Associations between adiposity and repetitive element DNA methylation in healthy postmenopausal women

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1 de Koning AJ, Gu W, Castoe TA, Batzer MA, Pollock DD. Repetitive elements may comprise over two-thirds of the human genome. PLoS Genet. 7(12), e1002384 (2011).
  Medline CASGoogle Scholar
• 2 Miousse IR, Chalbot MCG, Lumen A et al. Response of transposable elements to environmental stressors. Mutat. Res. Rev. Mutat. Res. 765, 19–39 (2015). •• A review of the epigenetic mechanisms that regulate transposable elements, their potential role in disease etiology and their association with environmental risk factors.
  Medline CASGoogle Scholar
• 3 Kemp JR, Longworth MS. Crossing the LINE toward genomic instability: LINE-1 retrotransposition in cancer. Front. Chem. 3, 68 (2015).
  MedlineGoogle Scholar
• 4 Ade C, Roy-Engel AM, Deininger PL. Alu elements: an intrinsic source of human genome instability. Curr. Opin. Virol. 3(6), 639–645 (2013).
  Medline CASGoogle Scholar
• 5 Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell 128(4), 669–681 (2007).
  Medline CASGoogle Scholar
• 6 Rollins RA, Haghighi F, Edwards JR et al. Large-scale structure of genomic methylation patterns. Genome. Res. 16(2), 157–163 (2005). •• Maps the distribution and methylation of CpG sites in the human genome.
  MedlineGoogle Scholar
• 7 Matsuda Y, Yamashita S, Lee YC et al. Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization. Cancer Causes Control 23(6), 865–873 (2012).
  MedlineGoogle Scholar
• 8 Miousse IR, Koturbash I. The fine LINE: methylation drawing the cancer landscape. Biomed. Res. Int. 2015, 1–8 (2015). • A review of the hypothesized role of long interspersed nuclear element-1 methylation in the initiation and progression of cancer.
  Google Scholar
• 9 Zhu ZZ, Sparrow D, Hou L et al. Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study. Cancer Causes Control 22(3), 437–447 (2011).
  MedlineGoogle Scholar
• 10 Rodríguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat. Med. 17(3), 330–339 (2011).
  Medline CASGoogle Scholar
• 11 Deroo LA, Bolick SCE, Xu Z et al. Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study. Carcinogenesis 35(2), 333–338 (2014).
  Medline CASGoogle Scholar
• 12 King WD, Ashbury JE, Taylor SA et al. A cross-sectional study of global DNA methylation and risk of colorectal adenoma. BMC Cancer 14(1), 488 (2014).
  MedlineGoogle Scholar
• 13 Piyathilake CJ, Macaluso M, Alvarez RD et al. A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia. Nutrition 27(5), 513–519 (2011).
  Medline CASGoogle Scholar
• 14 Senthong A, Kitkumthorn N, Rattanatanyong P et al. Differences in LINE-1 methylation between endometriotic ovarian cyst and endometriosis-associated ovarian cancer. Int. J. Gynecol. Cancer 24(1), 36–42 (2014).
  MedlineGoogle Scholar
• 15 Cash HL, Tao L, Yuan JM et al. LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese. Int. J. Cancer 130(5), 1151–1159 (2012).
  Medline CASGoogle Scholar
• 16 Kawano H, Saeki H, Kitao H et al. Chromosomal instability associated with global DNA hypomethylation is associated with the initiation and progression of esophageal squamous cell carcinoma. Ann. Surg. Oncol. 21(4), 696–702 (2014).
  Google Scholar
• 17 Di J, Han X, Gu W et al. Association of hypomethylation of LINE-1 repetitive element in blood leukocyte DNA with an increased risk of hepatocellular carcinoma. J. Zhejiang Univ. Sci. B. 12(10), 805–811 (2011).
  Medline CASGoogle Scholar
• 18 Gao Y, Baccarelli A, Shu XO et al. Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health Study. Br. J. Cancer 106(3), 585–591 (2012).
