Recent progress in therapeutic strategies and biomimetic nanomedicines based on neutrophils for inflammation treatment

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1. He Y, Yue Y, Zheng X et al. Curcumin, inflammation, and chronic diseases: how are they linked? Molecules 20(5), 9183–9213 (2015).
  Medline CASGoogle Scholar
• 2. Zhang G, Ma L, Bai L et al. Inflammatory microenvironment-targeted nanotherapies. J. Control. Rel. 334, 114–126 (2021).
  Medline CASGoogle Scholar
• 3. Schraufstätter I, Hyslop PA, Jackson JH, Cochrane CG. Oxidant-induced DNA damage of target cells. J. Clin. Invest. 82(3), 1040–1050 (1988).
  Medline CASGoogle Scholar
• 4. Couzin-Frankel J. Inflammation bares a dark side. Science. 330(6011), 1621 (2010).
  Medline CASGoogle Scholar
• 5. Nasef NA, Mehta S, Ferguson LR. Susceptibility to chronic inflammation: an update. Arch. Toxicol. 91(3), 1131–1141 (2017).
  Medline CASGoogle Scholar
• 6. Straub RH. The brain and immune system prompt energy shortage in chronic inflammation and ageing. Nat. Rev. Rheumatol. 13(12), 743–751 (2017).
  Medline CASGoogle Scholar
• 7. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 140(6), 883–899 (2010).
  Medline CASGoogle Scholar
• 8. Haley RM, Von Recum HA. Localized and targeted delivery of NSAIDs for treatment of inflammation: a review. Exp. Biol. Med. 244(6), 433–444 (2019).
  CASGoogle Scholar
• 9. George MD, Baker JF, Winthrop K et al. Risk for serious infection with low-dose glucocorticoids in patients with rheumatoid arthritis: a cohort study. Ann. Intern. Med. 173(11), 870–878 (2020).
  MedlineGoogle Scholar
• 10. Sargazi S, Arshad R, Ghamari R et al. siRNA-based nanotherapeutics as emerging modalities for immune-mediated diseases: a preliminary review. Cell Biol. Int. 46(9), 1320–1344 (2022).
  Medline CASGoogle Scholar
• 11. Nooreen R, Nene S, Jain H et al. Polymer nanotherapeutics: a versatile platform for effective rheumatoid arthritis therapy. J. Control. Rel. 348, 397–419 (2022).
  Medline CASGoogle Scholar
• 12. Badri W, Miladi K, Nazari QA et al. Encapsulation of NSAIDs for inflammation management: overview, progress, challenges and prospects. Int. J. Pharm. 515(1-2), 757–773 (2016).
  Medline CASGoogle Scholar
• 13. Wang Q, Qin X, Fang J, Sun X. Nanomedicines for the treatment of rheumatoid arthritis: state of art and potential therapeutic strategies. Acta Pharm. Sinica. B 11(5), 1158–1174 (2021).
  MedlineGoogle Scholar
• 14. Simadibrata M. Gastrointestinal tract disorder as a side effect of non-steroidal anti inflammatory drugs (NSAIDs). Acta Med. Indonesiana 36(4), 195–196 (2004).
  MedlineGoogle Scholar
• 15. Li C, Zheng X, Hu M et al. Recent progress in therapeutic strategies and biomimetic nanomedicines for rheumatoid arthritis treatment. Expert Opin. Drug Deliv. 19(8), 883–898 (2022).
  Medline CASGoogle Scholar
• 16. Emerich DF. Nanomedicine–prospective therapeutic and diagnostic applications. Expert Opin. Biol. Ther. 5(1), 1–5 (2005).
  Medline CASGoogle Scholar
• 17. Grazú V. Nanocarriers as nanomedicines. Front. of Nanosci. 4, 337–440 (2012).
  Google Scholar
• 18. Kreuter J. Nanoparticles – a historical perspective. Int. J. Pharm. 331(1), 1–10 (2007).
  Medline CASGoogle Scholar
• 19. Jin K, Luo Z, Zhang B, Pang Z. Biomimetic nanoparticles for inflammation targeting. Acta Pharm. Sinica. B 8(1), 23–33 (2018).
  MedlineGoogle Scholar
• 20. Ejigah V, Owoseni O, Bataille-Backer P et al. Approaches to improve macromolecule and nanoparticle accumulation in the tumor microenvironment by the enhanced permeability and retention effect. Polymers 14(13), 2601(2022).
