We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Medicine AI
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine

Peripheral nerve regeneration: a challenge far from being overcome

    Rui Alvites

    *Author for correspondence:

    E-mail Address: ruialvites@hotmail.com

    Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, Portugal

    Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, Portugal

    Associate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, Portugal

    Instituto Universitário de Ciências da Saúde (CESPU), Avenida Central de Gandra 1317, Gandra, 4585–116 Paredes, Portugal

    ,
    Bruna Lopes

    Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, Portugal

    Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, Portugal

    Associate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, Portugal

    ,
    André Coelho

    Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, Portugal

    Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, Portugal

    Associate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, Portugal

    &
    Ana Colette Maurício

    Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051–401 Porto, Portugal

    Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050–313 Porto, Portugal

    Associate Laboratory for Animal & Veterinary Science (AL4AnimalS), 1300–477 Lisboa, Portugal

    Published Online:https://doi.org/10.2217/rme-2023-0072
    Free first page

    References

    • 1. Hussain G, Wang J, Rasul A, Anwar H, Qasim M, Zafar S et al. Current status of therapeutic approaches against peripheral nerve injuries: a detailed story from injury to recovery. Int. J. Bio. Sci. 16(1), 116 (2020).
    • 2. Bergmeister KD, Große-Hartlage L, Daeschler SC, Rhodius P, Böcker A, Beyersdorff M et al. Acute and long-term costs of 268 peripheral nerve injuries in the upper extremity. PLOS ONE 15(4), e0229530 (2020).
    • 3. Bage T, Power DM. Iatrogenic peripheral nerve injury: a guide to management for the orthopaedic limb surgeon. EFORT Open Rev. 6(8), 607 (2021).
    • 4. Nagappan PG, Chen H, Wang D-Y. Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury. Military Medical Res. 7(1), 1–16 (2020).
    • 5. Battiston B, Papalia I, Tos P, Geuna S. Peripheral nerve repair and regeneration research: a historical note. Int. Rev. Neurobiol. 87, 1–7 (2009).
    • 6. Supra R, Agrawal DK. Peripheral Nerve Regeneration: Opportunities and Challenges. J. Spine Res. Surg. 5(1), 10 (2023).
    • 7. Ronchi G, Fregnan F, Muratori L, Gambarotta G, Raimondo S. Morphological Methods to Evaluate Peripheral Nerve Fiber Regeneration: A Comprehensive Review. Int. J. Mol. Sci. 24(3), 1818 (2023).
    • 8. Modrak M, Talukder MH, Gurgenashvili K, Noble M, Elfar JC. Peripheral nerve injury and myelination: potential therapeutic strategies. J. Neurosci. Res. 98(5), 780–795 (2020).
    • 9. Bhandari P. Management of peripheral nerve injury. J. Orthopaedics and Trauma. 10(5), 862–866 (2019).
    • 10. Gordon T. Peripheral nerve regeneration and muscle reinnervation. Int. J. Mol. Sci. 21(22), 8652 (2020).
    • 11. Kaneko A, Naito K, Nakamura S, Miyahara K, Goto K, Obata H et al. Influence of aging on the peripheral nerve repair process using an artificial nerve conduit. Exp. Therapeutic Med. 21(2), 1 (2021).
    • 12. Bosch-Queralt M, Fledrich R, Stassart RM. Schwann cell functions in peripheral nerve development and repair. Neurobiol. Dis. 176, 105952 (2023).
    • 13. Navarro X, Vivó M, Valero-Cabré A. Neural plasticity after peripheral nerve injury and regeneration. Prog. Neurobiol. 82(4), 163–201 (2007).
    • 14. Alvarez FJ, Rotterman TM, Akhter ET, Lane AR, English AW, Cope TC. Synaptic plasticity on motoneurons after axotomy: a necessary change in paradigm. Front. Mol. Neurosci. 13, 68 (2020).
    • 15. Vijayavenkataraman S. Nerve guide conduits for peripheral nerve injury repair: a review on design, materials and fabrication methods. Acta biomaterialia. 106, 54–69 (2020).
    • 16. Taylor CS, Haycock JW. Biomaterials and scaffolds for repair of the peripheral nervous system. Peripheral Nerve Tissue Engineering and Regeneration Springer, 245–79 (2022).
    • 17. Behtaj S, Ekberg JA, St John JA. Advances in electrospun nerve guidance conduits for engineering neural regeneration. Pharmaceutics 14(2), 219 (2022).
    • 18. Sasaki R, Watanabe Y, Yamato M, Okamoto T. Tissue-engineered nerve guides with mesenchymal stem cells in the facial nerve regeneration. Neurochem. Int. 148, 105062 (2021).
    • 19. Kaplan HM, Mishra P, Kohn J. The overwhelming use of rat models in nerve regeneration research may compromise designs of nerve guidance conduits for humans. J. Mat. Sci.: Mat. Med. 26, 1–5 (2015).
    • 20. Li A, Pereira C, Hill EE, Vukcevich O, Wang A. In vitro in vivo and ex vivo models for peripheral nerve injury and regeneration. Curr. Neuropharmacol. 20(2), 344–361 (2022).
    • 21. Burrell JC, Browne KD, Dutton JL, Laimo FA, Das S, Brown DP et al. A porcine model of peripheral nerve injury enabling ultra-long regenerative distances: surgical approach, recovery kinetics, and clinical relevance. Neurosurgery 87(4), 833–846 (2020).
    • 22. Alvites RD, Branquinho MV, Sousa AC et al. Establishment of a sheep model for hind limb peripheral nerve injury: common peroneal nerve. Int. J. Mol. Sci. 22(3), 1401 (2021).
    • 23. Contreras E, Traserra S, Bolívar S, Forés J, Jose-Cunilleras E, Delgado-Martínez I et al. Repair of Long Peripheral Nerve Defects in Sheep: A Translational Model for Nerve Regeneration. Int. J. Mol. Sci. 24(2), 1333 (2023).