Research Article

Astragalus arbusculinus gum nanofibers

Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, 74877-94149, Iran

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Amir Mahdi Molavi

https://orcid.org/0000-0003-3054-1767

Department of Materials Research, Iranian Academic Center for Education, Culture & Research (ACECR), Khorasan Razavi Branch, Mashhad, 9177-948974, Iran

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Amir Amani

https://orcid.org/0000-0003-4302-6270

Natural Products & Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, 74877-94149, Iran

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Kurosh Hamzanlui Moqadam

https://orcid.org/0009-0008-5578-876X

North Khorasan University of Medical Sciences, Bojnurd, 74877-94149, Iran

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Mehran Vatanchian

https://orcid.org/0000-0001-8656-1981

Department of Anatomical Sciences School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, 74877-94149, Iran

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Seyyed Ahmad Hashemi

https://orcid.org/0000-0001-5161-4289

Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, 74877-94149, Iran

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Fatemeh Oroojalian

*Author for correspondence:

E-mail Address: f.oroojalian@gmail.com

https://orcid.org/0000-0002-6849-6853

Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, 74877-94149, Iran

Natural Products & Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, 74877-94149, Iran

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Published Online:31 Jan 2024https://doi.org/10.2217/nnm-2023-0311

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Abstract

Aim: Silk fibroin/chitosan/ZnO/Astragalus arbusculinus (Ast) gum fibrous scaffolds along with adipose-derived mesenchymal stem cells (ADSCs) were investigated for accelerating diabetic wound healing. Methods: Scaffolds with a core–shell structure and different compositions were synthesized using the electrospinning method. Biological in vitro investigations included antibacterial testing, cell viability analysis and cell attachment evaluation. In vivo experiments, including the chicken chorioallantoic membrane (CAM) test, were conducted to assess wound-healing efficacy and histopathological changes. Results: The incorporation of Ast to the silk fibroin@ chitosan/ZnO scaffold improved wound healing in diabetic mice. In addition, seeding of ADSCs on the scaffold accelerated wound healing. Conclusion: These findings suggest that the designed scaffold can be useful for skin regeneration applications.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 19, No. 6

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History

Received 26 October 2023

Accepted 8 January 2024

Published online 31 January 2024

Published in print March 2024

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Keywords

Financial disclosure

This work was supported by North Khorasan University of Medical Sciences, Bojnurd, Iran (grant no. 4000254). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The present research was approved by the ethics committee of North Khorasan University of Medical Sciences, Bojnurd, Iran (ethics approval COD no. IR.NKUMS.AEC.1401.001).

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