  Medline CASGoogle Scholar
• 21. Wang H, Liu Y, He R et al. Cell membrane biomimetic nanoparticles for inflammation and cancer targeting in drug delivery. Biomater. Sci. 8(2), 552–568 (2020).
  Medline CASGoogle Scholar
• 22. Wang H, Zang J, Zhao Z et al. The advances of neutrophil-derived effective drug delivery systems: a key review of managing tumors and inflammation. Int. J. Nanomed. 16, 7663–7681 (2021).
  Medline CASGoogle Scholar
• 23. Nemeth T, Sperandio M, Mocsai A. Neutrophils as emerging therapeutic targets. Nat. Rev. Drug Discov. 19(4), 253–275 (2020).
  Medline CASGoogle Scholar
• 24. Chu D, Dong X, Shi X et al. Neutrophil-based drug delivery systems. Adv. Mater. 30(22), e1706245 (2018).
  MedlineGoogle Scholar
• 25. Rosales C. Neutrophils at the crossroads of innate and adaptive immunity. J. Leukoc. Biol. 108(1), 377–396 (2020).
  Medline CASGoogle Scholar
• 26. Wang W, Zhang Z, Liu Y et al. Nano-integrated cascade antioxidases opsonized by albumin bypass the blood-brain barrier for treatment of ischemia-reperfusion injury. Biomater. Sci. 10(24), 7103–7116 (2022). •• The ability of neutrophils to cross the blood–brain barrier was used to deliver albumin drug-carrying nanoparticles via neutrophils to the disease site.
  Medline CASGoogle Scholar
• 27. Carnevale S, Ghasemi S, Rigatelli A, Jaillon S. The complexity of neutrophils in health and disease: focus on cancer. Semin. Immunol. 48, 101409 (2020).
  Medline CASGoogle Scholar
• 28. Smith JA. Neutrophils, host defense, and inflammation: a double-edged sword. J. Leuk. Biol. 56(6), 672–686 (1994).
  Medline CASGoogle Scholar
• 29. Laudanna C, Alon R. Right on the spot. Chemokine triggering of integrin-mediated arrest of rolling leukocytes. Thromb. Haemostas. 95(1), 5–11 (2006).
  Medline CASGoogle Scholar
• 30. Phillipson M, Heit B, Colarusso P et al. Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J. Exp. Med. 203(12), 2569–2575 (2006).
  Medline CASGoogle Scholar
• 31. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat. Rev. Immunol. 7(9), 678–689 (2007).
  Medline CASGoogle Scholar
• 32. Liew PX, Kubes P. The neutrophil's role during health and disease. Physiol. Rev. 99(2), 1223–1248 (2019).
  Medline CASGoogle Scholar
• 33. Fournier BM, Parkos CA. The role of neutrophils during intestinal inflammation. Mucosal Immunol. 5(4), 354–366 (2012).
  Medline CASGoogle Scholar
• 34. Tecchio C, Micheletti A, Cassatella MA. Neutrophil-derived cytokines: facts beyond expression. Front. Immunol. 5, 508 (2014).
  MedlineGoogle Scholar
• 35. Huang SU, O'Sullivan KM. The expanding role of extracellular traps in inflammation and autoimmunity: the new players in casting dark webs. Int. J. Mol. Sci. 23(7), 3793 (2022).
  Medline CASGoogle Scholar
• 36. Campbell EL, Kao DJ, Colgan SP. Neutrophils and the inflammatory tissue microenvironment in the mucosa. Immunol. Rev. 273(1), 112–120 (2016).
  Medline CASGoogle Scholar
• 37. Delgado-Rizo V, Martínez-Guzmán MA, Iñiguez-Gutierrez L et al. Neutrophil extracellular traps and its implications in inflammation: an overview. Front. Immunol. 8, 81 (2017).
  MedlineGoogle Scholar
• 38. Thiam HR, Wong SL, Wagner DD, Waterman CM. Cellular mechanisms of NETosis. Annu. Rev. Cell Dev. Biol. 36, 191–218 (2020).
  Medline CASGoogle Scholar
• 39. Papayannopoulos V, Metzler KD, Hakkim A, Zychlinsky A. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J. Cell Biol. 191(3), 677–691 (2010).
  Medline CASGoogle Scholar
• 40. Sollberger G, Tilley DO, Zychlinsky A. Neutrophil extracellular traps: the biology of chromatin externalization. Dev. Cell 44(5), 542–553 (2018).
