Secondary metabolites in topical infectious diseases and nanomedicine applications

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1. Mohamed SA, Hargest R. Surgical anatomy of the skin. Surg. (United Kingdom) 40(1), 1–7 (2022).
  Google Scholar
• 2. Watkins K. Emerging infectious diseases: a review. Curr. Emerg. Hosp. Med. Rep. 6(3), 86–93 (2018).
  MedlineGoogle Scholar
• 3. Flohr C, Hay R. Putting the burden of skin diseases on the global map. Br. J. Dermatol. 184(2), 189–190 (2021).
  Medline CASGoogle Scholar
• 4. Baker RE, Mahmud AS, Miller IF et al. Infectious disease in an era of global change. Nat. Rev. Microbiol. 20(4), 193–205 (2022). • Review that presents information about infectious diseases across the globe.
  Medline CASGoogle Scholar
• 5. Satterthwaite D. The impact on health urban environments. Environ. Urban 5(2), 87–111 (1993).
  Medline CASGoogle Scholar
• 6. Gadre A, Enbiale W, Andersen LK, Coates SJ. The effects of climate change on fungal diseases with cutaneous manifestations: a report from the International Society of Dermatology Climate Change Committee. J. Clim. Chang. Heal. 6, 100156 (2022).
  Google Scholar
• 7. Sahni K, Singh S, Dogra S. Newer topical treatments in skin and nail dermatophyte infections. Indian Dermatol. Online J. 9(3), 149 (2018).
  MedlineGoogle Scholar
• 8. Lim SMS, Sinnollareddy M, Sime FB. Challenges in antifungal therapy in diabetes mellitus. J. Clin. Med. 9(9), 1–9 (2020).
  CASGoogle Scholar
• 9. Trovato L, Calvo M, De Pasquale R et al. Prevalence of onychomycosis in diabetic patients: a case-control study performed at University Hospital Policlinico in Catania. J. Fungi 8(9), 922 (2022).
  Google Scholar
• 10. Khalifa A, Alreshidi IG, Alaradi LA, Alrashidi YM. Tinea unguium and tinea pedis and their correlation with diabetes mellitus in the general population in the Hail Region, Saudi Arabia: a cross-sectional study. Cureus 15(5), e40116 (2023).
  MedlineGoogle Scholar
• 11. Kalra B, Kalra S. Vulvovaginitis and diabetes. J. Pak. Med. Assoc. 67(1), 143–145 (2017).
  MedlineGoogle Scholar
• 12. Unnikrishnan R, Misra A. Infections and diabetes: risks and mitigation with reference to India. Diabetes Metab. Syndr. Clin. Res. Rev. 14(6), 1889–1894 (2020).
  Google Scholar
• 13. Kennedy PGE, Mogensen TH, Cohrs RJ. Recent issues in varicella-zoster virus latency. Viruses 13(10), (2021).
  Google Scholar
• 14. Zhu S, Viejo-Borbolla A. Pathogenesis and virulence of herpes simplex virus. Virulence 12(1), 2670–2702 (2021).
  Medline CASGoogle Scholar
• 15. Meza-Romero R, Navarrete-Dechent C, Downey C. Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment. Clin. Cosmet. Investig. Dermatol. 12, 373–381 (2019).
  Medline CASGoogle Scholar
• 16. Pfeffermann K, Dörr M, Zirkel F, von Messling V. Morbillivirus pathogenesis and virus–host interactions. Adv. Virus Re. 100, 75–98 (2018).
  Medline CASGoogle Scholar
• 17. Bunge EM, Hoet B, Chen L et al. The changing epidemiology of human monkeypox – a potential threat? A systematic review. PLOS Negl. Trop. Dis. 16(2), e0010141 (2022).
  MedlineGoogle Scholar
• 18. Nelson CW, Mirabello L. Human papillomavirus genomics: understanding carcinogenicity. Tumour Virus Res. 15, 200258 (2023).
  Medline CASGoogle Scholar
• 19. Pantry SN, Medveczky PG. Latency, integration, and reactivation of human herpesvirus-6. Viruses 9(7), 194 (2017).
