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The predictive effect of the systemic immune-inflammation index for patients with small-cell lung cancer

    Duoying Wang

    Department of Clinical Medicine, Weifang Medical University, Weifang, PR China

    Department of Radiotherapy, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, PR China

    ,
    Dong Guo

    Department of Radiotherapy, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, PR China

    ,
    Fang Shi

    Department of Radiotherapy, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, PR China

    ,
    Ying Zhu

    Department of Clinical Medicine, Weifang Medical University, Weifang, PR China

    ,
    Aijie Li

    Department of Clinical Medicine, Weifang Medical University, Weifang, PR China

    Department of Radiotherapy, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, PR China

    ,
    Li Kong

    Department of Radiotherapy, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, PR China

    ,
    Feifei Teng

    *Author for correspondence: Tel.: +86 531 8798 4947; Fax: +86 0531 8798 4079;

    E-mail Address: tengfeifei16@126.com

    Department of Radiotherapy, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, PR China

    &
    Jinming Yu

    **Author for correspondence: Tel.: +86 531 8798 4729; Fax: +86 0531 8798 4079;

    E-mail Address: sdyujinming@163.com

    Department of Radiotherapy, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, PR China

    Published Online:https://doi.org/10.2217/fon-2019-0288

    Aim: The purpose of this study was to investigate the predictive power of the systemic immune inflammation index (SII) based on neutrophil (N), platelet (P) and lymphocyte (L) on the clinical outcomes of patients with SCLC. Patients & methods: Blood samples of 228 patients were obtained 1 week before treatment to measure the SII (SII = P × N/L). Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan–Meier curves and Cox regression models. Results: Higher SII was associated with poorer OS (p < 0.001) and poorer PFS (p < 0.001). Multivariable analyses further revealed SII as an independent prognostic factor for OS (p < 0.001) and PFS (p < 0.001). Conclusion: Pretreatment SII was a valuable prognostic factor for PFS and OS in SCLC patients.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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