  Medline CASGoogle Scholar
• 41. Fidan K, Koçak S, Söylemezoğlu O, Atak Yücel A. A well-intentioned enemy in autoimmune and autoinflammatory diseases: NETosis. Turk Arch. Pediatr. 58(1), 10–19 (2023). • This review details the role of NETosis in autoimmune and autoinflammatory diseases.
  MedlineGoogle Scholar
• 42. Castanheira FVS, Kubes P. Neutrophils and NETs in modulating acute and chronic inflammation. Blood 133(20), 2178–2185 (2019).
  Medline CASGoogle Scholar
• 43. Bissenova S, Ellis D, Mathieu C, Gysemans C. Neutrophils in autoimmunity: when the hero becomes the villain. Clin. Exp. Immunol. 210(2), 128–140 (2022).
  MedlineGoogle Scholar
• 44. Zhao Z, Pan Z, Zhang S et al. Neutrophil extracellular traps: a novel target for the treatment of stroke. Pharmacol. Ther. 241, 108328 (2023).
  Medline CASGoogle Scholar
• 45. Tembhre MK, Sriwastva MK, Hote MP et al. Interleukin-33 induces neutrophil extracellular trap (NET) formation and macrophage necroptosis via enhancing oxidative stress and secretion of proatherogenic factors in advanced atherosclerosis. Antioxidants (Basel) 11(12), 2343 (2022).
  Medline CASGoogle Scholar
• 46. Cacciotto C, Alberti A. Eating the enemy: mycoplasma strategies to evade neutrophil extracellular traps (NETs) promoting bacterial nucleotides uptake and inflammatory damage. Int. J. Mol. Sci. 23(23), 15030 (2022).
  Medline CASGoogle Scholar
• 47. Pan W, Xin Q, Xu J et al. IgD enhances the release of neutrophil extracellular traps (NETs) via FcδR in rheumatoid arthritis patients. Int. Immunopharmacol. 114, 109484 (2023).
  Medline CASGoogle Scholar
• 48. Albrengues J, Shields MA, Ng D et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 361(6409), eaao4227 (2018).
  MedlineGoogle Scholar
• 49. Aikawa N, Kawasaki Y. Clinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome. Ther. Clin. Risk Manage. 10, 621–629 (2014).
  Medline CASGoogle Scholar
• 50. Zeiher BG, Artigas A, Vincent JL et al. Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit. Care Med. 32(8), 1695–1702 (2004).
  Medline CASGoogle Scholar
• 51. Sahebnasagh A, Saghafi F, Safdari M et al. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J. Clin. Pharm. Ther. 45(6), 1515–1519 (2020).
  Medline CASGoogle Scholar
• 52. Okeke EB, Louttit C, Fry C et al. Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock. Biomaterials 238, 119836 (2020).
  Medline CASGoogle Scholar
• 53. Dong W, Liu D, Zhang T et al. Oral delivery of staphylococcal nuclease ameliorates DSS induced ulcerative colitis in mice via degrading intestinal neutrophil extracellular traps. Ecotoxicol. Environ. Safety 215, 112161 (2021).
  Medline CASGoogle Scholar
• 54. Kim JY, Stevens P, Karpurapu M et al. Targeting ETosis by miR-155 inhibition mitigates mixed granulocytic asthmatic lung inflammation. Front. Immunol. 13, 943554 (2022). • The production of ETosis was inhibited by lowering the expression of miR-155, thus alleviating pneumonia.
  Medline CASGoogle Scholar
• 55. Özcan A, Boyman O. Mechanisms regulating neutrophil responses in immunity, allergy, and autoimmunity. Allergy 77(12), 3567–3583 (2022).
  Medline CASGoogle Scholar
• 56. Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat. Rev. Immunol. 13(3), 159–175 (2013).
  Medline CASGoogle Scholar
• 57. Van Der Linden M, Meyaard L. Fine-tuning neutrophil activation: strategies and consequences. Immunol. Lett. 178, 3–9 (2016).
  MedlineGoogle Scholar
• 58. Bayless RL, Sheats MK, Jones SL. Withaferin A inhibits neutrophil adhesion, migration, and respiratory burst and promotes timely neutrophil apoptosis. Front. Vet. Sci. 9, 900453 (2022).
  MedlineGoogle Scholar
• 59. Basu S, Hodgson G, Katz M, Dunn AR. Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation. Blood 100(3), 854–861 (2002).