  MedlineGoogle Scholar
• 20. Rogo LD, Mokhtari-Azad T, Kabir MH, Rezaei F. Human parvovirus B19: a review. Acta Virol. 58(3), 199–213 (2014).
  Medline CASGoogle Scholar
• 21. Clark JM. New chemistries for the control of human head lice, Pediculus humanus capitis: a mini-review. Pestic. Biochem. Physiol. 181, 105013 (2022).
  Medline CASGoogle Scholar
• 22. Nardoni S, Mancianti F. Essential oils against Sarcoptes scabiei. Molecules 27(24), (2022).
  MedlineGoogle Scholar
• 23. Khais Muri Laabusi A, Mohsan Rhadi M. Prevalence of Pediculus humunus capitis, Pediculus humanus corporis, and Pthirus pubis in Al-Kut, Iraq. Arch. Razi Inst. 77(1), 497–501 (2022).
  MedlineGoogle Scholar
• 24. Mukai Y. Tunga penetrans in a sub-Saharan African desert traveler. Intern. Med. 59(19), 2441 (2020).
  MedlineGoogle Scholar
• 25. Reinhardt K. Bedbugs. Curr. Biol. 29(21), R1118–R1119 (2019).
  Medline CASGoogle Scholar
• 26. Lee N, Hwang S, Lee Y et al. Synthetic biology tools for novel secondary metabolite discovery in streptomyces. J. Microbiol. Biotechnol. 29(5), 667–686 (2019). • Presents the biological potential and medical use of secondary metabolites.
  Medline CASGoogle Scholar
• 27. Amparo TR, Seibert JB, de Vieira PMA et al. Herbal medicines to the treatment of skin and soft tissue infections: advantages of the multi-targets action. Phytother. Res. 34(1), 94–103 (2020).
  MedlineGoogle Scholar
• 28. Álvarez-Santos N, García-Bores AM, Barrera-Oviedo D et al. Secondary metabolites in wound healing: a review of their mechanisms of action. Stud. Nat. Prod. Chem. 78, 403–440 (2023).
  Google Scholar
• 29. Ubillas R, Jolad SD, Bruening RC et al. SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago). Phytomedicine 1(2), 77–106 (1994).
  Medline CASGoogle Scholar
• 30. Phatale V, Vaiphei KK, Jha S et al. Overcoming skin barriers through advanced transdermal drug delivery approaches. J. Control. Rel. 351, 361–380 (2022).
  Medline CASGoogle Scholar
• 31. Ray P, Singh S, Gupta S. Topical antimicrobial therapy: current status and challenges. Indian J. Med. Microbiol. 37(3), 299–308 (2019).
  MedlineGoogle Scholar
• 32. Goyal R, Macri LK, Kaplan HM, Kohn J. Nanoparticles and nanofibers for topical drug delivery. J. Control. Rel. 240, 77–92 (2016).
  Medline CASGoogle Scholar
• 33. Benson HAE, Grice JE, Mohammed Y et al. Topical and transdermal drug delivery: from simple potions to smart technologies. Curr. Drug Deliv. 16(5), 444–460 (2019).
  Medline CASGoogle Scholar
• 34. Ielciu I, Niculae M, Pall E et al. Antiproliferative and antimicrobial effects of Rosmarinus officinalis L. loaded liposomes. Molecules 27(13), (2022).
  Google Scholar
• 35. Azzazy HMES, Fahmy SA, Mahdy NK et al. Chitosan-coated PLGA nanoparticles loaded with peganum harmala alkaloids with promising antibacterial and wound healing activities. Nanomaterials (Basel) 11(9), 2438 (2021).
  Medline CASGoogle Scholar
• 36. Hou T, Guo Y, Han W et al. Exploring the biomedical applications of biosynthesized silver nanoparticles using Perilla frutescens flavonoid extract: antibacterial, antioxidant, and cell toxicity properties against colon cancer cells. Molecules 28(17), 6431 (2023).
  Medline CASGoogle Scholar
• 37. Ben-Khalifa R, Gaspar FB, Pereira C et al. Essential oil and hydrophilic antibiotic co-encapsulation in multiple lipid nanoparticles: proof of concept and in vitro activity against pseudomonas aeruginosa. Antibiotics (Basel) 10(11), 1300 (2021).
