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The inter-talk between Mycobacterium tuberculosis and the epigenetic mechanisms

    Samira Tarashi

    Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran

    Mycobacteriology & Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran

    ,
    Sara Ahmadi Badi

    Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran

    Mycobacteriology & Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran

    ,
    Arfa Moshiri

    Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran

    Gastroenterology & Liver Diseases Research Center, Research Institute for Gastroenterology & Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Laboratory of Molecular Medicine, IRCCS Institute Giannina Gaslini, Genova, Italy

    ,
    Nayereh Ebrahimzadeh

    Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran

    Mycobacteriology & Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran

    ,
    Abolfazl Fateh

    Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran

    Mycobacteriology & Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran

    ,
    Farzam Vaziri

    Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran

    Mycobacteriology & Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran

    ,
    Hossein Aazami

    Endocrinology & Metabolism Research Center, Endocrinology & Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    ,
    Seyed Davar Siadat

    *Author for correspondence:

    E-mail Address: d.siadat@gmail.com

    Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran

    Mycobacteriology & Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran

    Endocrinologyand Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    &
    Andrea Fuso

    Department of Experimental Medicine, Sapienza University of Rome, Italy

    Published Online:https://doi.org/10.2217/epi-2019-0187

    Epigenetics regulate gene function without any alteration in the DNA sequence. The epigenetics represent one of the most important regulators in different cellular processes and have initially been developed in microorganisms as a protective strategy. The evaluation of the epigenetic mechanisms is also important in achieving an efficient control strategy in tuberculosis (TB). TB is one of the most significant epidemiological concerns in human history. Despite several in vivo and in vitro studies that have evaluated different epigenetic modifications in TB, many aspects of the association between epigenetics and TB are not fully understood. The current paper is aimed at reviewing our knowledge on histone modifications and DNA methylation modifications, as well as miRNAs regulation in TB.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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