  Medline CASGoogle Scholar
• 60. Kobayashi SD, Voyich JM, Whitney AR, Deleo FR. Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor. J. Leukocyte Biol. 78(6), 1408–1418 (2005).
  Medline CASGoogle Scholar
• 61. Ioannou M, Hoving D, Aramburu IV et al. Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening. Nat. Commun. 13(1), 4658 (2022).
  Medline CASGoogle Scholar
• 62. Hou M, Wu X, Zhao Z et al. Endothelial cell-targeting, ROS-ultrasensitive drug/siRNA co-delivery nanocomplexes mitigate early-stage neutrophil recruitment for the anti-inflammatory treatment of myocardial ischemia reperfusion injury. Acta Biomater. 143, 344–355 (2022).
  Medline CASGoogle Scholar
• 63. Kobayashi SD, Voyich JM, Braughton KR, Deleo FR. Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes. J. Immunol. 170(6), 3357–3368 (2003).
  Medline CASGoogle Scholar
• 64. Barone A, D'avanzo N, Cristiano MC et al. Macrophage-derived extracellular vesicles: a promising tool for personalized cancer therapy. Biomedicines 10(6), 1252 (2022).
  Medline CASGoogle Scholar
• 65. Zhang CY, Dong X, Gao J et al. Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke. Sci. Adv. 5(11), eaax7964 (2019).
  Medline CASGoogle Scholar
• 66. Kala SG, Chinni S. Development and characterization of venetoclax nanocrystals for oral bioavailability enhancement. AAPS PharmSciTech 22(3), 92 (2021).
  Medline CASGoogle Scholar
• 67. Su R, Wang H, Xiao C et al. Venetoclax nanomedicine alleviates acute lung injury via increasing neutrophil apoptosis. Biomater. Sci. 9(13), 4746–4754 (2021). • Venetoclax nanodrug was used to reduce acute lung injury by increasing neutrophil apoptosis.
  Medline CASGoogle Scholar
• 68. Shi J, Li J. Neutrophil-targeted engineered prodrug nanoparticles for anti-inflammation. FASEB J 34(8), 9828–9831 (2020).
  Medline CASGoogle Scholar
• 69. Eyles JL, Hickey MJ, Norman MU et al. A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis. Blood 112(13), 5193–5201 (2008).
  Medline CASGoogle Scholar
• 70. Kruger P, Saffarzadeh M, Weber AN et al. Neutrophils: between host defence, immune modulation, and tissue injury. PLOS Pathogens 11(3), e1004651 (2015).
  MedlineGoogle Scholar
• 71. Brennan FM, Zachariae CO, Chantry D et al. Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells. Eur. J. Immunol. 20(9), 2141–2144 (1990).
  Medline CASGoogle Scholar
• 72. Emmi G, Becatti M, Bettiol A et al. Behcet's syndrome as a model of thrombo-inflammation: the role of neutrophils. Front. Immunol. 10, 1085 (2019).
  Medline CASGoogle Scholar
• 73. O'Neil LJ, Kaplan MJ. Neutrophils in rheumatoid arthritis: breaking immune tolerance and fueling disease. Trends Mol. Med. 25(3), 215–227 (2019).
  MedlineGoogle Scholar
• 74. Gajbhiye KR, Gajbhiye V, Siddiqui IA, Gajbhiye JM. cRGD functionalised nanocarriers for targeted delivery of bioactives. J. Drug Target. 27(2), 111–124 (2019).
  Medline CASGoogle Scholar
• 75. Sadik CD, Kim ND, Iwakura Y, Luster AD. Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling. Proc. Natl. Acad. Sci. USA 109(46), E3177–E3185 (2012).
  Medline CASGoogle Scholar
• 76. Wang Z, Li J, Cho J, Malik AB. Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils. Nat. Nanotechnol. 9(3), 204–210 (2014).
  Medline CASGoogle Scholar
• 77. Chu D, Gao J, Wang Z. Neutrophil-mediated delivery of therapeutic nanoparticles across blood vessel barrier for treatment of inflammation and infection. ACS Nano 9(12), 11800–11811 (2015).
  Medline CASGoogle Scholar
• 78. Lyu J, Wang L, Bai X et al. Treatment of rheumatoid arthritis by serum albumin nanoparticles coated with mannose to target neutrophils. ACS Appl. Mater. Interfaces 13(1), 266–276 (2021).
  Medline CASGoogle Scholar
• 79. Fan C, Li C, Lu S et al. Polysialic acid self-assembled nanocomplexes for neutrophil-based immunotherapy to suppress lung metastasis of breast cancer. AAPS PharmSciTech 23(4), 109 (2022).