  Medline CASGoogle Scholar
• 38. Tiwari N, Osorio-Blanco ER, Sonzogni A et al. Nanocarriers for skin applications: where do we stand? Angew. Chemie – Int. Ed. 61(3), e202107960 (2022).
  Medline CASGoogle Scholar
• 39. Raina N, Rani R, Thakur VK, Gupta M. New insights in topical drug delivery for skin disorders: from a nanotechnological perspective. ACS Omega 8(22), 19145–19167 (2023).
  Medline CASGoogle Scholar
• 40. Demain AL, Fang A. The natural functions of secondary metabolites. Adv. Biochem. Eng. Biotechnol. 69, 1–39 (2000).
  Medline CASGoogle Scholar
• 41. Ozyigit II, Dogan II, Ozyigit AH et al. Production of secondary metabolites using tissue culture-based biotechnological applications. Front. Plant Sci. 14, 1132555 (2023).
  MedlineGoogle Scholar
• 42. Rodrigues V, Deusdado S. Meta-learning approach for bacteria classification and identification of informative genes of the Bacillus megaterium: tomato roots tissue interaction. 3 Biotech. 13(8), 271 (2023).
  MedlineGoogle Scholar
• 43. Demain AL, Fang A. The natural functions of secondary metabolites. Adv. Biochem. Eng. Biotechnol. 69, 1–39 (2000).
  Medline CASGoogle Scholar
• 44. Divekar PA, Narayana S, Divekar BA et al. Plant secondary metabolites as defense tools against herbivores for sustainable crop protection. Int. J. Mol. Sci. 23(5), 2690 (2022). •• Presents applications of secondary metabolites.
  Medline CASGoogle Scholar
• 45. Stevens M, Ruxton GD. The key role of behaviour in animal camouflage. Biol. Rev. 94(1), 116–134 (2019).
  MedlineGoogle Scholar
• 46. Choi JH, Jang AY, Lin S et al. Melittin, a honeybee venom-derived antimicrobial peptide, may target methicillin-resistant Staphylococcus aureus. Mol. Med. Rep. 12(5), 6483–6490 (2015).
  Medline CASGoogle Scholar
• 47. Kourany-lefoll E, Pais M, Sévenet T et al. Phloeodictines A and B: new antibacterial and cytotoxic bicyclic amidinium salts from the new caledonian sponge, Phloeodictyon sp. J. Org. Chem. 57(14), 3832–3835 (1992).
  CASGoogle Scholar
• 48. Huang L, Chen D, Wang L et al. Dermaseptin-PH: a novel peptide with antimicrobial and anticancer activities from the skin secretion of the south American orange-legged leaf frog, pithecopus (phyllomedusa) hypochondrialis. Molecules 22(10), 1805 (2017).
  MedlineGoogle Scholar
• 49. Wang Y, Hong J, Liu X et al. Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. PLOS ONE 3(9), e3217 (2008).
  MedlineGoogle Scholar
• 50. Kubota T, Ichiro KS, Kobayashi J. The manzamine alkaloids. In: Alkaloids: Chemistry and Biology. Cordell GA (Eds). Academic Press, CA, USA (2020).
  Google Scholar
• 51. Cariello L, Zanetti L, Cuomo V, Vanzanella F. Antimicrobial activity of avarol, a sesquiterpenoid hydroquinone from the marine sponge, dysidea avara. Comp. Biochem. Physiol. Part B Biochem. 71(2), 281–283 (1982).
  Medline CASGoogle Scholar
• 52. Cole AM, Weis P, Diamond G. Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder. J. Biol. Chem. 272(18), 12008–12013 (1997).
  Medline CASGoogle Scholar
• 53. Zhang M, Wei W, Sun Y et al. Pleurocidin congeners demonstrate activity against Streptococcus and low toxicity on gingival fibroblasts. Arch. Oral Biol. 70, 79–87 (2016).
