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Research Article

Identification and integrated analysis of key differentially expressed circular RNAs in ER-positive subtype breast cancer

    Chenwei Yuan

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    Authors contributed equally

    Search for more papers by this author

    ,
    Liheng Zhou

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    Authors contributed equally

    Search for more papers by this author

    ,
    Lei Zhang

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    Authors contributed equally

    Search for more papers by this author

    ,
    Kai Yin

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    ,
    Jing Peng

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    ,
    Rui Sha

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    ,
    Shan Zhang

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    ,
    Yaqian Xu

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    ,
    Xiaonan Sheng

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    ,
    Yaohui Wang

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    ,
    Yanping Lin

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    ,
    Shuguang Xu

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    ,
    Wenjin Yin

    **Author for correspondence: Tel.: +86 021 6838 5565;

    E-mail Address: followroad@163.com

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    &
    Jinsong Lu

    *Author for correspondence: Tel.: +86 021 6838 5565;

    E-mail Address: lujjss@163.com

    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China

    Published Online:https://doi.org/10.2217/epi-2018-0147

    Aim: To systematically profile and characterize the circular RNA (circRNA) expression pattern in estrogen receptor (ER)-positive breast cancer (BC). Materials & methods: CircRNA expression profile was performed in ER-positive BC and adjacent nontumor tissues. The differentially expressed circRNAs (DECs) was analyzed by bioinformatics. The analysis findings were validated by quantitative real-time PCR. Results: In total, 3653 DECs were detected in our ER-positive BC compared with the control. Bioinformatics analysis showed that some pathways related to cancer, especially BC, were significantly enriched. Additionally, hsa_circ_0087378 was validated to be downregulated in ER-positive BC and the hsa_circ_0087378-miR-1260b-SFRP1 axis was proposed to be a key regulatory pathway. Conclusion: This study revealed the general expression characteristics of specific DECs in ER-positive BC and hsa_circ_0087378 might be a promising candidate target.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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