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Regenerative Medicine

Gene polymorphisms affect postoperative imatinib plasma levels and edema in adults with gastrointestinal stromal tumor

    Xuehui Jiang

    School of Pharmacy, Nanchang University, Nanchang, 330000, China

    Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, China

    Department of Pharmacy, Xiang'an Hospital of Xiamen University, Xiamen, 361100, China

    ,
    Qun Fu

    Jiangxi Provincial Drug Inspector Center, Jiangxi Provincial Drug Administration, Nanchang, 330000, China

    ,
    Ying Kong

    Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, China

    ,
    Hong Liu

    Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, China

    ,
    Kaisaner Rexiti

    School of Pharmacy, Nanchang University, Nanchang, 330000, China

    Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, China

    ,
    Hongwei Peng

    Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, China

    ,
    Pin Xiao

    Department of Pharmacy, Hospital of Jiangxi Provincial Armed Police Corps, Nanchang, 330000, China

    &
    Xiaohua Wei

    *Author for correspondence:

    E-mail Address: 1083032243@qq.com

    Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, China

    Published Online:https://doi.org/10.2217/pgs-2022-0171

    Aim: To assess the role of genetic polymorphisms in postoperative imatinib concentrations and edema in patients with gastrointestinal stromal tumor. Methods: The relationships between genetic polymorphisms, imatinib concentrations and edema were explored. Results: Carriers of the rs683369 G-allele and rs2231142 T-allele had significantly higher imatinib concentrations. Grade ≥2 periorbital edemas were related to the carriership of two C-alleles in rs2072454 with an adjusted odds ratio of 2.85, two T-alleles in rs1867351 with an adjusted odds ratio of 3.42 and two A-alleles in rs11636419 with an adjusted odds ratio of 3.15. Conclusion: rs683369 and rs2231142 affect the metabolism of imatinib; rs2072454, rs1867351 and rs11636419 are related to grade ≥2 periorbital edemas.

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