References
- 1. . RAS proteins and their regulators in human disease. Cell 170(1), 17–33 (2017).
- 2. . RAS-targeted therapies: is the undruggable drugged? Nat. Rev. Drug Discov. 19(8), 533–552 (2020).
- 3. . Comprehensive molecular profiling of lung adenocarcinoma. Nature 511(7511), 543–550 (2014).
- 4. . Comprehensive molecular characterization of human colon and rectal cancer. Nature 487(7407), 330–337 (2012).
- 5. . Integrated genomic characterization of pancreatic ductal adenocarcinoma. Cancer Cell 32(2), 185–203.e13 (2017).
- 6. . Distribution of KRASG12C somatic mutations across race, sex, and cancer type. N. Engl. J. Med. 384(2), 185–187 (2021).
- 7. . KRAS G12C-mutant non-small-cell lung cancer: biology, developmental therapeutics, and molecular testing. J. Mol. Diagn. 23(5), 507–520 (2021).
- 8. KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. Clin. Cancer Res. 13(10), 2890–2896 (2007).
- 9. Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer. Br. J. Cancer 116(7), 923–929 (2017).
- 10. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature 575(7781), 217–223 (2019).
- 11. KRASG12C inhibition with sotorasib in advanced solid tumors. N. Engl. J. Med. 383(13), 1207–1217 (2020).
- 12. IASLC. Sotorasib shows early activity against KRAS G12C mutant NSCLC. https://www.iaslc.org/iaslc-news/ilcn/sotorasib-shows-early-activity-against-kras-g12c-mutant-nsclc
- 13. The KRASG12C inhibitor MRTX849 provides insight toward therapeutic susceptibility of KRAS-mutant cancers in mouse models and patients. Cancer Discov. 10(1), 54–71 (2020).
- 14. KRYSTAL-1: activity and safety of adagrasib (MRTX849) in advanced/metastatic non-small-cell lung cancer (NSCLC) harboring KRAS G12C mutation. Eur. J. Cancer 138, S1–S2 (2020).
- 15. KRYSTAL-1: activity and safety of adagrasib (MRTX849) in patients with colorectal cancer (CRC) and other solid tumors harboring a KRAS G12C mutation. Eur. J. Cancer 138, S2 (2020).
- 16. EGFR blockade reverts resistance to KRASG12C inhibition in colorectal cancer. Cancer Discov. 10(8), 1129–1139 (2020).
- 17. Vertical pathway inhibition overcomes adaptive feedback resistance to KRASG12C inhibition. Clin. Cancer Res. 26(7), 1633–1643 (2020).
- 18. KRAS G12C NSCLC models are sensitive to direct targeting of KRAS in combination with PI3K inhibition. Clin. Cancer Res. 25(2), 796–807 (2019).
- 19. Clinical acquired resistance to KRASG12C inhibition through a novel KRAS switch-II pocket mutation and polyclonal alterations converging on RAS-MAPK reactivation. Cancer Discov.
doi:10.1158/2159-8290.CD-21-0365 (2021) (Epub ahead of print). - 20. . AACR Annual Meeting 2021 Online Proceedings and Itinerary Planner. Dana-Farber Cancer Institute, MA, USA. https://www.abstractsonline.com/pp8/#!/9325/presentation/4751