Implications of multipotent mesenchymal stromal cell aging

References

• 1  Sharpless NE, Depinho RA. How stem cells age and why this makes us grow old. Nat. Rev. Mol. Cell Biol.8(9),703–713 (2007).
  Medline CASGoogle Scholar
• 2  Conboy IM, Rando TA. Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches. Cell Cycle11(12),2260–2267 (2012).
  Medline CASGoogle Scholar
• 3  Nagaria P, Robert C, Rassool FV. DNA double-strand break response in stem cells: mechanisms to maintain genomic integrity. Biochim. Biophys. Acta1830(2),2345–2353 (2012).
  MedlineGoogle Scholar
• 4  Beausejour CM, Campisi J. Ageing: balancing regeneration and cancer. Nature443(7110),404–405 (2006).
  Medline CASGoogle Scholar
• 5  Rodier F, Campisi J. Four faces of cellular senescence. J. Cell Biol.192(4),547–556 (2011).
  Medline CASGoogle Scholar
• 6  Kuilman T, Michaloglou C, Mooi WJ, Peeper DS. The essence of senescence. Genes Dev.24(22),2463–2479 (2010).
  Medline CASGoogle Scholar
• 7  Liu Y, Johnson SM, Fedoriw Y et al. Expression of p16(ink4a) prevents cancer and promotes aging in lymphocytes. Blood117(12),3257–3267 (2011).
  Medline CASGoogle Scholar
• 8  Dominici M, le Blanc K, Mueller I et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy8(4),315–317 (2006).
  Medline CASGoogle Scholar
• 9  Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp. Hematol.4(5),267–274 (1976).
  Medline CASGoogle Scholar
• 10  Keating A. Mesenchymal stromal cells: new directions. Cell Stem Cell10(6),709–716 (2012).
  Medline CASGoogle Scholar
• 11  Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science284(5411),143–147 (1999).
  Medline CASGoogle Scholar
• 12  Macdonald GI, Augello A, de Bari C. Role of mesenchymal stem cells in reestablishing immunologic tolerance in autoimmune rheumatic diseases. Arthritis Rheum.63(9),2547–2557 (2011).
  Medline CASGoogle Scholar
• 13  Singer NG, Caplan AI. Mesenchymal stem cells: mechanisms of inflammation. Annu. Rev. Pathol.6,457–478 (2011).
  Medline CASGoogle Scholar
• 14  le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat. Rev. Immunol.12(5),383–396 (2012).
  Medline CASGoogle Scholar
• 15  Campisi J. Aging, cellular senescence, and cancer. Annu. Rev. Physiol. doi:10.1146/annurev-physiol-030212-183653 (2012) (Epub ahead of print).
  MedlineGoogle Scholar
• 16  Lepperdinger G. Inflammation and mesenchymal stem cell aging. Curr. Opin. Immunol.23(4),518–524 (2011).
  Medline CASGoogle Scholar
• 17  Voog J, Jones DL. Stem cells and the niche: a dynamic duo. Cell Stem Cell6(2),103–115 (2010).
  Medline CASGoogle Scholar
• 18  Fossett E, Khan WS, Pastides P, Adesida AB. The effects of ageing on proliferation potential, differentiation potential and cell surface characterisation of human mesenchymal stem cells. Curr. Stem Cell Res. Ther.7(4),282–286 (2012).
  Medline CASGoogle Scholar
• 19  Cmielova J, Havelek R, Soukup T et al. Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments. Int. J. Radiat. Biol.88(5),393–404 (2012).
  Medline CASGoogle Scholar
• 20  Schellenberg A, Stiehl T, Horn P et al. Population dynamics of mesenchymal stromal cells during culture expansion. Cytotherapy14(4),401–411 (2012).
  Medline CASGoogle Scholar
• 21  Wagner W, Bork S, Lepperdinger G et al. How to track cellular aging of mesenchymal stromal cells? Aging (Albany NY)2(4),224–230 (2010).
  Medline CASGoogle Scholar
• 22  Stolzing A, Jones E, McGonagle D, Scutt A. Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech. Ageing Dev.129(3),163–173 (2008).
  Medline CASGoogle Scholar
• 23  Shen J, Tsai YT, Dimarco NM, Long MA, Sun X, Tang L. Transplantation of mesenchymal stem cells from young donors delays aging in mice. Sci. Rep.1,67 (2011).
  Medline CASGoogle Scholar
• 24  Wagner W, Horn P, Castoldi M et al. Replicative senescence of mesenchymal stem cells: a continuous and organized process. PLoS One3(5),e2213 (2008).
