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Research Article

Pilot study of targeting magnetic carbon nanotubes to lymph nodes

    Feng Yang*

    Pancreatic Disease Institute, Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

    ,
    Jianhua Hu*

    Department of Macromolecular Science, Key Laboratory of Molecular Engineering of Polymers Ministry of Education, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China

    *Both authors contruibuted equally.

    Search for more papers by this author

    ,
    Dong Yang

    Department of Macromolecular Science, Key Laboratory of Molecular Engineering of Polymers Ministry of Education, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China

    ,
    Jiang Long

    Pancreatic Disease Institute, Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

    ,
    Guopei Luo

    Pancreatic Disease Institute, Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

    ,
    Chen Jin

    † Author for correspondence

    Pancreatic Disease Institute, Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

    ,
    Xianjun Yu

    Pancreatic Disease Institute, Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

    ,
    Jin Xu

    Pancreatic Disease Institute, Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

    ,
    Changchun Wang

    Department of Macromolecular Science, Key Laboratory of Molecular Engineering of Polymers Ministry of Education, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China

    ,
    Quanxing Ni

    Pancreatic Disease Institute, Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

    &
    Deliang Fu

    Pancreatic Disease Institute, Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

    Published Online:https://doi.org/10.2217/nnm.09.5

    Aim: The lymphatic distribution of magnetic carbon nanotubes was studied in vivo and compared with magnetic-activated carbon particles, which were selectively taken up in the lymphatic channels and delivered to the regional lymph nodes. Material & methods: Magnetic multiwalled carbon nanotubes functionalized with poly(acrylic acid) (mMWNTs) and magnetic-activated carbon particles were subcutaneously injected in mice. The draining lymph nodes were harvested at different times postadministration to examine the lymphatic distribution of these particles. The short-term accumulation and toxicity of mMWNTs in the major organs were studied. Results: mMWNTs had the same properties of lymph node mapping as magnetic-activated carbon particles in mice independent of lymph node metastasis. The degree of black staining of lymph nodes and concentration of mMWNTs had a dose–response relationship. Aggregation of magnetic particles was found around the metastatic foci within the lymph nodes. Footpad injection of mMWNTs did not cause any obvious local or systemic toxicities, and no particle agglomerates were found in the major organs. Conclusion: The feasibility of targeting magnetic carbon nanotubes to lymph nodes was demonstrated and the results support further studies for their potential use in diagnosing and treating cancer.

    Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

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