  Medline CASGoogle Scholar
• 80. Raffler NA, Rivera-Nieves J, Ley K. L-selectin in inflammation, infection and immunity. Drug Discov. Today Ther. Strat. 2(3), 213–220 (2005).
  Google Scholar
• 81. Hu L, Luo X, Zhou S et al. Neutrophil-mediated delivery of dexamethasone palmitate-loaded liposomes decorated with a sialic acid conjugate for rheumatoid arthritis treatment. Pharm. Res. 36(7), 97 (2019).
  MedlineGoogle Scholar
• 82. Haroon HB, Hunter AC, Farhangrazi ZS, Moghimi SM. A brief history of long circulating nanoparticles. Adv. Drug Deliv. Rev. 188, 114396 (2022).
  Medline CASGoogle Scholar
• 83. Luk BT, Zhang L. Cell membrane-camouflaged nanoparticles for drug delivery. J. Control. Rel. 220(Pt B), 600–607 (2015).
  Medline CASGoogle Scholar
• 84. Yurkin ST, Wang Z. Cell membrane-derived nanoparticles: emerging clinical opportunities for targeted drug delivery. Nanomedicine 12(16), 2007–2019 (2017).
  CASGoogle Scholar
• 85. Rampado R, Biccari A, D'Angelo E et al. Optimization of biomimetic, leukocyte-mimicking nanovesicles for drug delivery against colorectal cancer using a design of experiment approach. Front. Bioeng. Biotechnol. 10, 883034 (2022).
  MedlineGoogle Scholar
• 86. Matsuzaka Y, Yashiro R. Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine. Int. J. Mol. Sci. 23(12), 6480(2022).
  Medline CASGoogle Scholar
• 87. Dostalova S, Vasickova K, Hynek D et al. Apoferritin as an ubiquitous nanocarrier with excellent shelf life. Int. J. Nanomed. 12, 2265–2278 (2017).
  Medline CASGoogle Scholar
• 88. Veroniaina H, Pan X, Wu Z, Qi X. Apoferritin: a potential nanocarrier for cancer imaging and drug delivery. Expert Rev. Anticancer Ther. 21(8), 901–913 (2021).
  Medline CASGoogle Scholar
• 89. Xue J, Zhao Z, Zhang L et al. Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence. Nat. Nanotechnol. 12(7), 692–700 (2017).
  Medline CASGoogle Scholar
• 90. Wu M, Zhang H, Tie C et al. MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma. Nat. Commun. 9(1), 4777 (2018).
  MedlineGoogle Scholar
• 91. Ju C, Wen Y, Zhang L et al. Neoadjuvant chemotherapy based on abraxane/human neutrophils cytopharmaceuticals with radiotherapy for gastric cancer. Small 15(5), e1804191 (2019).
  MedlineGoogle Scholar
• 92. Ye B, Zhao B, Wang K et al. Neutrophils mediated multistage nanoparticle delivery for prompting tumor photothermal therapy. J. Nanobiotechnol. 18(1), 138 (2020).
  Medline CASGoogle Scholar
• 93. Sun R, Wang X, Nie Y et al. Targeted trapping of endogenous endothelial progenitor cells for myocardial ischemic injury repair through neutrophil-mediated SPIO nanoparticle-conjugated CD34 antibody delivery and imaging. Acta Biomater. 146, 421–433 (2022).
  Medline CASGoogle Scholar
• 94. Kang T, Zhu Q, Wei D et al. Nanoparticles coated with neutrophil membranes can effectively treat cancer metastasis. ACS Nano 11(2), 1397–1411 (2017).
  Medline CASGoogle Scholar
• 95. Zhang Q, Dehaini D, Zhang Y et al. Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis. Nat. Nanotechnol. 13(12), 1182–1190 (2018).
  Medline CASGoogle Scholar
• 96. Zhou X, Cao X, Tu H et al. Inflammation-targeted delivery of celastrol via neutrophil membrane-coated nanoparticles in the management of acute pancreatitis. Mol. Pharm. 16(3), 1397–1405 (2019).
  Medline CASGoogle Scholar
• 97. Liu Z, Liu X, Yang Q et al. Neutrophil membrane-enveloped nanoparticles for the amelioration of renal ischemia-reperfusion injury in mice. Acta Biomater. 104, 158–166 (2020).
