Piezoelectric nanomaterials: latest applications in biomedicine and challenges in clinical translation

References

• 1. Wang X, Shi J. Piezoelectric nanogenerators for self-powered nanodevices. In: Piezoelectric Nanomaterials for Biomedical Applications. Ciofani GMenciassi A (Eds.), Springer-Verlag Berlin, Heidelberg, Germany, 135–172 (2012).
  Google Scholar
• 2. Cafarelli A, Marino A, Vannozzi L et al. Piezoelectric nanomaterials activated by ultrasound: the pathway from discovery to future clinical adoption. ACS Nano 15(7), 11066–11086 (2021).
  Medline CASGoogle Scholar
• 3. Kapat K, Shubhra QTH, Zhou M, Leeuwenburgh S. Piezoelectric nano-biomaterials for biomedicine and tissue regeneration. Adv. Funct. Mater. 30(44), 1909045 (2020).
  CASGoogle Scholar
• 4. Sezer N, Koç M. A comprehensive review on the state-of-the-art of piezoelectric energy harvesting. Nano Energy 80, 105567 (2021).
  CASGoogle Scholar
• 5. Tang Y, Wu C, Wu Z, Hu L, Zhang W, Zhao K. Fabrication and in vitro biological properties of piezoelectric bioceramics for bone regeneration. Sci. Rep. 7(1), 1–12 (2017).
  MedlineGoogle Scholar
• 6. Bera S, Mondal S, Xue B, Shimon LJW, Cao Y, Gazit E. Rigid helical-like assemblies from a self-aggregating tripeptide. Nat. Mater. 18(5), 503–509 (2019).
  Medline CASGoogle Scholar
• 7. Kholkin A, Amdursky N, Bdikin I, Gazit E, Rosenman G. Strong piezoelectricity in bioinspired peptide nanotubes. ACS Nano 4(2), 610–614 (2010).
  Medline CASGoogle Scholar
• 8. Wang X, Song J, Liu J, Zhong LW. Direct-current nanogenerator driven by ultrasonic waves. Science 316(5821), 102–105 (2007).
  Medline CASGoogle Scholar
• 9. Ciofani G, Danti S, D'Alessandro D et al. Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation. ACS Nano 4(10), 6267–6277 (2010).
  Medline CASGoogle Scholar
• 10. Marino A, Arai S, Hou Y et al. Piezoelectric nanoparticle-assisted wireless neuronal stimulation. ACS Nano 9(7), 7678–7689 (2015).
  Medline CASGoogle Scholar
• 11. Rojas C, Tedesco M, Massobrio P et al. Acoustic stimulation can induce a selective neural network response mediated by piezoelectric nanoparticles. J. Neural Eng. 15(3), 036016 (2018).
  MedlineGoogle Scholar
• 12. Genchi GG, Ceseracciu L, Marino A et al. P(VDF-TrFE)/BaTiO₃ nanoparticle composite films mediate piezoelectric stimulation and promote differentiation of SH-SY5Y neuroblastoma cells. Adv. Healthc. Mater. 5(14), 1808–1820 (2016).
  Medline CASGoogle Scholar
• 13. Liu L, Chen B, Liu K et al. Wireless manipulation of magnetic/piezoelectric micromotors for precise neural stem-like cell stimulation. Adv. Funct. Mater. 30(11), 1910108 (2020).
  CASGoogle Scholar
• 14. Kim T, Kim HJ, Choi W et al. Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound. Nat. Biomed. Eng. 7(2), 149–163 (2022).
  MedlineGoogle Scholar
• 15. Marino A, Genchi GG, Mattoli V, Ciofani G. Piezoelectric nanotransducers: the future of neural stimulation. Nano Today 14, 9–12 (2017).
  CASGoogle Scholar
• 16. Zhao D, Feng P-J, Liu J-H et al. Electromagnetized-nanoparticle-modulated neural plasticity and recovery of degenerative dopaminergic neurons in the mid-brain. Adv. Mater. 32(43), 2003800 (2020).
