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Regenerative Medicine

Low expression of GOT2 promotes tumor progress and predicts poor prognosis in hepatocellular carcinoma

    Qiuli Liang

    School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China

    Nanning Center for Disease Control & Prevention, Nanning, Guangxi, 530002, China

    ,
    Shun Liu

    School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China

    ,
    Fuqiang Yin

    Life Sciences Institute Guangxi Medical University, Nanning, Guangxi, 530021, China

    Key Laboratory of High-Incidence-Tumor Prevention & Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, 530021, China

    ,
    Meiliang Liu

    School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China

    ,
    Lijun Wang

    School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China

    ,
    Erna Guo

    School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China

    School of International Education, Guangxi Medical University, Nanning, Guangxi, 530021, China

    ,
    Lei Lei

    School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China

    ,
    Liuyu Wu

    Department of Hospital Infection Control, Liuzhou People’s Hospital, Liuzhou, Guangxi, 545026, China

    ,
    Yu Yang

    School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China

    ,
    Di Zhang

    Department of Scientific Research, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China

    &
    Xiaoyun Zeng

    *Author for correspondence:

    E-mail Address: zengxiaoyun@gxmu.edu.cn

    School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China

    Key Laboratory of High-Incidence-Tumor Prevention & Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, 530021, China

    Published Online:https://doi.org/10.2217/bmm-2023-0236

    Background: To explore the biological function and the underlying mechanisms of GOT2 in hepatocellular carcinoma (HCC). Materials & methods: The expression level and prognostic value of GOT2 were examined using International Cancer Genome Consortium and International Cancer Proteogenome Consortium databases. The cell counting kit-8 method, clone formation, Transwell® assays and western blotting were used to evaluate the effects of GOT2 on the biological function and autophagy of HCC cells. Results: The expression of GOT2 was downregulated in HCC tissues and correlated with poor prognosis of HCC patients. Knockdown of GOT2 promoted proliferation, migration and invasion of HCC cells and promoted cells’ proliferation by inducing autophagy. Conclusion:GOT2 plays a tumor-inhibitory role in HCC and may be a potential therapeutic target for HCC.

    Tweetable abstract

    GOT2 is a biomarker that inhibited proliferation, migration and invasion of hepatocellular carcinoma and affected cell proliferation through autophagy.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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