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Pharmacist-guided pharmacogenetic service lowered warfarin-related hospitalizations

    Kibum Kim

    *Author for correspondence: Tel.: +1 312 413 0152;

    E-mail Address: kkim204@uic.edu

    Department of Pharmacy Systems, Outcomes & Policy, University of Illinois Chicago, 833 S Wood St, Chicago, IL 60612, USA

    Center for Pharmacoepidemiology & Pharmacoeconomic Research, University of Illinois Chicago, 833 S Wood St, Chicago, IL 60612, USA

    ,
    Julio D Duarte

    Department of Pharmacotherapy & Translational Research & Center for Pharmacogenomics & Precision Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA

    ,
    William L Galanter

    Department of Medicine, University of Illinois Chicago, 840 S Wood St, Chicago, IL 60612, USA

    ,
    Jin Han

    Center for Pharmacoepidemiology & Pharmacoeconomic Research, University of Illinois Chicago, 833 S Wood St, Chicago, IL 60612, USA

    Department of Pharmacy Practice, University of Illinois Chicago, 833 Wood St, Chicago, IL 60612, USA

    ,
    James C Lee

    Department of Pharmacy Practice, University of Illinois Chicago, 833 Wood St, Chicago, IL 60612, USA

    ,
    Larisa H Cavallari

    Department of Pharmacotherapy & Translational Research & Center for Pharmacogenomics & Precision Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA

    &
    Edith A Nutescu

    Center for Pharmacoepidemiology & Pharmacoeconomic Research, University of Illinois Chicago, 833 S Wood St, Chicago, IL 60612, USA

    Department of Pharmacy Practice, University of Illinois Chicago, 833 Wood St, Chicago, IL 60612, USA

    Published Online:https://doi.org/10.2217/pgs-2023-0014

    Background: The authors aimed to assess outcomes with a pharmacogenetic (PGx)-informed, pharmacist-guided, personalized consult service for warfarin dosing. Methods: This retrospective cohort study included patients admitted with thromboembolic events. Eligible subjects received either PGx-informed (n = 389) or historical non-PGx pharmacist-guided warfarin dosing (Hx; n = 308) before hospital discharge. The composite of admission with bleeding or thromboembolic events over 90 days after the discharge was compared between the PGx and Hx groups. Results: The rate ratio (95% CI) of the composite of bleeding or thromboembolic admissions for PGx versus Hx was 0.32 (0.12–0.82). The estimated hazard ratio was 0.43 (0.16–1.12). Conclusion: A PGx-informed warfarin dosing service was associated with decreased bleeding and thromboembolic encounters.

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