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Molecular insights and therapeutic implications of nanoengineered dietary polyphenols for targeting lung carcinoma: part I

    Sabya Sachi Das

    Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India

    School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun, Uttarakhand, 248009, India

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Srushti Tambe

    Department of Pharmaceutical Science and Technology, Institute of Chemical Technology, Mumbai, Maharashtra, 400019, India

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Priya Ranjan Prasad Verma

    Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India

    ,
    Purnima Amin

    Department of Pharmaceutical Science and Technology, Institute of Chemical Technology, Mumbai, Maharashtra, 400019, India

    ,
    Neeru Singh

    Department of Biomedical Laboratory Technology, University Polytechnic, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India

    ,
    Sandeep Kumar Singh

    *Author for correspondence:

    E-mail Address: sandeep.singh@bitmesra.ac.in

    Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India

    &
    Piyush Kumar Gupta

    ** Author for correspondence:

    E-mail Address: dr.piyushkgupta@gmail.com

    Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, 201310, India

    Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, Uttarakhand, 248002, India

    Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia

    Published Online:https://doi.org/10.2217/nnm-2022-0133

    Lung cancer is the second leading cause of cancer-related mortality globally, and non-small-cell lung cancer accounts for most lung cancer cases. Nanotechnology-based drug-delivery systems have exhibited immense potential in lung cancer therapy due to their fascinating physicochemical characteristics, in vivo stability, bioavailability, prolonged and targeted delivery, gastrointestinal absorption and therapeutic efficiency of their numerous chemotherapeutic agents. However, traditional chemotherapeutics have systemic toxicity issues; therefore, dietary polyphenols might potentially replace them in lung cancer treatment. Polyphenol-based targeted nanotherapeutics have demonstrated interaction with a multitude of protein targets and cellular signaling pathways that affect major cellular processes. This review summarizes the various molecular mechanisms and targeted therapeutic potentials of nanoengineered dietary polyphenols in the effective management of lung cancer.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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