Aim: This systematic review aimed to outline the outcome of OPRMI (A118G) variants on the effects of anesthetic and analgesic agents used in various procedures. Materials & methods: Literature was obtained from reliable, established databases and reference tracking. Efficacy and side/adverse effects of anesthetic and analgesic drugs intraoperatively or within 48 h postsurgery were the key outcome measures for all populations. Animal studies were excluded. Results: Twenty-nine studies were chosen for inclusion. In association with the efficacy and safety of anesthetic and analgesic agents, gene polymorphism in OPRM1 displayed a strong correlation in reduced analgesic effect and protection against adverse reactions. Conclusion: This systematic review summarized the correlation between genetic polymorphism in the OPRM1 gene and anesthetic/analgesic effects.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 23, No. 10

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History

Received 3 April 2022

Accepted 1 June 2022

Published online 23 June 2022

Published in print July 2022

Information

Keywords

Author contributions

M Makmor-Bakry was responsible for the study conception and design; L Yee and M Makmor-Bakry were responsible for the acquisition of data; L Yee, M Makmor-Bakry and FR Capule were responsible for data analysis and drafting and revision of the manuscript.

Financial & competing interests disclosure

This study was supported by the Fundamental Research Grant Scheme, Malaysian Ministry of Higher Education (FRGS/1/2019/SKK09/UKM/02/4). The authors have no other relevant afflictions or financial involvement with any organization or entity with a financial interest or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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