  Medline CASGoogle Scholar
• 98. Zhang Z, Li D, Cao Y et al. Biodegradable hypocrellin B nanoparticles coated with neutrophil membranes for hepatocellular carcinoma photodynamics therapy effectively via JUNB/ROS signaling. Int. Immunopharmacol. 99, 107624 (2021).
  Medline CASGoogle Scholar
• 99. Hassanzadeh P, Arbabi E, Rostami F. Coating of ferulic acid-loaded silk fibroin nanoparticles with neutrophil membranes: a promising strategy against the acute pancreatitis. Life Sci. 270, 119128 (2021).
  Medline CASGoogle Scholar
• 100. Xie W, Liu P, Gao F et al. Platelet-neutrophil hybrid membrane-coated gelatin nanoparticles for enhanced targeting ability and intelligent release in the treatment of non-alcoholic steatohepatitis. Nanomed. Nanotechnol. Biol. Med. 42, 102538 (2022). •• The authors used a platelet–neutrophil mixed membrane coated with gelatin nanoparticles to enhance hepatitis targeting and intelligent release function.
  CASGoogle Scholar
• 101. Gao J, Chu D, Wang Z. Cell membrane-formed nanovesicles for disease-targeted delivery. J. Control. Rel. 224, 208–216 (2016).
  Medline CASGoogle Scholar
• 102. Gao J, Wang S, Wang Z. High yield, scalable and remotely drug-loaded neutrophil-derived extracellular vesicles (EVs) for anti-inflammation therapy. Biomaterials 135, 62–73 (2017).
  Medline CASGoogle Scholar
• 103. Dong X, Gao J, Zhang CY et al. Neutrophil membrane-derived nanovesicles alleviate inflammation to protect mouse brain injury from ischemic stroke. ACS Nano 13(2), 1272–1283 (2019).
  Medline CASGoogle Scholar
• 104. Gao J, Dong X, Su Y, Wang Z. Human neutrophil membrane-derived nanovesicles as a drug delivery platform for improved therapy of infectious diseases. Acta Biomaterialia 123, 354–363 (2021).
  Medline CASGoogle Scholar
• 105. Wang J, Tang W, Yang M et al. Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy. Biomaterials 273, 120784 (2021).
  Medline CASGoogle Scholar
• 106. Zhang J, Ji C, Zhang H et al. Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy. Sci. Adv. 8(2), eabj8207 (2022).
  Medline CASGoogle Scholar
• 107. Zhang L, Qin Z, Sun H et al. Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment. Bioact. Mater. 18, 1–14 (2022). •• The authors used the inflammatory chemotaxis and anti-inflammatory capabilities of neutrophil-derived EVs to prepare drug-loaded nanoparticles.
  MedlineGoogle Scholar
• 108. Ishida T, Atobe K, Wang X, Kiwada H. Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection. J. Control. Rel. 115(3), 251–258 (2006).
  Medline CASGoogle Scholar
• 109. Ishida T, Ichihara M, Wang X et al. Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J. Control. Rel. 112(1), 15–25 (2006).
  Medline CASGoogle Scholar
• 110. Wang D, Wang S, Zhou Z et al. White blood cell membrane-coated nanoparticles: recent development and medical applications. Adv. Healthc. Mater. 11(7), e2101349 (2022).
  Medline CASGoogle Scholar
• 111. Larsen C, Ostergaard J, Larsen SW et al. Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders. J. Pharm. Sci. 97(11), 4622–4654 (2008).
  Medline CASGoogle Scholar
• 112. Simón-Vázquez R, Tsapis N, Lorscheider M et al. Improving dexamethasone drug loading and efficacy in treating arthritis through a lipophilic prodrug entrapped into PLGA-PEG nanoparticles. Drug Deliv. Transl. Res. 12(5), 1270–1284 (2022).
  Medline CASGoogle Scholar
• 113. Chen Y, Wu Q, Zhang Z et al. Preparation of curcumin-loaded liposomes and evaluation of their skin permeation and pharmacodynamics. Molecules 17(5), 5972–5987 (2012).
  Medline CASGoogle Scholar
• 114. Liu X, Zhang L, Jiang W et al. In vitro and in vivo evaluation of liposomes modified with polypeptides and red cell membrane as a novel drug delivery system for myocardium targeting. Drug Deliv. 27(1), 599–606 (2020).
