 2011https://doi.org/10.2217/imt.11.56

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Abstract

Evaluation of: Lin Y, Gustafson MP, Bulur PA, Gastineau DA, Witzig TE, Dietz AB: Immunosuppressive CD14⁺HLA-DR^low/- monocytes in B-cell non-Hodgkin’s lymphoma. Blood 117, 872–881 (2011). The mechanisms of systemic immunosuppression in B-cell non-Hodgkin’s lymphoma (NHL) are poorly characterized. Lin and colleagues collected blood from 40 NHL patients prior to therapy. Monocytes from NHL patients suppressed T-cell proliferation, were unresponsive to Toll-like receptor stimulation by CpG and resistant to maturing into CD83⁺ dendritic cells. This suppression was mediated in part through arginine metabolism, as exogenous arginine supplementation reversed this, and NHL patients had elevated arginase I in their plasma. These cells had decreased HLA-DR and TNF-α receptor II (CD120b) expression compared with controls. Patients with increased ratios of CD14⁺HLA-DR^low/- monocytes had more advanced disease and suppressed immune functions, indicating that CD14⁺HLA-DR^low/- monocytes are a pivotal and profoundly effective contributor to systemic immunosuppression in NHL.

Keywords:

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Published online 13 June 2011

Published in print June 2011

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Financial & competing interests disclosure

Work in the Clinical Immunohaematology Laboratory, QIMR is supported by the NHMRC (Australia), Atlantic Philanthropies, Cancer Council Queensland, Leukaemia Foundation, Research Infrastructure Support Services Australia, Roche Organ Transplantation Foundation and the Australian Centre for Vaccine Development. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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Broad-spectrum immunosuppression by classless monocytes in non-Hodgkin’s lymphoma

Abstract

Bibliography