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Pharmacogenomics
Regenerative Medicine

Attitudes about pharmacogenomic testing vary by healthcare specialty

    Charlene L Preys

    MGH Institute of Health Professions, Charlestown, MA 02129, USA

    Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA

    ,
    Carrie L Blout Zawatsky

    Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA

    Ariadne Labs, Boston, MA 02215, USA

    ,
    Amanda Massmann

    Sanford Imagenetics, Sanford Health, Sioux Falls, SD 57105, USA

    Department of Internal Medicine, University of South Dakota School of Medicine, Vermilion, SD 57069, USA

    ,
    Joel Van Heukelom

    Sanford Imagenetics, Sanford Health, Sioux Falls, SD 57105, USA

    Department of Internal Medicine, University of South Dakota School of Medicine, Vermilion, SD 57069, USA

    ,
    Robert C Green

    Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA

    Ariadne Labs, Boston, MA 02215, USA

    Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA

    ,
    Catherine Hajek

    Sanford Imagenetics, Sanford Health, Sioux Falls, SD 57105, USA

    Helix OpCo, LLC, San Diego, CA 92121, USA

    ,
    Madison R Hickingbotham

    Precision Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA

    ,
    Emilie S Zoltick

    Precision Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA

    ,
    April Schultz

    *Author for correspondence: Tel.: +1 605 404 4371;

    E-mail Address: april.schultz@sanfordhealth.org

    Sanford Imagenetics, Sanford Health, Sioux Falls, SD 57105, USA

    Department of Internal Medicine, University of South Dakota School of Medicine, Vermilion, SD 57069, USA

    &
    Kurt D Christensen

    Ariadne Labs, Boston, MA 02215, USA

    Precision Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA

    Department of Population Medicine, Harvard Medical School, Boston, MA 02115, USA

    Published Online:https://doi.org/10.2217/pgs-2023-0039

    Aim: To understand how attitudes toward pharmacogenomic (PGx) testing among healthcare providers varies by specialty. Methods: Providers reported comfort ordering PGx testing and its perceived utility on web-based surveys before and after genetics education. Primary quantitative analyses compared primary care providers (PCPs) to specialty providers at both timepoints. Results: PCPs were more likely than specialty care providers to rate PGx testing as useful at both timepoints. Education increased comfort ordering PGx tests, with larger improvements among PCPs than specialty providers. Over 90% of cardiology and internal medicine providers rated PGx testing as useful at pre- and post-education. Conclusion: PCPs overwhelmingly perceive PGx to be useful, and provider education is particularly effective for improving PCPs' confidence. Education for all specialties will be essential to ensure appropriate integration into routine practice.

    Papers of special note have been highlighted as: • of interest

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