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Research Article

Tannic-acid-mediated synthesis and characterization of magnetite–gold nanoplatforms for photothermal therapy

    Marta Miola

    *Author for correspondence: Tel.: +39 011 090 4717;

    E-mail Address: marta.miola@polito.it

    Department of Applied Science & Technology, Politecnico di Torino, Torino, 10129, Italy

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    ,
    Cristina Multari

    Department of Applied Science & Technology, Politecnico di Torino, Torino, 10129, Italy

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    ,
    Nina Kostevšek

    Department for Nanostructured Materials, Jožef Stefan Institute, Ljubljana, 1000, Slovenia

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    ,
    Roberto Gerbaldo

    Department of Applied Science & Technology, Politecnico di Torino, Torino, 10129, Italy

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    ,
    Francesco Laviano

    Department of Applied Science & Technology, Politecnico di Torino, Torino, 10129, Italy

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    &
    Enrica Verné

    Department of Applied Science & Technology, Politecnico di Torino, Torino, 10129, Italy

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    Published Online:6 Oct 2023https://doi.org/10.2217/nnm-2023-0134

    Abstract

    Aim: The design of new hybrid nanoplatforms (HNPs) through the innovative and eco-friendly use of tannic acid (TA) for the synthesis and stabilization of the nanoplatforms. Materials & methods: The size, morphology, composition and magnetic and plasmonic properties of HNPs were investigated together with their ability to generate heat under laser irradiation and the hemotoxicity to explore their potential use for biomedical applications. Results & conclusion: The use of TA allowed the synthesis of the HNPs by adopting a simple and green method. The HNPs preserved the peculiar properties of both magnetic and plasmonic nanoparticles and did not show any hemotoxic effect.

    Plain language summary

    The aim of this research was to prepare new nanoparticles (called nanoplatforms) made from two parts: a magnetic core and the addition of gold particles. These particles can be used for cancer treatment because, when stimulated by light, they are able to release heat, which can kill cancer cells. In particular, in this work, we investigated the preparation of these particles using green methods, without the use of toxic reagents. The obtained nanoparticles were studied to investigate their size, shape, composition, magnetic properties, ability to generate heat and possible toxic effect toward blood cells. The results show that these particles can be produced with green methods, release heat and are not toxic.

    Papers of special note have been highlighted as: • of interest

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