Editorial

*Author for correspondence: Tel.: +1 507 284 5514;

Marriott Heart Disease Research Program, Department of Cardiovascular Medicine, Department of Molecular Pharmacology & Experimental Therapeutics, Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA

Search for more papers by this author

Published Online:14 Nov 2023https://doi.org/10.2217/rme-2023-0200

View article

Keywords:

References

1. Future Science Group. Regenerative Medicine Journal. The Glossary for Advanced Therapies. Regen. Med. 18(12), 1–172 (2023).
MedlineGoogle Scholar
2. Terzic A. Regenerative medicine lexicon. Regen. Med. 15(12), 2325–2328 (2020).
CASGoogle Scholar
3. Yamada S, Behfar A, Terzic A. Regenerative medicine clinical readiness. Regen. Med. 16(3), 309–322 (2021).
CASGoogle Scholar
4. Califf RM, Marks PW. Biological therapies need definitive randomized controlled clinical trials. Sci. Transl. Med. 15(680), eadg2970 (2023).
MedlineGoogle Scholar
5. Terzic A, Pfenning MA, Gores GJ, Harper CM Jr. Regenerative medicine build-out. Stem Cells Transl. Med. 4(12), 1373–1379 (2015).
MedlineGoogle Scholar
6. Terzic A, Harper CM Jr, Gores GJ, Pfenning MA. Regenerative medicine blueprint. Stem Cells Dev. 22(Suppl. 1), 20–24 (2013).
MedlineGoogle Scholar
7. Terzic A, Nelson TJ. Regenerative medicine primer. Mayo Clin. Proc. 88(7), 766–775 (2013).
MedlineGoogle Scholar
8. Nelson TJ, Behfar A, Terzic A. Strategies for therapeutic repair: the “R³” regenerative medicine paradigm. Clin. Transl. Sci. 1, 168–171 (2008).
MedlineGoogle Scholar
9. Behfar A, Terzic A. Regeneration for all: An Odyssey in biotherapy. Eur. Heart J. 40(13), 1033–1035 (2019).
MedlineGoogle Scholar
10. Wyles SP, Terzic A. Building the regenerative medicine workforce of the future: an educational imperative. Regen. Med. 14(7), 613–615 (2019).
CASGoogle Scholar
11. Wyles SP, Hayden RE, Meyer FB, Terzic A. Regenerative medicine curriculum for next-generation physicians. NPJ Regen. Med. 4, 3 (2019).
MedlineGoogle Scholar
12. Hargraves IG, Behfar A, Foxen JL, Montori VM, Terzic A. Towards regeneration: the evolution of medicine from fighting to building. BMJ 361, k1586 (2018).
Google Scholar
13. Plackett B. Cells or drugs? The race to regenerate the heart. Nature 594, S16–S17 (2021).
CASGoogle Scholar
14. Zhang K, Cheng K. Stem cell-derived exosome versus stem cell therapy. Nat. Rev. Bioeng. doi: 10.1038/s44222-023-00064-2 (2023) (Epub ahead of print).
Google Scholar
15. McKinley KL, Longaker MT, Naik S. Emerging frontiers in regenerative medicine. Science 380(6647), 796–798 (2023).
Medline CASGoogle Scholar
16. Kimbrel EA, Lanza R. Next-generation stem cells – ushering in a new era of cell-based therapies. Nat. Rev. Drug Discov. 19, 463–479 (2020).
Medline CASGoogle Scholar
17. Terzic A, Waldman SA. Chronic diseases: the emerging pandemic. Clin. Transl. Sci. 4(3), 225–226 (2011).
MedlineGoogle Scholar
18. Garmany A, Yamada S, Terzic A. Longevity leap: mind the healthspan gap. NPJ Regen. Med. 6(1), 57 (2021).
Medline CASGoogle Scholar
19. Wells JM, Watt FM. Diverse mechanisms for endogenous regeneration and repair in mammalian organs. Nature 557(7705), 322–328 (2018).
Medline CASGoogle Scholar
20. Selvam A, Aggarwal T, Mukherjee M, Verma YK. Humans and robots: friends of the future? A bird's eye view of biomanufacturing industry 5.0. Biotechnol. Adv. 68, 108237 (2023).
MedlineGoogle Scholar
21. Magalhaes RS, Williams JK, Yoo KW, Yoo JJ, Atala A. A tissue-engineered uterus supports live births in rabbits. Nat. Biotechnol. 38(11), 1280–1287 (2020).
Medline CASGoogle Scholar
22. Fioretta ES, Motta SE, Lintas V et al. Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity. Nat. Rev. Cardiol. 18(2), 92–116 (2021).
MedlineGoogle Scholar
23. Pașca SP, Arlotta P, Bateup HS et al. A nomenclature consensus for nervous system organoids and assembloids. Nature 609(7929), 907–910 (2022).
Medline CASGoogle Scholar
24. Yamada S, Bartunek J, Behfar A, Terzic A. Mass customized outlook for regenerative heart failure care. Int. J. Mol. Sci. 22(21), 11394 (2021).
Medline CASGoogle Scholar
25. Yamada S, Jeon R, Garmany A, Behfar A, Terzic A. Screening for regenerative therapy responders in heart failure. Biomark. Med. 15(10), 775–783 (2021).
CASGoogle Scholar
26. Marks PW, Hahn S. Identifying the risks of unproven regenerative medicine therapies. JAMA 324(3), 241–242 (2020).
MedlineGoogle Scholar
27. Cossu G, Fears R, Griffin G, Ter Meulen V. Regenerative medicine: challenges and opportunities. Lancet 395(10239), 1746–1747 (2020).
MedlineGoogle Scholar
28. Leask F, Terzic A. Regenerative outlook: offering global solutions for equitable care. Regen. Med. 15(11), 2249–2252 (2020).
CASGoogle Scholar
29. Webster A, Terzic A. Regenerative readiness: innovation meets sociology. Regen. Med. 16(3), 189–195 (2021).
CASGoogle Scholar
30. Yamanaka S. Ekiden to iPS cells. Nat. Med. 15(10), 1145–1148 (2009).
Medline CASGoogle Scholar

Vol. 18, No. 12

Metrics

Downloaded 25 times

History

Received 13 October 2023

Accepted 16 October 2023

Published online 14 November 2023

Published in print December 2023

Information

Keywords

Acknowledgments

The author recognizes the Marriott Family Foundation for invaluable support in advancing the principles and practices of regenerative medicine. A Terzic is a Mayo Clinic Distinguished Investigator.

Financial disclosure

A Terzic acknowledges the National Institutes of Health grant award (R01 HL134664). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Competing interest disclosure

A Terzic is a co-inventor on regenerative sciences related intellectual property disclosed to Mayo Clinic. Mayo Clinic and A Terzic have interests in Rion LLC. The authors have no other competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript apart from those disclosed.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

PDF download

Modern regenerative medicine dictionary: an augmented guide to biotherapy

References