  Medline CASGoogle Scholar
• 54. Jung HJ, Park Y, Sung WS et al. Fungicidal effect of pleurocidin by membrane-active mechanism and design of enantiomeric analogue for proteolytic resistance. Biochim. Biophys. Acta Biomembr. 1768(6), 1400–1405 (2007).
  CASGoogle Scholar
• 55. Aldawsari HM, Badr-Eldin SM, Labib GS, El-Kamel AH. Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: in vitro/in vivo evaluation. Int. J. Nanomed. 10, 893–902 (2015).
  MedlineGoogle Scholar
• 56. Ammar B, Périanin A, Mor A et al. Dermaseptin, a peptide antibiotic, stimulates microbicidal activities of polymorphonuclear leukocytes. Biochem. Biophys Res. Commun. 247(3), 870–875 (1998).
  Medline CASGoogle Scholar
• 57. Navon-Venezia S, Feder R, Gaidukov L et al. Antibacterial properties of dermaseptin S4 derivatives with in vivo activity. Antimicrob. Agents Chemother. 46(3), 689–694 (2002).
  Medline CASGoogle Scholar
• 58. Zhu H, Ding X, Li W et al. Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells. Peer J. 6, e5635 (2018).
  MedlineGoogle Scholar
• 59. Torres JP, Schmidt EW. The biosynthetic diversity of the animal world. J. Biol. Chem. 294(46), 17684–17692 (2019).
  Medline CASGoogle Scholar
• 60. Ruiz B, Chávez A, Forero A et al. Production of microbial secondary metabolites: regulation by the carbon source. Crit. Rev. Microbiol. 36(2), 146–167 (2010).
  Medline CASGoogle Scholar
• 61. Aruldass CA, Masalamany SRL, Venil CK, Ahmad WA. Antibacterial mode of action of violacein from Chromobacterium violaceum UTM5 against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). Environ. Sci. Pollut. Res. 25(6), 5164–5180 (2018). •• Demonstrates the sources of secondary metabolites from microorganisms.
  Medline CASGoogle Scholar
• 62. Kahlon N, Sharma A, Dogra H, Singh R. Quorum-sensing effector pyocyanin but not farnesol & acyl homoserine lactone exhibit antibacterial activity. Indian J. Med. Res. 155(1), 73–78 (2022).
  MedlineGoogle Scholar
• 63. Majeed HZ. Antimicrobial activity of Micrococcus luteus cartenoid pigment. Al-Mustansiriyah J. Sci. 28(1), 64–69 (2017).
  Google Scholar
• 64. Selim MSM, Abdelhamid SA, Mohamed SS. Secondary metabolites and biodiversity of actinomycetes. J. Genet. Eng. Biotechnol. 19(1), 72 (2021).
  MedlineGoogle Scholar
• 65. Jakubiec-Krzesniak K, Rajnisz-Mateusiak A, Guspiel A et al. Secondary metabolites of actinomycetes and their antibacterial, antifungal and antiviral properties. Polish J. Microbiol. 67(3), 259–272 (2018).
  MedlineGoogle Scholar
• 66. Din FU, Aman W, Ullah I et al. Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int. J. Nanomed. 12, 7291–7309 (2017).
  MedlineGoogle Scholar
• 67. Reddy GKK, Padmavathi AR, Nancharaiah YV. Fungal infections: pathogenesis, antifungals and alternate treatment approaches. Curr. Res. Microb. Sci. 3, 100137 (2022).
  Medline CASGoogle Scholar
• 68. Bonifácio BV, da Silva PB, Aparecido dos Santos Ramos M et al. Nanotechnology-based drug delivery systems and herbal medicines: a review. Int. J. Nanomed. 9(1), 1–15 (2013).
  MedlineGoogle Scholar
• 69. Esposito E, Nastruzzi C, Sguizzato M, Cortesi R. Nanomedicines to treat skin pathologies with natural molecules. Curr. Pharm. Des. 25(21), 2323–2337 (2019).
  Medline CASGoogle Scholar
• 70. Cardoso RV, Pereira PR, Freitas CS, Paschoalin VMF. Trends in drug delivery systems for natural bioactive molecules to treat health disorders: the importance of nano-liposomes. Pharmaceutics 14(12), 2808 (2022).
