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Research Article

Electrospun polyvinyl alcohol/Withania somnifera extract nanofibers incorporating tadalafil-loaded nanoparticles for diabetic ulcers

    Asmaa M Elsherbini

    Department of Biotechnology, Institute of Graduate Studies & Research, Alexandria University, Alexandria, 21526, Egypt

    ,
    Sally A Sabra

    *Author for correspondence: Tel.: +20 3429 5007;

    E-mail Address: ssabra@alexu.edu.eg

    Department of Biotechnology, Institute of Graduate Studies & Research, Alexandria University, Alexandria, 21526, Egypt

    ,
    Shimaa A Rashed

    Department of Botany& Microbiology, Faculty of Science, Alexandria University, Alexandria, 21568, Egypt

    ,
    Doaa A Abdelmonsif

    Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, 21131, Egypt 4 Department of Medical Biophysics, Medical Research Institute, Alexandria University, Alexandria, 21561, Egypt

    ,
    Medhat Haroun

    Department of Biotechnology, Institute of Graduate Studies & Research, Alexandria University, Alexandria, 21526, Egypt

    &
    Thanaa I Shalaby

    Department of Medical Biophysics, Medical Research Institute, Alexandria University, Alexandria, Egypt

    Published Online:https://doi.org/10.2217/nnm-2023-0127

    Background: Impaired inflammation and vascularization are common reasons for delayed diabetic wound healing. Nanoparticles (NPs)-in-nanofibers composites can manage diabetic wounds. A multifunctional scaffold was developed based on tadalafil (TDF)-loaded NPs incorporated into polyvinyl alcohol/Withania somnifera extract nanofibers. Materials & methods: TDF-loaded NPs were prepared and fully characterized in terms of their physicochemical properties. Extract of ashwagandha was prepared and a blend composed of TDF-loaded NPs, herbal extract and polyvinyl alcohol was used to prepare the whole composite. Results: The whole composite exhibited improved wound closure in a diabetic rat model in terms of reduced inflammation and enhanced angiogenesis. Conclusion: Results suggest that this multifunctional composite could serve as a promising diabetic wound dressing.

    Graphical abstract

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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