Research Article

Antibacterial and anticancer activities of green-synthesized silver nanoparticles using Photinia glabra fruit extract

Department of Pharmaceutical Science & Technology, College of Biology & Medical Engineering, Donghua University, Shanghai, 201620, China

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Lei-Lei Bao

Dongfang Hepatobiliary Surgery Hospital, Shanghai, 200433, China

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Justus Kwetegyeka

Department of Chemistry, Faculty of Science, Kyambogo University, Kampala, Uganda

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Ivan Gumula

Department of Chemistry, Faculty of Science, Kyambogo University, Kampala, Uganda

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Yi-Jia Yan

*Author for correspondence:

E-mail Address: y_yan11@sina.com

Department of Pharmacy, Huadong Hospital, Fudan University, Shanghai, 200040, China

Shanghai Xianhui Pharmaceutical Co., Ltd, Shanghai, 201620, China

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Zhi-Long Chen

**Author for correspondence:

E-mail Address: zlchen1967@qq.com

Department of Pharmaceutical Science & Technology, College of Biology & Medical Engineering, Donghua University, Shanghai, 201620, China

Department of Pharmacy, Huadong Hospital, Fudan University, Shanghai, 200040, China

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Published Online:10 Aug 2023https://doi.org/10.2217/nnm-2023-0112

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Abstract

Aims: We prepared Photinia glabra (PG) aqueous fruit extract, utilized it to synthesize silver nanoparticles (PG-Ag NPs) and evaluated the antibacterial and anticancer activities of the nanoparticles (NPs). Materials & methods: Silver nitrate aqueous solution was reduced to PG-Ag NPs using aqueous PG fruit extract. NP shape, size, composition and functionalization were determined using transmission electron microscopy, x-ray photoelectron spectroscopy, Fourier transform infrared and x-ray diffraction. Results & conclusions: PG-Ag NPs were spherical, approximately 39–77 nm-sized, functionalized surfaces with notable antibacterial activity against both Escherichia coli and Staphylococcus aureus, with an MIC <30 ug/ml and cytotoxicity toward esophageal cancer cells, with IC₅₀ values less than 20 ug/ml. PG-Ag@rt NPs have been shown to be a potent antibacterial and anticancer agent, and their enriched particle surfaces can be conjugated with other compounds for multibiomedical applications.

Plain language summary

The present study reports for the first time the preparation of Photinia glabra (PG) aqueous fruit extract and its use for the synthesis of smaller silver particles (PG-Ag NPs) from bulk aqueous silver nitrate solution (AgNO₃). The preparation followed the reduction ability of PG fruit extract phytochemical under different preparation conditions: at room temperature (PG-Ag@rt), at 70°C (PG-Ag@70) and in the presence of cerium oxide at 70°C (PG-Ag+CeO₂@70). The prepared smaller particles were found using transmission electron microscopy to be spherical in shape with sizes 39, 77 and 44 nm for PG-Ag@rt, PG-Ag@70 and PG-Ag+CeO₂@70, respectively. The NPs contained different functional groups on their surfaces due to the capping ability of PG fruit extract components. Among all, PG-Ag@rt NPs showed strongest antibacterial activity against Escherichia coli and Staphylococcus aureus with MIC 7.0 μg/ml and 28.0 μg/ml, respectively, and commendable anticancer activity toward Eca-109 cancer cells with IC₅₀ less than 20 ug/ml.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 18, No. 14

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Received 20 April 2023

Accepted 6 July 2023

Published online 10 August 2023

Published in print June 2023

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To view the supplementary data that accompany this paper please visit the journal website at: www.futuremedicine.com/doi/suppl/10.2217/nnm-2023-0112

Author contributions

The manuscript was written and revised through contributions of all authors. All authors have read and agreed to the final version of the manuscript.

Financial & competing interests disclosure

This work was supported by the National Natural Science Foundation of China (no. 21977016), Foundation of Shanghai Science and Technology Committee (nos. 20430730900, 20490740400, 21430730100 and 23S11901600) and a grant from Dongfang Hepatobiliary Surgery Hospital (nos. 20WQ011 and 2019-539). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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