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Molecular insights and therapeutic implications of nanoengineered dietary polyphenols for targeting lung cancer: part II

    Sabya Sachi Das

    Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India

    School of Pharmaceutical & Population Health Informatics, DIT University, Dehradun, Uttarakhand, 248009, India

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Srushti Tambe

    Department of Pharmaceutical Science & Technology, Institute of Chemical Technology, Mumbai, Maharashtra, 400019, India

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Priya Ranjan Prasad Verma

    Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India

    ,
    Purnima Amin

    Department of Pharmaceutical Science & Technology, Institute of Chemical Technology, Mumbai, Maharashtra, 400019, India

    ,
    Neeru Singh

    Department of Biomedical Laboratory Technology, University Polytechnic, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India

    ,
    Sandeep Kumar Singh

    *Author for correspondence:

    E-mail Address: sandeep.singh@bitmesra.ac.in

    Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India

    &
    Piyush Kumar Gupta

    **Author for correspondence:

    E-mail Address: dr.piyushkgupta@gmail.com

    Department of Life Sciences, Sharda School of Basic Sciences & Research, Sharda University, Greater Noida, Uttar Pradesh, 201310, India

    Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, Uttarakhand, 248002, India

    Faculty of Health and Life Sciences, INTI International University, Nilai, 71800, Malaysia

    Published Online:https://doi.org/10.2217/nnm-2022-0117

    Flavonoids represent a major group of polyphenolic compounds. Their capacity to inhibit tumor proliferation, cell cycle, angiogenesis, migration and invasion is substantially responsible for their chemotherapeutic activity against lung cancer. However, their clinical application is limited due to poor aqueous solubility, low permeability and quick blood clearance, which leads to their low bioavailability. Nanoengineered systems such as liposomes, nanoparticles, micelles, dendrimers and nanotubes can considerably enhance the targeted action of the flavonoids with improved efficacy and pharmacokinetic properties, and flavonoids can be successfully translated from bench to bedside through various nanoengineering approaches. This review addresses the therapeutic potential of various flavonoids and highlights the cutting-edge progress in the nanoengineered systems that incorporate flavonoids for treating lung cancer.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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