Aim: To perform a systematic review to determine the effect of ABCB1 (1236C>T, 2677G>T/A and 3435C>T) variants on the effects of anesthetic and analgesic agents in various surgical procedures. Materials & methods: Literature was obtained from established databases and reference tracking. The main outcome measures were efficacy of anesthetic and analgesic agents intraoperative or within 48 h post surgery of human population. Results: Seventeen studies were included for data extraction from 1127 screened studies. The influences of ABCB1 gene polymorphisms on analgesic effects showed conflicting results. The mutational homozygous TT genotypes of 1236C>T and 3435C>T polymorphisms demonstrated significant association with the anesthetic effects. Conclusion: The mutational homozygous TT genotype in both ABCB1 1236C>T and 3435C>T is associated with weaker anesthetic effect but there are no clearly demonstrated analgesic effects.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 22, No. 16

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History

Received 23 June 2021

Accepted 13 September 2021

Published online 30 September 2021

Published in print November 2021

Information

Keywords

Author contributions

M Makmor-Bakry was responsible for the study conception and design; Y Liew and M Makmor-Bakry were responsible for the acquisition of data; Y Liew, M Makmor-Bakry and FR Capule were responsible for data analysis and drafting and revision of the manuscript.

Financial & competing interests disclosure

This study was supported by the Fundamental Research Grant Scheme, Malaysian Ministry of Higher Education (FRGS/1/2019/SKK09/UKM/02/4). The authors have no other relevant afflictions or financials involvement with any organization or entity with a financial interest or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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