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Association between high Gal-3 serum levels and worsening of renal function in chronic heart failure outpatients

    Massimo Iacoviello

    *Author for correspondence: Tel.: +39 080 547 8622; Fax: +39 080 547 8796;

    E-mail Address: massimo.iacoviello@policlinico.ba.it

    University Cardiology Unit, Cardiothoracic Department, Policlinic University Hospital, 70124, Bari, Italy

    ,
    Francesca Di Serio

    Clinic Pathology Unit, Policlinic University Hospital, 70124, Bari, Italy

    ,
    Caterina Rizzo

    Division of Cardiology and Cardiac Rehabilitation, Scientific Clinical Institutes Maugeri, IRCCS, Institute of Cassano delle Murge, 70020, Cassano delle Murge, Bari, Italy

    ,
    Marta Leone

    Cardiology Unit, Santissima Annunziata Hospital, 74100, Taranto, Italy

    ,
    Dario Grande

    Cardiology Department, Bari Local Health Service, 70123, Bari, Italy

    ,
    Pietro Guida

    Division of Cardiology and Cardiac Rehabilitation, Scientific Clinical Institutes Maugeri, IRCCS, Institute of Cassano delle Murge, 70020, Cassano delle Murge, Bari, Italy

    ,
    Margherita Ilaria Gioia

    Cardiology Department, Bari Local Health Service, 70123, Bari, Italy

    ,
    Giuseppe Parisi

    Cardiology Department, Bari Local Health Service, 70123, Bari, Italy

    ,
    Tiziana Leopizzi

    Cardiology Department, Bari Local Health Service, 70123, Bari, Italy

    ,
    Pasquale Caldarola

    School of Cardiology, University of Bari, 70124, Bari, Italy

    ,
    Marco Matteo Ciccone

    Cardiology Department, Bari Local Health Service, 70123, Bari, Italy

    &
    Loreto Gesualdo

    University Nephrology Unit, D.E.T.O., University of Bari, 70124, Bari, Italy

    Published Online:https://doi.org/10.2217/bmm-2018-0349

    Aim: The aim of the study was to evaluate the association between Gal-3 serum levels and the progression of renal dysfunction in chronic heart failure outpatients. Methods & results: This prospective study of 260 chronic heart failure patients showed that Gal-3 was associated with 1-year worsening of renal function both in univariate (odds ratio: 1.12; 95% CI: 1.06–1.18; p < 0.001) and in forward stepwise multivariate (odds ratio: 1.09; 95% CI: 1.03–1.15; p = 0.004) logistic regression analyses. Moreover, high Gal-3 levels at baseline were associated with a progressive decline in the estimated glomerular filtration rate. Conclusion: Gal-3 is a biomarker associated with the progression of renal function decline thus further supporting its possible usefulness in predicting cardiorenal syndrome progression.

    Papers of special note have been highlighted as: • of interest

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