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Research Article

Tumor vascular heterogeneity and the impact of subtumoral nanoemulsion biodistribution

    Jaqueline Vaz de Oliveira

    Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil

    ,
    Márcia Cristina Oliveira da Rocha

    Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil

    ,
    Ailton Antônio de Sousa-Junior

    Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil

    ,
    Mosar Corrêa Rodrigues

    Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil

    ,
    Gabriel Ribeiro Farias

    Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil

    ,
    Patrícia Bento da Silva

    Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil

    ,
    Sônia Nair Bao

    Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil

    ,
    Andris Figueiroa Bakuzis

    Institute of Physics, Federal University of Goiás, Goiânia, GO, 74690-900, Brazil

    ,
    Ricardo Bentes Azevedo

    Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil

    ,
    Paulo César Morais

    Institute of Physics, University of Brasília, Brasília, DF, 70910-900, Brazil

    Biotechnology & Genomic Sciences, Catholic University of Brasília, Brasília, DF, 70790-160, Brazil

    ,
    Luís Alexandre Muehlmann

    Faculty of Ceilândia, University of Brasília, Brasília, DF, 72220-900, Brazil

    &
    João Paulo Figueiró Longo

    *Author for correspondence: Tel.: +55 613 107 3087;

    E-mail Address: jplongo82@gmail.com

    Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil

    Published Online:https://doi.org/10.2217/nnm-2022-0176

    Aim: Investigate the heterogeneous tumor tissue organization and examine how this condition can interfere with the passive delivery of a lipid nanoemulsion in two breast cancer preclinical models (4T1 and Ehrlich). Materials & methods: The authors used in vivo image techniques to follow the nanoemulsion biodistribution and microtomography, as well as traditional histopathology and electron microscopy to evaluate the tumor structural characteristics. Results & conclusion: Lipid nanoemulsion was delivered to the tumor, vascular organization depends upon the subtumoral localization and this heterogeneous organization promotes a nanoemulsion biodistribution to the highly vascular peripherical region. Also, the results are presented with a comprehensive mathematical model, describing the differential biodistribution in two different breast cancer models, the 4T1 and Ehrlich models.

    Graphical abstract

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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