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Letter to the EditorFree Access

Future perspective on pharmacogenomics of severe hypoglycemia associated with sulfonylureas: reply from the authors

    Ryosuke Sato

    * Author for correspondence

    Department of Endocrinology & Metabolism, Division of Internal Medicine II, Hamamatsu University School of Medicine, Hamamatsu, Japan and Department of Endocrinology & Metabolism, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.

    ,
    Hiroshi Watanabe

    Department of Clinical Pharmacology & Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan

    ,
    Rieko Genma

    Department of Endocrinology & Metabolism, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

    ,
    Masahiro Takeuchi

    Reseach Center for Clinical Pharmacology, Kitasato University, Tokyo, Japan

    ,
    Masato Maekawa

    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

    &
    Hirotoshi Nakamura

    Department of Endocrinology & Metabolism, Division of Internal Medicine II, Hamamatsu University School of Medicine, Hamamatsu, Japan

    Published Online:https://doi.org/10.2217/pgs.11.163

    A letter in response to: Holstein JD, Kovacs P, Patzer O, Stumvoll M, Holstein A. The Ser1369Ala variant of ABCC8 and the risk for severe sulfonylurea-induced hypoglycemia in German patients with Type 2 diabetes. Pharmacogenomics 13(1), 5–7 (2012).

    References

    • Holstein JD, Kovacs P, Patzer O, Stumvoll M, Holstein A. The Ser1369Ala variant of ABCC8 and the risk for severe sulfonylurea-induced hypoglycemia in German patients with Type 2 diabetes. Pharmacogenomics13(1),5–7 (2012).
    • Sato R, Watanabe H, Genma R et al.ABCC8 polymorphism (Ser1369Ala): influence on severe hypoglycemia due to sulfonylureas. Pharmacogenomics11(12),1743–1750 (2010).
    • Chia CW, Egan JM. Incretin-based therapies in Type 2 diabetes mellitus. J. Clin. Endocrinol. Metab.93(10),3703–3716 (2008).
    • Seino S, Zhang CL, Shibasaki T. Sulfonylurea action re-revisited. J. Diabetes Invest.1(1–2),37–39 (2010).
    • Zhang CL, Katoh M, Shibasaki T et al. The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science325(5940),607–610 (2009).
    • Travers ME, McCarthy MI. Type 2 diabetes and obesity: genomics and the clinic. Hum. Genet.130(1),41–58 (2011).
    • 101  The Ministry of Health, Labour, and Welfare in Japan. Pharmaceuticals and Medical devices safety information. No. 275, December 2010 (In Japanese). www1.mhlw.go.jp/kinkyu/iyaku_j/iyaku_j/anzenseijyouhou/275.pdf