  MedlineGoogle Scholar
• 25  Bork S, Pfister S, Witt H et al. DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell9(1),54–63 (2010).
  Medline CASGoogle Scholar
• 26  Zhou S, Greenberger JS, Epperly MW et al. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell7(3),335–343 (2008).
  Medline CASGoogle Scholar
• 27  Brohlin M, Kingham PJ, Novikova LN, Novikov LN, Wiberg M. Aging effect on neurotrophic activity of human mesenchymal stem cells. PLoS One7(9),e45052 (2012).
  Medline CASGoogle Scholar
• 28  Cheleuitte D, Mizuno S, Glowacki J. In vitro secretion of cytokines by human bone marrow: effects of age and estrogen status. J. Clin. Endocrinol. Metab.83(6),2043–2051 (1998).
  Medline CASGoogle Scholar
• 29  Makhluf HA, Mueller SM, Mizuno S, Glowacki J. Age-related decline in osteoprotegerin expression by human bone marrow cells cultured in three-dimensional collagen sponges. Biochem. Biophys. Res. Commun.268(3),669–672 (2000).
  Medline CASGoogle Scholar
• 30  Geng S, Zhou S, Glowacki J. Age-related decline in osteoblastogenesis and 1alpha-hydroxylase/cyp27b1 in human mesenchymal stem cells: stimulation by parathyroid hormone. Aging Cell10(6),962–971 (2011).
  Medline CASGoogle Scholar
• 31  Laschober GT, Brunauer R, Jamnig A et al. Age-specific changes of mesenchymal stem cells are paralleled by upregulation of CD106 expression as a response to an inflammatory environment. Rejuvenation Res.14(2),119–131 (2011).
  Medline CASGoogle Scholar
• 32  Koch CM, Joussen S, Schellenberg A, Lin Q, Zenke M, Wagner W. Monitoring of cellular senescence by DNA-methylation at specific CpG sites. Aging Cell11(2),366–369 (2012).
  Medline CASGoogle Scholar
• 33  Dimmeler S, Leri A. Aging and disease as modifiers of efficacy of cell therapy. Circ. Res.102(11),1319–1330 (2008).
  Medline CASGoogle Scholar
• 34  Oberdoerffer P, Sinclair DA. The role of nuclear architecture in genomic instability and ageing. Nat. Rev. Mol. Cell Biol.8(9),692–702 (2007).
  Medline CASGoogle Scholar
• 35  Finley LW, Haigis MC. The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res. Rev.8(3),173–188 (2009).
  Medline CASGoogle Scholar
• 36  Jones DL, Rando TA. Emerging models and paradigms for stem cell ageing. Nat. Cell Biol.13(5),506–512 (2011).
  Medline CASGoogle Scholar
• 37  Dreesen O, Stewart CL. Accelerated aging syndromes, are they relevant to normal human aging? Aging (Albany NY)3(9),889–895 (2011).
  Medline CASGoogle Scholar
• 38  Scaffidi P, Misteli T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat. Cell Biol.10(4),452–459 (2008).
  Medline CASGoogle Scholar
• 39  Minamino T, Komuro I. Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes. Nat. Clin. Pract. Cardiovasc. Med.5(10),637–648 (2008).
  Medline CASGoogle Scholar
• 40  Burtner CR, Kennedy BK. Progeria syndromes and ageing: what is the connection? Nat. Rev. Mol. Cell Biol.11(8),567–578 (2010).
  Medline CASGoogle Scholar
• 41  Butin-Israeli V, Adam SA, Goldman AE, Goldman RD. Nuclear lamin functions and disease. Trends Genet.28(9),464–471 (2011).
  Google Scholar
• 42  Musich PR, Zou Y. Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A. Aging (Albany NY)1(1),28–37 (2009).
  Medline CASGoogle Scholar
• 43  Smith JA, Ndoye AM, Geary K, Lisanti MP, Igoucheva O, Daniel R. A role for the werner syndrome protein in epigenetic inactivation of the pluripotency factor oct4. Aging Cell9(4),580–591 (2010).
  Medline CASGoogle Scholar
• 44  Coppede F. Premature aging syndrome. Adv. Exp. Med. Biol.724,317–331 (2012).
  Medline CASGoogle Scholar
• 45  Shin DM, Kucia M, Ratajczak MZ. Nuclear and chromatin reorganization during cell senescence and aging - a mini-review. Gerontology57(1),76–84 (2011).
  MedlineGoogle Scholar
• 46  Benson EK, Lee SW, Aaronson SA. Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence. J. Cell Sci.123(Pt 15),2605–2612 (2010).
