Research Article

Smart nanostructures for targeted oxygen-producing photodynamic therapy of skin photoaging and potential mechanism

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

Department of Dermatology, the Affiliated Huai’an Hospital of Xuzhou Medical University, the Second People’s Hospital of Huai’an, Huai’an, 223002, China

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Zhaopeng Lu

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

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Yuqi Huang

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

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Wenyu Jia

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

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Wandong Wang

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

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Xin Zhang

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

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Cheng Chen

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

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Yizhi Li

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

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Chunsheng Yang

Department of Dermatology, the Affiliated Huai’an Hospital of Xuzhou Medical University, the Second People’s Hospital of Huai’an, Huai’an, 223002, China

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Guan Jiang

*Author for correspondence:

E-mail Address: dr.guanjiang@gmail.com

https://orcid.org/0000-0001-9641-1207

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

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Published Online:26 Apr 2023https://doi.org/10.2217/nnm-2022-0170

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Abstract

Background: Photodynamic therapy increases collagen and decreases solar fibrosis in photoaged skin; however, the efficacy of photodynamic therapy is limited in tissues with a hypoxic microenvironment. Methods: A novel autogenous oxygen-targeted nanoparticle, named MCZT, was synthesized based on the zeolitic imidazole framework material ZIF-8, methyl aminolevulinate, catalase and an anti-TRPV1 monoclonal antibody, and its effects on skin photoaging were investigated. Results: MCZT was successfully synthesized and showed uniform particle size, good dispersion, and excellent biocompatibility and safety. Moreover, MCZT effectively alleviated UV-induced inflammation, cellular senescence and apoptosis in HFF-1 cells. In in vivo models, MCZT ameliorated UV-evoked erythema and wrinkling, inflammation and oxidative stress, as well as the loss of collagen fibers and water, in the skin of mice. Conclusion: These findings suggest that MCZT holds promising potential for the treatment of skin photoaging.

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Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 18, No. 3

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History

Received 7 July 2022

Accepted 28 February 2023

Published online 26 April 2023

Published in print February 2023

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Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.futuremedicine.com/doi/suppl/10.2217/nnm-2022-0170

Financial & competing interests disclosure

This study was funded by the National Natural Science Foundation of China Project (grant nos. 81572976, 81872493, 81803151), the Key University Science Research Project of Jiangsu Province (grant no. KYCX20_2495), the College Students’ Innovation Entrepreneurial Training Plan Program (no. 202010313011Z), Science and Technology Development Fund project of Affiliated Hospital of Xuzhou Medical University (grant no. XYFY202245), the ‘Six Talent Peaks’ Project of Jiangsu Province (grant nos. WSN-254) and National Demonstration Center for Experiment Education of Basic Medical Sciences (Xuzhou Medical University, 221002, China). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

Experiments on animals were conducted according to the guidelines of EU Directive 2010/63/E and approved by the Laboratory Animal Ethics Committee of the Xuzhou Medical University, Xuzhou 221002, China.

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