  Medline CASGoogle Scholar
• 115. Liu P, Gu L, Ren L et al. Intra-articular injection of etoricoxib-loaded PLGA-PEG-PLGA triblock copolymeric nanoparticles attenuates osteoarthritis progression. Am. J. Transl. Res. 11(11), 6775–6789 (2019).
  Medline CASGoogle Scholar
• 116. Dong J, Jiang D, Wang Z et al. Intra-articular delivery of liposomal celecoxib-hyaluronate combination for the treatment of osteoarthritis in rabbit model. Int. J. Pharm. 441(1-2), 285–290 (2013).
  Medline CASGoogle Scholar
• 117. Casares D, Escribá PV, Rosselló CA. Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues. Int. J. Mol. Sci. 20(9), (2019).
  MedlineGoogle Scholar
• 118. Liang T, Zhang R, Liu X et al. Recent advances in macrophage-mediated drug delivery systems. Int. J. Nanomed. 16, 2703–2714 (2021).
  MedlineGoogle Scholar
• 119. Rauchhaus U, Schwaiger FW, Panzner S. Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment. Arthritis Res. Ther. 11(6), R190 (2009).
  MedlineGoogle Scholar
• 120. Song G, Petschauer JS, Madden AJ, Zamboni WC. Nanoparticles and the mononuclear phagocyte system: pharmacokinetics and applications for inflammatory diseases. Curr. Rheumatol. Rev. 10(1), 22–34 (2014).
  Medline CASGoogle Scholar
• 121. Li SD, Huang L. Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharm. 5(4), 496–504 (2008).
  Medline CASGoogle Scholar
• 122. Mirkasymov AB, Zelepukin IV, Nikitin PI et al. In vivo blockade of mononuclear phagocyte system with solid nanoparticles: efficiency and affecting factors. J. Control. Rel. 330, 111–118 (2021).
  Medline CASGoogle Scholar
• 123. Wang K, Lei Y, Xia D et al. Neutrophil membranes coated, antibiotic agent loaded nanoparticles targeting to the lung inflammation. Colloids and Surfaces. B Biointerfaces 188, 110755 (2020).
  Medline CASGoogle Scholar
• 124. Li W, Su Z, Hao M, Ju C, Zhang C. Cytopharmaceuticals: an emerging paradigm for drug delivery. J. Control. Rel. 328, 313–324 (2020).
  Medline CASGoogle Scholar
• 125. Neog MK, Rasool M. Targeted delivery of p-coumaric acid encapsulated mannosylated liposomes to the synovial macrophages inhibits osteoclast formation and bone resorption in the rheumatoid arthritis animal model. Eur. J. Pharm. Biopharm. 133, 162–175 (2018).
  Medline CASGoogle Scholar
• 126. Vijayan V, Uthaman S, Park IK. Cell membrane coated nanoparticles: an emerging biomimetic nanoplatform for targeted bioimaging and therapy. Adv. Exp. Med. Biol. 1064, 45–59 (2018).
  Medline CASGoogle Scholar
• 127. Godfrin Y, Horand F, Franco R et al. International seminar on the red blood cells as vehicles for drugs. Exp. Opin. Biol. Ther. 12(1), 127–133 (2012).
  MedlineGoogle Scholar
• 128. Xu P, Zuo H, Zhou R et al. Doxorubicin-loaded platelets conjugated with anti-CD22 mAbs: a novel targeted delivery system for lymphoma treatment with cardiopulmonary avoidance. Oncotarget 8(35), 58322–58337 (2017).
  MedlineGoogle Scholar
• 129. Stuckey DW, Shah K. Stem cell-based therapies for cancer treatment: separating hope from hype. Nat. Rev. Cancer 14(10), 683–691 (2014).
  Medline CASGoogle Scholar
• 130. Li Z, Huang H, Tang S et al. Small gold nanorods laden macrophages for enhanced tumor coverage in photothermal therapy. Biomaterials 74, 144–154 (2016).
  Medline CASGoogle Scholar
• 131. Ma Q, Cao J, Gao Y et al. Microfluidic-mediated nano-drug delivery systems: from fundamentals to fabrication for advanced therapeutic applications. Nanoscale 12(29), 15512–15527 (2020).
  Medline CASGoogle Scholar
• 132. Su Y, Xie Z, Kim GB et al. Design strategies and applications of circulating cell-mediated drug delivery systems. ACS Biomater. Sci. Eng. 1(4), 201–217 (2015).
  Medline CASGoogle Scholar
• 133. Yu H, Yang Z, Li F et al. Cell-mediated targeting drugs delivery systems. Drug Deliv. 27(1), 1425–1437 (2020).
