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Pharmacogenetic tests and depressive symptom remission: a meta-analysis of randomized controlled trials

    Chad A Bousman

    *Author for correspondence: Tel.: +1 403 210 7273;

    E-mail Address: chad.bousman@ucalgary.ca

    Departments of Medical Genetics, Psychiatry, & Physiology & Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada

    Alberta Children's Hospital Research Institute, Calgary, Alberta T2N 1N4, Canada

    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada

    Authors contributed equally

    Search for more papers by this author

    ,
    Katarina Arandjelovic

    IMPACT SRC, School of Medicine, Deakin University, Geelong, Victoria, 3220, Australia

    Authors contributed equally

    Search for more papers by this author

    ,
    Serafino G Mancuso

    Department of Psychiatry, University of Melbourne, Melbourne, Victoria, 3220, Australia

    ,
    Harris A Eyre

    IMPACT SRC, School of Medicine, Deakin University, Geelong, Victoria, 3220, Australia

    Department of Psychiatry, University of Melbourne, Melbourne, Victoria, 3220, Australia

    Innovation Institute, Texas Medical Center, Houston, TX 77030, USA

    CNSDose LLC, Westlake Village, CA 91359, USA

    &
    Boadie W Dunlop

    Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA

    Published Online:https://doi.org/10.2217/pgs-2018-0142

    Aim: To conducted a systematic review and meta-analysis of prospective, randomized controlled trials (RCTs) that examined pharmacogenetic-guided decision support tools (DSTs) relevant to depressive symptom remission in major depressive disorder (MDD). Patients & methods: Random-effects meta-analysis was performed on RCTs that examined the effect of DSTs on remission rates in MDD. RCT quality was assessed using the Cochrane Collaboration Criteria. Results & conclusion: A total of 1737 eligible subjects from five RCTs were examined. Individuals receiving pharmacogenetic-guided DST therapy (n = 887) were 1.71 (95% CI: 1.17–2.48; p = 0.005) times more likely to achieve symptom remission relative to individuals who received treatment as usual (n = 850). Pharmacogenetic-guided DSTs might improve symptom remission among those with MDD.

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