  Medline CASGoogle Scholar
• 71. Turuvekere Vittala Murthy N, Agrahari V, Chauhan H. Polyphenols against infectious diseases: controlled release nano-formulations. Eur. J. Pharm. Biopharm. 161, 66–79 (2021).
  MedlineGoogle Scholar
• 72. Souto EB, Cano A, Martins-Gomes C et al. Microemulsions and nanoemulsions in skin drug delivery. Bioengineering 9(4), 158 (2022).
  Medline CASGoogle Scholar
• 73. Zhu W, Yu A, Wang W et al. Formulation design of microemulsion for dermal delivery of penciclovir. Int. J. Pharm. 360(1–2), 184–190 (2008).
  Medline CASGoogle Scholar
• 74. Wichterle O, Lím D. Hydrophilic gels for biological use. Nature 185(4706), 117–118 (1960).
  Google Scholar
• 75. Ahmed EM. Hydrogel: preparation, characterization, and applications: a review. J. Adv. Res. 6(2), 105–121 (2015).
  Medline CASGoogle Scholar
• 76. Almoshari YH. Novel hydrogels for topical applications: an updated comprehensive review based on source. Gels 8(3), 174 (2022).
  Medline CASGoogle Scholar
• 77. Mardhiah Adib Z, Ghanbarzadeh S, Kouhsoltani M et al. The effect of particle size on the deposition of solid lipid nanoparticles in different skin layers: a histological study. Adv. Pharm. Bull. 6(1), 31–36 (2016).
  MedlineGoogle Scholar
• 78. Mehnert W, Mäder K. Solid lipid nanoparticles: production, characterization and applications. Adv. Drug Deliv. Rev. 64(Suppl.), 83–101 (2012).
  Google Scholar
• 79. Ramzan M, Gourion-Arsiquaud S, Hussain A et al. In vitro release, ex vivo penetration, and in vivo dermatokinetics of ketoconazole-loaded solid lipid nanoparticles for topical delivery. Drug Deliv. Transl. Res. 12(7), 1659–1683 (2022).
  Medline CASGoogle Scholar
• 80. Baveloni FG, Riccio BVF, Di Filippo LD et al. Nanotechnology-based drug delivery systems as potential for skin application: a review. Curr. Med. Chem. 28(16), 3216–3248 (2020).
  Google Scholar
• 81. Madawi EA, Al Jayoush AR, Rawas-Qalaji M et al. Polymeric nanoparticles as tunable nanocarriers for targeted delivery of drugs to skin tissues for treatment of topical skin diseases. Pharmaceutics 15(2), 657 (2023).
  Medline CASGoogle Scholar
• 82. Iqubal MK, Saleem S, Iqubal A et al. Natural, synthetic and their combinatorial nanocarriers based drug delivery system in the treatment paradigm for wound healing via dermal targeting. Curr. Pharm. Des. 26(36), 4551–4568 (2020).
  Medline CASGoogle Scholar
• 83. Pal N, Agarwal M, Gupta R. Green synthesis of guar gum/Ag nanoparticles and their role in peel-off gel for enhanced antibacterial efficiency and optimization using RSM. Int. J. Biol. Macromol. 221, 665–678 (2022).
  Medline CASGoogle Scholar
• 84. Sonia SS, Linda Jeeva Kumari H, Ruckmani RK, Sivakumar SM. Antimicrobial and antioxidant potentials of biosynthesized colloidal zinc oxide nanoparticles for a fortified cold cream formulation: a potent nanocosmeceutical application. Mater. Sci. Eng. C. 79, 581–589 (2017).
  Medline CASGoogle Scholar
• 85. Usach I, Margarucci E, Manca ML et al. Comparison between citral and pompia essential oil loaded in phospholipid vesicles for the treatment of skin and mucosal infections. Nanomaterials 10(2), 286 (2020).
  Medline CASGoogle Scholar
• 86. Jummes B, Sganzerla WG, da Rosa CG et al. Antioxidant and antimicrobial poly-ϵ-caprolactone nanoparticles loaded with Cymbopogon martinii essential oil. Biocatal. Agric. Biotechnol. 23, 101499 (2020).