  Medline CASGoogle Scholar
• 19 Muka T, Koromani F, Portilla E et al. The role of epigenetic modifications in cardiovascular disease: a systematic review. Int. J. Cardiol. 212, 174–183 (2016). • Systematic review that synthesizes results from recent investigations into the association between repetitive element DNA methylation and cardiovascular disease.
  MedlineGoogle Scholar
• 20 Terry MB, Delgado-Cruzata L, Vin-Raviv N, Wu HC, Santella RM. DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics 6(7), 828–837 (2011).
  Medline CASGoogle Scholar
• 21 Jones MJ, Goodman SJ, Kobor MS. DNA methylation and healthy human aging. Aging Cell 14(6), 924–932 (2015). • Paper reviewing age-related DNA methylation changes and its potential causes.
  Medline CASGoogle Scholar
• 22 Dixon JB. The effect of obesity on health outcomes. Mol. Cell Endocrinol. 316(2), 104–108 (2010).
  Medline CASGoogle Scholar
• 23 Vucenik I, Stains JP. Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann. NY Acad. Sci. 1271(1), 37–43 (2012).
  Medline CASGoogle Scholar
• 24 Renehan AG, Zwahlen M, Egger M. Adiposity and cancer risk: new mechanistic insights from epidemiology. Nat. Rev. Cancer 15(8), 484–498 (2015). •• Summary of our current understanding about the biological mechanisms that mediate the association between adiposity and cancer risk.
  Medline CASGoogle Scholar
• 25 Friedenreich CM, Woolcott CG, McTiernan A et al. Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J. Clin. Oncol. 28(9), 1458–1466 (2010).
  Medline CASGoogle Scholar
• 26 Friedenreich CM, Woolcott CG, McTiernan A et al. Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial. Int. J. Obes. 35(3), 427–435 (2011).
  CASGoogle Scholar
• 27 Friedenreich CM, Courneya KS, Neilson HK et al. Reliability and validity of the past year total physical activity questionnaire. Am. J. Epidemiol. 163(10), 959–970 (2006).
  MedlineGoogle Scholar
• 28 Csizmadi I, Kahle L, Ullman R et al. Adaptation and evaluation of the National Cancer Institute's Diet History Questionnaire and nutrient database for Canadian populations. Public Health Nutr. 10(1), 88–96 (2007).
  MedlineGoogle Scholar
• 29 Willet W, Howe G, Kushi L. Adjustment for total energy intake in epidemiologic studies. Am. J. Clin. Nutr. 65(4), 1220S–1228S (1997).
  MedlineGoogle Scholar
• 30 Chavez-MacGregor M, Elias SG, Onland-Moret NC et al. Postmenopausal breast cancer risk and cumulative number of menstrual cycles. Cancer Epidemiol. Biomarkers Prev. 14(4), 799–804 (2005).
  MedlineGoogle Scholar
• 31 Kile ML, Baccarelli A, Tarantini L, Hoffman E, Wright RO, Christiani DC. Correlation of global and gene-specific DNA methylation in maternal-infant pairs. PLoS ONE 5(10), e13730 (2010).
  MedlineGoogle Scholar
• 32 Piyathilake CJ, Badiga S, Alvarez RD, Partridge EE, Johanning GL. A lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR in the presence of lower concentrations of plasma folate. PLoS ONE 8(1), e54544 (2013).
  Medline CASGoogle Scholar
• 33 Kihara S, Matsuzawa Y. Fat distribution and cardiovascular disease risk. Curr. Cardiovasc. Risk Rep. 9(3), 4–9 (2015).
  MedlineGoogle Scholar
• 34 van Dijk SJ, Molloy PL, Varinli H, Morrison JL, Muhlhausler BS. Epigenetics and human obesity. Int. J. Obes. 39, 1–13 (2014). •• A systematic review of epidemiologic studies investigating the association between adiposity and epigenetic modifications.
  Google Scholar
• 35 Delgado-Cruzata L, Zhang W, McDonald JA et al. Dietary modifications, weight loss, and changes in metabolic markers affect global DNA methylation in hispanic, African American, and Afro-Caribbean breast cancer survivors. J. Nutr. 145(4), 783–790 (2015).