  Medline CASGoogle Scholar
• 47  Muftuoglu M, Oshima J, Von Kobbe C, Cheng WH, Leistritz DF, Bohr VA. The clinical characteristics of werner syndrome: molecular and biochemical diagnosis. Hum. Genet.124(4),369–377 (2008).
  Medline CASGoogle Scholar
• 48  Worman HJ. Nuclear lamins and laminopathies. J. Pathol.226(2),316–325 (2012).
  Medline CASGoogle Scholar
• 49  Bohr VA. Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Trends Biochem. Sci.33(12),609–620 (2008).
  Medline CASGoogle Scholar
• 50  Bhatti S, Kozlov S, Farooqi AA, Naqi A, Lavin M, Khanna KK. ATM protein kinase: the linchpin of cellular defenses to stress. Cell. Mol. Life Sci.68(18),2977–3006 (2011).
  Medline CASGoogle Scholar
• 51  Mason PJ, Bessler M. The genetics of dyskeratosis congenita. Cancer Genet.204(12),635–645 (2011).
  Medline CASGoogle Scholar
• 52  Batista LF, Pech MF, Zhong FL et al. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature474(7351),399–402 (2011).
  Medline CASGoogle Scholar
• 53  Liu GH, Barkho BZ, Ruiz S et al. Recapitulation of premature ageing with IPSCs from Hutchinson–Gilford progeria syndrome. Nature472(7342),221–225 (2011).
  Medline CASGoogle Scholar
• 54  Alves H, van Ginkel J, Groen N et al. A mesenchymal stromal cell gene signature for donor age. PLoS One7(8),e42908 (2012).
  Medline CASGoogle Scholar
• 55  Zhang J, Lian Q, Zhu G et al. A human IPSC model of Hutchinson Gilford progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell8(1),31–45 (2011).
  Medline CASGoogle Scholar
• 56  Niedernhofer LJ, Glorioso JC, Robbins PD. Dedifferentiation rescues senescence of progeria cells but only while pluripotent. Stem Cell Res. Ther.2(3),28 (2011).
  MedlineGoogle Scholar
• 57  Andres V, Gonzalez JM. Role of A-type lamins in signaling, transcription, and chromatin organization. J. Cell Biol.187(7),945–957 (2009).
  Medline CASGoogle Scholar
• 58  Burke B, Stewart CL. The laminopathies: the functional architecture of the nucleus and its contribution to disease. Annu. Rev. Genomics Hum. Genet.7,369–405 (2006).
  Medline CASGoogle Scholar
• 59  Bar DZ, Gruenbaum Y. Reversal of age-dependent nuclear morphology by inhibition of prenylation does not affect lifespan in Caenorhabditis elegans. Nucleus1(6),499–505 (2010).
  MedlineGoogle Scholar
• 60  Zhang H, Kieckhaefer JE, Cao K. Mouse models of laminopathies. Aging Cell12(1),2–10 (2012).
  MedlineGoogle Scholar
• 61  Dahl KN, Scaffidi P, Islam MF, Yodh AG, Wilson KL, Misteli T. Distinct structural and mechanical properties of the nuclear lamina in Hutchinson–Gilford progeria syndrome. Proc. Natl Acad. Sci. USA103(27),10271–10276 (2006).
  Medline CASGoogle Scholar
• 62  Chen CY, Chi YH, Mutalif RA et al. Accumulation of the inner nuclear envelope protein sun1 is pathogenic in progeric and dystrophic laminopathies. Cell149(3),565–577 (2012).
  Medline CASGoogle Scholar
• 63  Haque F, Mazzeo D, Patel JT et al. Mammalian sun protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J. Biol. Chem.285(5),3487–3498 (2010).
  Medline CASGoogle Scholar
• 64  Kelley JB, Datta S, Snow CJ et al. The defective nuclear lamina in Hutchinson–Gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9. Mol. Cell. Biol.31(16),3378–3395 (2011).
  Medline CASGoogle Scholar
• 65  Busch A, Kiel T, Heupel WM, Wehnert M, Hubner S. Nuclear protein import is reduced in cells expressing nuclear envelopathy-causing lamin A mutants. Exp. Cell Res.315(14),2373–2385 (2009).
  Medline CASGoogle Scholar
• 66  Pujol G, Soderqvist H, Radu A. Age-associated reduction of nuclear protein import in human fibroblasts. Biochem. Biophys. Res. Commun.294(2),354–358 (2002).