  Google Scholar
• 87. Mandal AK, Sahoo A, Dwivedi K et al. Potential therapeutic application of biophenols-plants secondary metabolites in rheumatoid arthritis. Crit. Rev. Food Sci. Nutr. 63(27), 8900–8918 (2023).
  Medline CASGoogle Scholar
• 88. Akbar MU, Zia KM, Nazir A et al. Pluronic-based mixed polymeric micelles enhance the therapeutic potential of curcumin. AAPS Pharm. Sci. Tech. 19(6), 2719–2739 (2018).
  Medline CASGoogle Scholar
• 89. George D, Maheswari PU, Begum KMMS. Synergic formulation of onion peel quercetin loaded chitosan-cellulose hydrogel with green zinc oxide nanoparticles towards controlled release, biocompatibility, antimicrobial and anticancer activity. Int. J. Biol. Macromol. 132, 784–794 (2019).
  Medline CASGoogle Scholar
• 90. Anwar A, Masri A, Rao K et al. Antimicrobial activities of green synthesized gums-stabilized nanoparticles loaded with flavonoids. Sci. Rep. 9(1), 3122 (2019).
  MedlineGoogle Scholar
• 91. Narayanan M, Hussain F, Ahamed J et al. Green synthesizes and characterization of copper-oxide nanoparticles by Thespesia populnea against skin-infection causing microbes. J. King Saud Univ. Sci. 34(3), 101885 (2022).
  Google Scholar
• 92. Karthikeyan A, Senthil N, Min T. Nanocurcumin: a promising candidate for therapeutic applications. Front. Pharmacol. 11, 487 (2020).
  Medline CASGoogle Scholar
• 93. Comotto M, Saghazadeh S, Bagherifard S et al. Breathable hydrogel dressings containing natural antioxidants for management of skin disorders. J. Biomater. Appl. 33(9), 1265–1276 (2019).
  Medline CASGoogle Scholar
• 94. Pinho E, Henriques M, Soares G. Caffeic acid loading wound dressing: physicochemical and biological characterization. Ther. Deliv. 5(10), 1063–1075 (2014).
  Medline CASGoogle Scholar
• 95. Umadevi A, Kumari C, Kumar PA et al. Development and evaluation of polyherbal gel for antifungal activity. Int. J. Curr. Pharm. Res. 10(5), 40–43 (2018).
  CASGoogle Scholar
• 96. Sasivimolphan P, Lipipun V, Ritthidej G et al. Microemulsion-based oxyresveratrol for topical treatment of herpes simplex virus (HSV) infection: physicochemical properties and efficacy in cutaneous HSV-1 infection in mice. AAPS Pharm. Sci. Tech. 13(4), 1266–1275 (2012).
  Medline CASGoogle Scholar
• 97. Rahman M, Singh JG, Afzal O et al. Preparation, characterization, and evaluation of curcumin-graphene oxide complex-loaded liposomes against Staphylococcus aureus in topical disease. ACS Omega 7(48), 43499–43509 (2022). •• Presents the application of curcumin as an antimicrobial application.
  Medline CASGoogle Scholar
• 98. Hazzah HA, Farid RM, Nasra MMA et al. Gelucire-based nanoparticles for curcumin targeting to oral mucosa: preparation, characterization, and antimicrobial activity assessment. J. Pharm. Sci. 104(11), 3913–3924 (2015).
  Medline CASGoogle Scholar
• 99. Mohamed NH, Ismail MA, Abdel-Mageed WM, Shoreit AAM. Antimicrobial activity of green silver nanoparticles from endophytic fungi isolated from Calotropis procera (Ait) latex. Microbiol. (United Kingdom) 165(9), 967–975 (2019).
  MedlineGoogle Scholar
• 100. Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet 361–372 (2012).
  MedlineGoogle Scholar
• 101. Leelaudomlipi P, Intawong S, Supakdamrongkul P, Sobharaksha P. Preparation of nanostructured lipid carriers (Nlcs) loading violacein extract for anti-acne products. Key Eng. Mater. 129–136 (2021).
