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Pharmacogenomics variants are associated with BMI differences between individuals with bipolar and other psychiatric disorders

    Aggeliki Charalampidi

    Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece

    ,
    Zoe Kordou

    Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece

    ,
    Evangelia-Eirini Tsermpini

    Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece

    ,
    Panagiotis Bosganas

    Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece

    ,
    Wasun Chantratita

    Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    ,
    Koya Fukunaga

    Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

    ,
    Taisei Mushiroda

    Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

    ,
    George P Patrinos

    Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece

    Zayed Center of Health Sciences, United Arab Emirates University, Al-Ain, UAE

    Department of Pathology, College of Medicine & Health Sciences, United Arab Emirates University, Al-Ain, UAE

    &
    Maria Koromina

    *Author for correspondence: Tel.: +30 261 096 2339;

    E-mail Address: mkoromina@upnet.gr

    Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece

    The Golden Helix Foundation, London, UK

    Published Online:https://doi.org/10.2217/pgs-2021-0012

    Aim: Regardless of the plethora of next-generation sequencing studies in the field of pharmacogenomics (PGx), the potential effect of covariate variables on PGx response within deeply phenotyped cohorts remains unexplored. Materials & methods: We explored with advanced statistical methods the potential influence of BMI, as a covariate variable, on PGx response in a Greek cohort with psychiatric disorders. Results: Nine PGx variants within UGT1A6, SLC22A4, GSTP1, CYP4B1, CES1, SLC29A3 and DPYD were associated with altered BMI in different psychiatric disorder groups. Carriers of rs2070959 (UGT1A6), rs199861210 (SLC29A3) and rs2297595 (DPYD) were also characterized by significant changes in the mean BMI, depending on the presence of psychiatric disorders. Conclusion: Specific PGx variants are significantly associated with BMI in a Greek cohort with psychiatric disorders.

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