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Layered double hydroxide nanocarriers: potential delivery systems for mefenamic acid

    Parteek Prasher‡

    *Author for correspondence:

    E-mail Address: parteekchemistry@gmail.com

    Department of Chemistry, University of Petroleum & Energy Studies, Energy Acres, Dehradun, 248007, India

    ‡Authors contributed equally

    Search for more papers by this author

    &
    Mousmee Sharma‡

    Department of Chemistry, Uttaranchal University, Dehradun, 248007, India

    ‡Authors contributed equally

    Search for more papers by this author

    Published Online:https://doi.org/10.2217/nnm-2023-0217

    Tweetable abstract

    Layered double hydroxide nanocarriers are capable of intercalating hydrophobic NSAIDs, such as mefenamic acid, which improves their pharmacokinetics and bioavailability.

    References

    • 1. Grillo MP, Lohr MT, Wait JCM. Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat. Drug Metab. Dispos. 40(8), 1515–1526 (2012).
    • 2. Graham GG. Fenamates. In: Compendium of Inflammatory Diseases. Parnham MJ (Eds). Springer, Basel, Switzerland (2016).
    • 3. Drini M. Peptic ulcer disease and non-steroidal anti-inflammatory drugs. Aust. Prescr. 40(3), 91–93 (2017).
    • 4. Mishra G, Dash B, Pandey S. Layered double hydroxides: a brief review from fundamentals to applications as evolving biomaterials. Appl. Clay Sci. 153, 172–186 (2018).
    • 5. Kameliya J, Verma A, Dutta P, Arora C, Vyas S, Varma RS. Layered double hydroxide materials: a review on their preparation, characterization, and applications. Inorganics (MDPI) 11(3), 121 (2023).
    • 6. Rives V, Arco M, Martin C. Layered double hydroxides as drug carriers and for controlled release of non-steroidal anti-inflammatory drugs (NSAIDs): a review. J. Control. Rel. 169(1–2), 28–39 (2013).
    • 7. Arco MD, Fernandez A, Martin C, Sayalero ML, Rives V. Solubility, and release of fenamates intercalated in layered double hydroxides. Clay Minerals 43(2), 255–265 (2008).
    • 8. Arco MD, Fernandez A, Martin C, Rives V. Release studies of different NSAIDs encapsulated in Mg, Al, Fe-hydrotalcites. Appl. Clay Sci. 42, 538–544 (2009).
    • 9. Richardson-Chong SSD, Patel R, Williams GR. Intercalation, and controlled release of bioactive ions using a hydroxy double salt. Ind. Eng. Chem. Res. 51(7), 2913–2921 (2012).
    • 10. Cunha VRR, Guilherme VA, Paula E et al. Delivery system for mefenamic acid based on the nanocarrier layered double hydroxide: physicochemical characterization and evaluation of anti-inflammatory and antinociceptive potential. Mater. Sci. Eng. C 58, 629–638 (2016).
    • 11. Psenicka M, Skoda J, Pospisil M. Structural arrangement, and properties of layered double hydroxide drug nanocarrier intercalated by sulindac and mefenamic acid solved by molecular simulation methods. Appl. Clay Sci. 189, 105560 (2020).
    • 12. Sichani SB, Mansournia M. A novel approach to magnetic core–shell nanostructures of MgAl layered double hydroxide for controlled drug release of mefenamic acid. SSRN doi:10.2139/ssrn.4387186 (2023) (Preprint).
    • 13. Abniki M, Moghimi A. Synthesis of calcium-layered double hydroxide based nanohybrid for controlled release of an anti-inflammatory drug. J. Chin. Chem. Soc. 68(2), 343–352 (2021).