  Google Scholar
• 102. Gonçalves T, Vasconcelos U. Colour me blue: the history and the biotechnological potential of pyocyanin. Molecules 26(4), 927 (2021).
  Medline CASGoogle Scholar
• 103. Da Silva JEG, Do Amaral IPG, de Kretzschmar EAM, Vasconcelos U. Antifungal coating based on pyocyanin nanoparticles (Np-Pyo). Eur. J. Biol. Biotechnol. 3(2), 30–37 (2022).
  Google Scholar
• 104. Reis CP, Martinho N, Rosado C et al. Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment. Drug Dev. Ind. Pharm. 40(3), 409–417 (2014).
  Medline CASGoogle Scholar
• 105. Wang Y, Li Z, Xu M et al. Signal molecules regulate the synthesis of secondary metabolites in the interaction between endophytes and medicinal plants. Processes 11(3), 849 (2023).
  CASGoogle Scholar
• 106. Lin M, Guo JT. New insights into protein-DNA binding specificity from hydrogen bond based comparative study. Nucleic Acids Res. 47(21), 11103–11113 (2019).
  Medline CASGoogle Scholar
• 107. Divekar PA, Narayana S, Divekar BA et al. Plant secondary metabolites as defense tools against herbivores for sustainable crop protection. Int. J. Mol. Sci. 23(5), 2690 (2022).
  Medline CASGoogle Scholar
• 108. Wink M. Molecular modes of action of cytotoxic alkaloids: from DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance. Alkaloids Chem. Biol. 64, 1–47 (2007).
  Medline CASGoogle Scholar
• 109. Dai J, Mumper RJ. Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15(10), 7313–7352 (2010).
  Medline CASGoogle Scholar
• 110. Parvez MK, Rishi V. Herb-drug interactions and hepatotoxicity. Curr. Drug Metab. 20(4), 275–282 (2019).
  Medline CASGoogle Scholar
• 111. Pignatello R, Musumeci T, Basile L et al. Biomembrane models and drug-biomembrane interaction studies: involvement in drug design and development. J. Pharm. Bioallied Sci. 3(1), 4–14 (2011).
  Medline CASGoogle Scholar
• 112. Naylor MR, Ly AM, Handford MJ et al. Lipophilic permeability efficiency reconciles the opposing roles of lipophilicity in membrane permeability and aqueous solubility. J. Med. Chem. 61(24), 11169–11182 (2018).
  Medline CASGoogle Scholar
• 113. Huchzermeyer B, Menghani E, Khardia P, Shilu A. Metabolic pathway of natural antioxidants, antioxidant enzymes and ROS providence. Antioxidants (Basel) 11(4), 761 (2022).
  Medline CASGoogle Scholar
• 114. Zhao Y, Tian Y, Cui Y et al. Small molecule-capped gold nanoparticles as potent antibacterial agents that target Gram-negative bacteria. J. Am. Chem. Soc. 132(35), 12349–12356 (2010).
  Medline CASGoogle Scholar
• 115. Lee H, Lee DG. Gold nanoparticles induce a reactive oxygen species-independent apoptotic pathway in Escherichia coli. Colloids Surf. B Biointerfaces 167, 1–7 (2018).
  MedlineGoogle Scholar
• 116. Fan C, Moews PC, Walsh CT, Knox JR. Vancomycin resistance: structure of D-alanine: D-alanine ligase at 2.3 Å resolution. Science (80) 266(5184), 439–443 (1994).
  Medline CASGoogle Scholar
• 117. Hayden SC, Zhao G, Saha K et al. Aggregation and interaction of cationic nanoparticles on bacterial surfaces. J. Am. Chem. Soc. 134(16), 6920–6923 (2012).
  Medline CASGoogle Scholar
• 118. Engstrom AM, Faase RA, Marquart GW et al. Size-dependent interactions of lipid-coated gold nanoparticles: developing a better mechanistic understanding through model cell membranes and in vivo toxicity. Int. J. Nanomed. 15, 4091–4104 (2020).
  Medline CASGoogle Scholar
• 119. Li Q, Mahendra S, Lyon DY et al. Antimicrobial nanomaterials for water disinfection and microbial control: potential applications and implications. Water Res. 42(18), 4591–4602 (2008).