  CASGoogle Scholar
• 17. Ricotti L, Cafarelli A, Manferdini C et al. Ultrasound stimulation of piezoelectric nanocomposite hydrogels boosts chondrogenic differentiation in vitro, in both a normal and inflammatory milieu. ACS Nano 18(3), 2047–2065 (2024).
  Medline CASGoogle Scholar
• 18. Zhao F, Zhang C, Liu J et al. Periosteum structure/function-mimicking bioactive scaffolds with piezoelectric/chem/nano signals for critical-sized bone regeneration. Chem. Eng. J. 402, 126203 (2020).
  CASGoogle Scholar
• 19. Kaliannagounder VK, Raj NPMJ, Unnithan AR et al. Remotely controlled self-powering electrical stimulators for osteogenic differentiation using bone inspired bioactive piezoelectric whitlockite nanoparticles. Nano Energy 85, 105901 (2021).
  CASGoogle Scholar
• 20. Marino A, Battaglini M, De Pasquale D, Degl'Innocenti A, Ciofani G. Ultrasound-activated piezoelectric nanoparticles inhibit proliferation of breast cancer cells. Sci. Rep. 8(1), 6257 (2018).
  MedlineGoogle Scholar
• 21. Marino A, Almici E, Migliorin S et al. Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme. J. Colloid Interf. Sci. 538, 449–461 (2019).
  Medline CASGoogle Scholar
• 22. Pucci C, Marino A, Şen Ö et al. Ultrasound-responsive nutlin-loaded nanoparticles for combined chemotherapy and piezoelectric treatment of glioblastoma cells. Acta Biomater. 139, 218–236 (2022).
  Medline CASGoogle Scholar
• 23. Şen Ö, Marino A, Pucci C, Ciofani G. Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors. Mater. Today Bio. 13, 100196 (2022).
  Medline CASGoogle Scholar
• 24. Li C, Xiao C, Zhan L et al. Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization. Bioact. Mater. 18, 399–408 (2022).
  Medline CASGoogle Scholar
• 25. Wu M, Zhang Z, Liu Z et al. Piezoelectric nanocomposites for sonodynamic bacterial elimination and wound healing. Nano Today 37, 101104 (2021).
  CASGoogle Scholar
• 26. Zhao H, Xue S, Hussherr MD, Teixeira AP, Fussenegger M. Autonomous push button-controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant. Sci. Adv. 8(24), 4389 (2022).
  Google Scholar
• 27. Chen Y, Shi J, Yang G et al. High-performance sono-piezoelectric nanocomposites enhanced by interfacial coupling effects for implantable nanogenerators and actuators. Mater. Horizons 11(4), 995–1007 (2024).
  Medline CASGoogle Scholar
• 28. Dani SS, Tripathy A, Alluri NR, Balasubramaniam S, Ramadoss A. A critical review: the impact of electrical poling on the longitudinal piezoelectric strain coefficient. Mater. Adv. 3(24), 8886–8921 (2022).
  Google Scholar
• 29. Yu S, Milam-Guerrero JA, Tai Y et al. Maximizing polyacrylonitrile nanofiber piezoelectric properties through the optimization of electrospinning and post-thermal treatment processes. ACS Appl. Polym. Mater. 4(1), 635–644 (2022).
  CASGoogle Scholar
• 30. Han M, Yildiz E, Bozuyuk U et al. Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound. Nat. Commun. 15(1), 1–17 (2024).
  MedlineGoogle Scholar
• 31. Truong Hoang Q, Kim DY, Park HS et al. Oxygen-supplying piezocatalytic therapy of hypoxic tumors by intratumoral delivery of pH-responsive multicompartmental carriers with sequential drug release capability. Adv. Funct. Mater. 2306078 (2024).
  Google Scholar