  Medline CASGoogle Scholar
• 134. Kaltenmeier C, Yazdani HO, Handu S et al. The role of neutrophils as a driver in hepatic ischemia-reperfusion injury and cancer growth. Front. Immunol. 13, 887565 (2022).
  Medline CASGoogle Scholar
• 135. Gao J, Hu X, Xu C et al. Neutrophil-mediated delivery of the combination of colistin and azithromycin for the treatment of bacterial infection. iScience 25(9), 105035 (2022).
  Medline CASGoogle Scholar
• 136. Salvermoser M, Begandt D, Alon R, Walzog B. Nuclear deformation during neutrophil migration at sites of inflammation. Front. Immunol. 9, 2680 (2018).
  MedlineGoogle Scholar
• 137. Pick R, Brechtefeld D, Walzog B. Intraluminal crawling versus interstitial neutrophil migration during inflammation. Mol. Immunol. 55(1), 70–75 (2013).
  Medline CASGoogle Scholar
• 138. Yuan H, Li J, Bao G, Zhang S. Variable nanoparticle-cell adhesion strength regulates cellular uptake. Phys. Rev. Lett. 105(13), 138101 (2010).
  MedlineGoogle Scholar
• 139. Pillay J, Den Braber I, Vrisekoop N et al. In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days. Blood 116(4), 625–627 (2010).
  Medline CASGoogle Scholar
• 140. Chen J, Song Y, Wang Q et al. Targeted neutrophil-mimetic liposomes promote cardiac repair by adsorbing proinflammatory cytokines and regulating the immune microenvironment. J. Nanobiotechnol. 20(1), 218 (2022).
  Medline CASGoogle Scholar
• 141. Liu S, Xu J, Liu Y et al. Neutrophil-biomimetic ‘nanobuffer’ for remodeling the microenvironment in the infarct core and protecting neurons in the penumbra via neutralization of detrimental factors to treat ischemic stroke. ACS Appl. Mater. Interfaces 14(24), 27743–27761 (2022).
  Medline CASGoogle Scholar
• 142. Yang Y, Wang K, Pan Y et al. Engineered cell membrane-derived nanoparticles in immune modulation. Adv. Sci. 8(24), e2102330 (2021).
  Google Scholar
• 143. Wu Z, Zhang H, Yan J et al. Engineered biomembrane-derived nanoparticles for nanoscale theranostics. Theranostics 13(1), 20–39 (2023).
  MedlineGoogle Scholar
• 144. Chen T, Li Y, Sun R et al. Receptor-mediated NETosis on neutrophils. Front. Immunol. 12, 775267 (2021).
  Medline CASGoogle Scholar
• 145. Nie M, Yang L, Bi X et al. Neutrophil extracellular traps induced by IL8 promote diffuse large b-cell lymphoma progression via the TLR9 signaling. Clin. Cancer Res. 25(6), 1867–1879 (2019).
  Medline CASGoogle Scholar
• 146. Yáñez-Mó M, Siljander PR, Andreu Z et al. Biological properties of extracellular vesicles and their physiological functions. J. Extracell. Vesicles 4, 27066 (2015).
  MedlineGoogle Scholar
• 147. Lu M, Xing H, Yang Z et al. Recent advances on extracellular vesicles in therapeutic delivery: challenges, solutions, and opportunities. Eur. J. Pharm. Biopharm. 119, 381–395 (2017).
  Medline CASGoogle Scholar
• 148. Lu S, Wang R, Fu W, Si Y. Applications of extracellular vesicles in abdominal aortic aneurysm. Front. Cardiovasc. Med. 9, 927542 (2022).
  Medline CASGoogle Scholar
• 149. Pfister H. Neutrophil extracellular traps and neutrophil-derived extracellular vesicles: common players in neutrophil effector functions. Diagnostics 12(7), 1715 (2022).
  Medline CASGoogle Scholar
• 150. Bie N, Yong T, Wei Z et al. Extracellular vesicles for improved tumor accumulation and penetration. Adv. Drug Deliv. Rev. 188, 114450 (2022).
  Medline CASGoogle Scholar
• 151. Rezaie J, Nejati V, Mahmoodi M, Ahmadi M. Mesenchymal stem cells derived extracellular vesicles: a promising nanomedicine for drug delivery system. Biochem. Pharmacol. 203, 115167 (2022).
  Medline CASGoogle Scholar