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Impact of the PEAR 1 polymorphism on clinical outcomes in Chinese patients receiving dual antiplatelet therapy after percutaneous coronary intervention

    Xinyuan Hu‡

    Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun, 130021, China

    ‡Authors contributed equally

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    ,
    Chaoxi Liu‡

    Department of Cardiology, The First Hospital of Jilin University, Changchun, 130021, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Mingyou Zhang

    Department of Cardiology, The First Hospital of Jilin University, Changchun, 130021, China

    &
    Weihua Zhang

    *Author for correspondence: Tel.: +86 1580 4300 983;

    E-mail Address: weihua@jlu.edu.cn

    Department of Cardiology, The First Hospital of Jilin University, Changchun, 130021, China

    Published Online:https://doi.org/10.2217/pgs-2022-0033

    Background: Patients might still experience major adverse cardiovascular events even with dual antiplatelet therapy after percutaneous coronary intervention. Our study aimed to explore the impact of gene polymorphism on clinical outcomes in one-year follow-up. Methods: A total of 171 patients treated with dual antiplatelet therapy after percutaneous coronary intervention from April to December 2020 in the first hospital of Jilin University enrolled in this study. Results: PEAR1 genetic polymorphisms was associated with the arachidonic acid (AA) and adenosine diphosphate (ADP) platelet aggregation. Hyperglycemia was associated with the rate of major adverse cardiovascular events. PEAR1 GA+AA genetic genetic polymorphisms is associated with hyperglycemia. Conclusion:PEAR1 GG is a risk factor for AA and ADP platelet aggregation. Hyperglycemia can effect the one-year outcome. PEAR1 GA+AA genetic polymorphisms are associated with hyperglycemia.

    References

    • 1. Neumann F, Sousa-Uva M, Ahlsson A et al. 2018 ESC/EACTS guidelines on myocardial revascularization. EuroIntervention 14(14), 1435–1534 (2019).
    • 2. Amin A, Sheau Chin L, Teh C et al. Pharmacometabolomics analysis of plasma to phenotype clopidogrel high on treatment platelets reactivity in coronary artery disease patients. Eur J Pharm Sci. 117, 351–361 (2018).
    • 3. Simon T, Verstuyft C, Mary-Krause M et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med. 360(4), 363–375 (2009).
    • 4. Hulot J, Bura A, Villard E et al. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood. 108(7), 2244–2247 (2006).
    • 5. Becker D, Segal J, Vaidya D et al. Sex differences in platelet reactivity and response to low-dose aspirin therapy. JAMA. 295(12), 1420–1427 (2006).
    • 6. Catella-Lawson F, Reilly MP, Kapoor SC et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N. Engl. J. Med. 345(25), 1809–1817 (2001).
    • 7. Xu K, Ye S, Zhang S et al. Impact of platelet endothelial aggregation receptor-1 genotypes on platelet reactivity and early cardiovascular outcomes in patients undergoing percutaneous coronary intervention and treated with aspirin and clopidogrel. Circ Cardiovasc Interv. 12(5), e007019 (2019).
    • 8. Li X, Ma N, Li X et al. Association of PON1, P2Y12 and COX1 with recurrent ischemic events in patients with extracranial or intracranial stenting. PLOS ONE 11(2), e0148891 (2016).
    • 9. Duconge J, Santiago E, Hernandez-Suarez D et al. Pharmacogenomic polygenic risk score for clopidogrel responsiveness among Caribbean Hispanics: a candidate gene approach. Clin. Transl. Sci. 14(6), 2254–2266 (2021).
    • 10. Nanda N, Bao M, Lin H et al. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J. Biol. Chem. 280(26), 24680–24689 (2005).
    • 11. Keramati A, Chen M, Rodriguez B et al. Genome sequencing unveils a regulatory landscape of platelet reactivity. Nat. Commun. 12(1), 3626 (2021).
    • 12. Faraday N, Yanek L, Yang X et al. Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression. Blood 118(12), 3367–3375 (2011).
    • 13. Li Z, Jiang H, Ding Y et al. Platelet endothelial aggregation receptor 1 polymorphism is associated with functional outcome in small-artery occlusion stroke patients treated with aspirin. Front Cardiovasc. Med. 8, 664012 (2021).
    • 14. Collet J, Cuisset T, Rangé G et al. Bedside monitoring to adjust antiplatelet therapy for coronary stenting. N. Engl. J. Med. 367(22), 2100–2109 (2012).
    • 15. Deng Q, Hou J, Deng X, Zhong ZJP. Association of serum laboratory parameters with periprocedural myocardial infarction after a primary percutaneous coronary intervention. Perfusion. 2676591211057502 (2022).
    • 16. Guo Y, Zhao J, Zhang Y et al. Triglyceride glucose index influences platelet reactivity in acute ischemic stroke patients. BMC Neurol. 21(1), 409 (2021).