  Medline CASGoogle Scholar
• 120. Khan FU, Chen Y, Khan NU et al. Visible light inactivation of E. coli, cytotoxicity and ROS determination of biochemically capped gold nanoparticles. Microb. Pathog. 107, 419–424 (2017).
  MedlineGoogle Scholar
• 121. Jazmín Silvero MC, Rocca DM, Artur de la Villarmois E et al. Selective photoinduced antibacterial activity of amoxicillin-coated gold nanoparticles: from one-step synthesis to in vivo cytocompatibility. ACS Omega 3(1), 1220–1230 (2018).
  MedlineGoogle Scholar
• 122. Mora-Huertas CE, Fessi H, Elaissari A. Polymer-based nanocapsules for drug delivery. Int. J. Pharm. 385(1–2), 113–142 (2010).
  Medline CASGoogle Scholar
• 123. Gelperina S, Kisich K, Iseman MD, Heifets L. The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis. Am. J. Respir. Crit. Care Med. 172(12), 1487–1490 (2005).
  MedlineGoogle Scholar
• 124. Nel AE, Mädler L, Velegol D et al. Understanding biophysicochemical interactions at the nano-bio interface. Nat. Mater. 8(7), 543–557 (2009).
  Medline CASGoogle Scholar
• 125. Lademann J, Richter H, Teichmann A et al. Nanoparticles – an efficient carrier for drug delivery into the hair follicles. Eur. J. Pharm. Biopharm. 66(2), 159–164 (2007).
  Medline CASGoogle Scholar
• 126. De Stefano D, Carnuccio R, Maiuri MC. Nanomaterials toxicity and cell death modalities. J. Drug Deliv. 2012, 1–14 (2012).
  Google Scholar
• 127. Labouta HI, el-Khordagui LK, Kraus T, Schneider M. Mechanism and determinants of nanoparticle penetration through human skin. Nanoscale 3(12), 4989–4999 (2011).
  Medline CASGoogle Scholar
• 128. Wang S, Lu W, Tovmachenko O et al. Challenge in understanding size and shape dependent toxicity of gold nanomaterials in human skin keratinocytes. Chem. Phys. Lett. 463(1–3), 145–149 (2008).
  Medline CASGoogle Scholar
• 129. Shah PP, Desai PR, Patel AR, Singh MS. Skin permeating nanogel for the cutaneous co-delivery of two anti-inflammatory drugs. Biomaterials 33(5), 1607–1617 (2012).
  Medline CASGoogle Scholar
• 130. Prasath S, Palaniappan K. Is using nanosilver mattresses/pillows safe? A review of potential health implications of silver nanoparticles on human health. Environ. Geochem. Health 41(5), 2295–2313 (2019).
  Medline CASGoogle Scholar
• 131. Labouta HI, Liu DC, Lin LL et al. Gold nanoparticle penetration and reduced metabolism in human skin by toluene. Pharm. Res. 28(11), 2931–2944 (2011).
  Medline CASGoogle Scholar
• 132. Edlich A, Gerecke C, Giulbudagian M et al. Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin. Eur. J. Pharm. Biopharm. 116, 155–163 (2017).
  Medline CASGoogle Scholar
• 133. Mangalathillam S, Rejinold NS, Nair A et al. Curcumin loaded chitin nanogels for skin cancer treatment via the transdermal route. Nanoscale 4(1), 239–250 (2012).
  Medline CASGoogle Scholar
• 134. Zellner R. Biological responses to nanoscale particles. Beilstein J. Nanotechnol. 6(1), 380–382 (2015).
  Medline CASGoogle Scholar
• 135. Lu W, Senapati D, Wang S et al. Effect of surface coating on the toxicity of silver nanomaterials on human skin keratinocytes. Chem. Phys Lett. 487(1–3), 92–96 (2010).
  CASGoogle Scholar
• 136. Schaudinn C, Dittmann C, Jurisch J et al. Development, standardization and testing of a bacterial wound infection model based on ex vivo human skin. PLOS ONE 12(11), e0186946 (2017).
  MedlineGoogle Scholar