  Medline CASGoogle Scholar
• 67  Allsopp RC, Vaziri H, Patterson C et al. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl Acad. Sci. USA89(21),10114–10118 (1992).
  Medline CASGoogle Scholar
• 68  Scaffidi P, Misteli T. Lamin A-dependent nuclear defects in human aging. Science312(5776),1059–1063 (2006).
  Medline CASGoogle Scholar
• 69  Scaffidi P, Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson–Gilford progeria syndrome. Nat. Med.11(4),440–445 (2005).
  Medline CASGoogle Scholar
• 70  Pegoraro G, Kubben N, Wickert U, Gohler H, Hoffmann K, Misteli T. Ageing-related chromatin defects through loss of the nurd complex. Nat. Cell Biol.11(10),1261–1267 (2009).
  Medline CASGoogle Scholar
• 71  Alt EU, Senst C, Murthy SN et al. Aging alters tissue resident mesenchymal stem cell properties. Stem Cell Res.8(2),215–225 (2012).
  Medline CASGoogle Scholar
• 72  Urs S, Turner B, Tang Y, Rostama B, Small D, Liaw L. Effect of soluble jagged1-mediated inhibition of notch signaling on proliferation and differentiation of an adipocyte progenitor cell model. Adipocyte1(1),46–57 (2012).
  Medline CASGoogle Scholar
• 73  Huang Y, Yang X, Wu Y et al. Gamma-secretase inhibitor induces adipogenesis of adipose-derived stem cells by regulation of notch and PPAR-gamma. Cell Prolif.43(2),147–156 (2010).
  Medline CASGoogle Scholar
• 74  Wenzel V, Roed D, Gabriel D. Naive adult stem cells from patients with Hutchinson–Gilford progeria syndrome express low levels of progerin in vivo. Biology Open1(6),516–526 (2012).
  Medline CASGoogle Scholar
• 75  Olive M, Harten I, Mitchell R et al. Cardiovascular pathology in Hutchinson-Gilford progeria. correlation with the vascular pathology of aging. Arterioscler. Thromb. Vasc. Biol.30(11),2301–2309 (2010).
  Medline CASGoogle Scholar
• 76  Ragnauth CD, Warren DT, Liu Y et al. Prelamin a acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging. Circulation121(20),2200–2210 (2010).
  Medline CASGoogle Scholar
• 77  McClintock D, Ratner D, Lokuge M et al. The mutant form of lamin a that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin. PLoS One2(12),e1269 (2007).
  MedlineGoogle Scholar
• 78  Bokenkamp R, Raz V, Venema A et al. differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates. PLoS One6(9),e23975 (2011).
  MedlineGoogle Scholar
• 79  Schuringa JJ, Vellenga E. Role of the polycomb group gene bmi1 in normal and leukemic hematopoietic stem and progenitor cells. Curr. Opin. Hematol.17(4),294–299 (2010).
  Medline CASGoogle Scholar
• 80  Schellenberg A, Lin Q, Schuler H et al. Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks. Aging (Albany NY)3(9),873–888 (2011).
  Medline CASGoogle Scholar
• 81  Pollina EA, Brunet A. Epigenetic regulation of aging stem cells. Oncogene30(28),3105–3126 (2011).
  Medline CASGoogle Scholar
• 82  Klotz B, Mentrup B, Regensburger M et al. 1,25-dihydroxyvitamin d3 treatment delays cellular aging in human mesenchymal stem cells while maintaining their multipotent capacity. PLoS One7(1),e29959 (2012).
  Medline CASGoogle Scholar
• 83  Breu A, Sprinzing B, Merkl K et al. Estrogen reduces cellular aging in human mesenchymal stem cells and chondrocytes. J. Orthop. Res.29(10),1563–1571 (2011).
  Medline CASGoogle Scholar
• 84  Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature433(7027),760–764 (2005).
  Medline CASGoogle Scholar
• 85  Edelberg JM, Tang L, Hattori K, Lyden D, Rafii S. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ. Res.90(10),e89–e93 (2002).
  Medline CASGoogle Scholar
• 86  Rigbolt KT, Prokhorova TA, Akimov V et al. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal.4(164),rs3 (2011).
  MedlineGoogle Scholar
• 87  Verstraeten VL, Peckham LA, Olive M et al. Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect. Proc. Natl Acad. Sci. USA108(12),4997–5002 (2011).
  Medline CASGoogle Scholar
• 88  Cao K, Graziotto JJ, Blair CD et al. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson–Gilford progeria syndrome cells. Sci. Transl. Med.3(89),89ra58 (2011).
  Medline CASGoogle Scholar