  Medline CASGoogle Scholar
• 36 Martín-Núñez GM, Cabrera-Mulero R, Rubio-Martín E et al. Methylation levels of the SCD1 gene promoter and LINE-1 repeat region are associated with weight change: an intervention study. Mol. Nutr. Food Res. 58(7), 1528–1536 (2014).
  Medline CASGoogle Scholar
• 37 Cash HL, McGarvey ST, Houseman EA et al. Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders. Epigenetics 6(10), 1257–1264 (2011).
  Medline CASGoogle Scholar
• 38 Perng W, Villamor E, Shroff MR et al. Dietary intake, plasma homocysteine, and repetitive element DNA methylation in the Multi-Ethnic Study of Atherosclerosis (MESA). Nutr. Metab. Cardiovasc. Dis. 24(6), 614–622 (2014).
  Medline CASGoogle Scholar
• 39 Zhang FF, Cardarelli R, Carroll J et al. Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics 6(5), 623–629 (2014).
  Google Scholar
• 40 Duggan C, Xiao L, Terry MB, McTiernan A. No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women. Obesity 22(9), 2091–2096 (2014).
  Medline CASGoogle Scholar
• 41 Zhu ZZ, Hou L, Bollati V et al. Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int. J. Epidemiol. 41(1), 126–39 (2012).
  MedlineGoogle Scholar
• 42 Marques-Rocha JL, Milagro FI, Mansego ML, Mourão DM, Martínez JA, Bressan J. LINE-1 methylation is positively associated with healthier lifestyle but inversely related to body fat mass in healthy young individuals. Epigenetics 11(1), 49–60 (2016).
  MedlineGoogle Scholar
• 43 Jintaridth P, Tungtrongchitr R, Preutthipan S, Mutirangura A. Hypomethylation of Alu elements in post-menopausal women with osteoporosis. PLoS ONE 8(8), 1–8 (2013).
  Google Scholar
• 44 Na YK, Hong HS, Lee DH, Lee WK, Kim DS. Effect of body mass index on global DNA methylation in healthy Korean women. Mol. Cells 37(6), 467–472 (2014).
  MedlineGoogle Scholar
• 45 Andreotti G, Karami S, Pfeiffer RM et al. LINE1 methylation levels associated with increased bladder cancer risk in pre-diagnostic blood DNA among US (PLCO) and European (ATBC) cohort study participants. Epigenetics 9(3), 404–415 (2013).
  MedlineGoogle Scholar
• 46 Liao LM, Brennan P, van Bemmel DM et al. LINE-1 methylation levels in leukocyte DNA and risk of renal cell cancer. PLoS ONE 6(11), e27361 (2011).
  Medline CASGoogle Scholar
• 47 Tajuddin SM, Amaral AFS, Fernández AF et al. LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk. Br. J. Cancer 110(8), 2123–2130 (2014).
  Medline CASGoogle Scholar
• 48 Dixon JB, O'Brien PE. Obesity and the white blood cell count: changes with sustained weight loss. Obes. Surg. 16(3), 251–257 (2006).
  MedlineGoogle Scholar
• 49 Lowe R, Slodkowicz G, Goldman N, Rakyan VK. The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues. Epigenetics 10(4), 274–281 (2015).
  MedlineGoogle Scholar
• 50 Chalitchagorn K, Shuangshoti S, Hourpai N et al. Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis. Oncogene 23(54), 8841–8846 (2004).
  Medline CASGoogle Scholar
• 51 Ashbury JE, Taylor SA, Tse MY et al. Biomarkers measured in buccal and blood leukocyte DNA as proxies for colon tissue global methylation. Int. J. Mol. Epidemiol. Genet. 5(2), 120–124 (2014).
  MedlineGoogle Scholar
• 52 Rothman KJ. BMI-related errors in the measurement of obesity. Int. J. Obes. 32, S56–S59 (2008).
  Google Scholar
• 53 Sun G, French CR, Martin GR et al. Comparison of multifrequency bioelectrical impedance analysis with dual-energy x-ray absorptiometry for assessment of percentage body fat in a large, healthy population. Am. J. Clin. Nutr. 81(1), 74–78 (2005).
  Medline CASGoogle Scholar