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Is olaparib cost effective in metastatic castration-resistant prostate cancer patients with at least one favorable gene mutation in BRCA1, BRCA2 or ATM?

    Yiyuan Li‡

    Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Taijiang, Fuzhou, 350005, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Shen Lin‡

    Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Taijiang, Fuzhou, 350005, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Lixian Zhong

    College of Pharmacy, Texas A&M University, College Station, TX 77843-0000, USA

    ,
    Shaohong Luo

    Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Taijiang, Fuzhou, 350005, China

    ,
    Xiaoting Huang

    Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Taijiang, Fuzhou, 350005, China

    ,
    Xiaojia Huang

    Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Taijiang, Fuzhou, 350005, China

    ,
    Liangliang Dong

    Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Taijiang, Fuzhou, 350005, China

    ,
    Xiongwei Xu

    Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Taijiang, Fuzhou, 350005, China

    &
    Xiuhua Weng

    *Author for correspondence: Tel.: +861 596 001 5688;

    E-mail Address: wxh001@fjmu.edu.cn

    Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Taijiang, Fuzhou, 350005, China

    Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, The First Affiliated Hospital of Fujian Medical University, Taijiang, Fuzhou, 350005, China

    Published Online:https://doi.org/10.2217/pgs-2021-0061

    Aim: To compare the cost–effectiveness of olaparib versus control treatment in metastatic castration-resistant prostate cancer patients with at least one gene mutation in BRCA1, BRCA2 or ATM from the US payer perspective. Methods: A Markov model was constructed to assess the quality-adjusted life years (QALYs) and incremental cost–effectiveness ratios. Sensitivity analyses and scenario analyses were conducted to explore the impact of uncertainties. Results: The base-case result indicated that, for patients with specific gene mutations, olaparib gained 1.26 QALYs and USD$157,732 total cost. Compared with control treatment, the incremental cost–effectiveness ratio of olaparib was USD$248,248/QALY. The price of olaparib was the most influential parameter. Conclusion: Olaparib is not cost effective in comparison with control treatment in metastatic castration-resistant prostate cancer patients with specific gene mutations.

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