Effects of silver and gold nanoparticles phytosynthesized with Cornus mas extract on oral dysplastic human cells

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1. Virupakshappa B. Applications of nanomedicine in oral cancer. Oral Health Dent. Manag. 11(2), 62–68 (2012). • This review synthesizes the research studies about the use of nanoparticles in oral cancer.
  MedlineGoogle Scholar
• 2. Shield KD, Ferlay J, Jemal A et al. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA: Cancer J. Clin. 67(1), 51–64 (2017).
  MedlineGoogle Scholar
• 3. Ghantous Y, Abu Elnaaj I. Global incidence and risk factors of oral cancer. Harefuah 156(10), 645–649 (2017).
  MedlineGoogle Scholar
• 4. Azhar N, Sohail M, Ahmad F et al. Risk factors of oral cancer: a hospital based case control study. J. Clin. Exp. Dent. 10(4), e396–e401 (2018).
  MedlineGoogle Scholar
• 5. Niaz K, Maqbool F, Khan F, Bahadar H, Ismail Hassan F, Abdollahi M. Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer. Epidemiol. Health 39, e2017009 (2017).
  MedlineGoogle Scholar
• 6. Poonia M, Ramalingam K, Goyal S, Sidhu SK. Nanotechnology in oral cancer: a comprehensive review. J. Oral Maxillofac. Pathol. 21(3), 407–414 (2017). •• Shows the roles of different nanoparticles in the diagnosis and therapy of oral cancer.
  MedlineGoogle Scholar
• 7. Maman P, Nagpal M, Gilhotra RM, Aggarwal G. Nano era of dentistry: an update. Curr. Drug Deliv. 15(2), 186–204 (2018).
  Medline CASGoogle Scholar
• 8. Filip A, Potara M, Florea A et al. Comparative evaluation by scanning confocal Raman spectroscopy and transmission electron microscopy of therapeutic effects of noble metal nanoparticles in experimental acute inflammation. RSC Adv. 5, 67435–67448 (2015).
  CASGoogle Scholar
• 9. Guo J, Rahme K, He Y, Li LL, Holmes JD, O'Driscoll CM. Gold nanoparticles enlighten the future of cancer theranostics. Int. J. Nanomedicine 12, 6131–6152 (2017).
  Medline CASGoogle Scholar
• 10. Yao C, Zhang L, Wang J et al. Gold nanoparticle mediated phototherapy for cancer. J. Nanomater. 2016, Article ID: 5497136 (2016).
  Google Scholar
• 11. Sanjay Reddy P, Ramaswamy P, Sunanda C, Milanjeet. Role of gold nanoparticles in early detection of oral cancer. JAOMR 22(1), 30–33 (2010).
  Google Scholar
• 12. El-Sayed IH, Huang X, El-Sayed MA. Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer. Nano Lett. 5(5), 829–834 (2005).
  Medline CASGoogle Scholar
• 13. Zhou Y, Kong Y, Kundu S, Cirillo JD, Liang H. Antibacterial activities of gold and silver nanoparticles against Escherichia coli and bacillus Calmette-Guerin. J. Nanobiotechnology 10, 19 (2012).
  Medline CASGoogle Scholar
• 14. Foldbjerg R, Dang DA, Autrup H. Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549. Arch. Toxicol. 85(7), 743–750 (2011).
  Medline CASGoogle Scholar
• 15. Nagalingam M, Kalpana V, Devi Rajeswari V, Panneerselvam A. Biosynthesis, characterization, and evaluation of bioactivities of leaf extract-mediated biocompatible gold nanoparticles from Alternanthera bettzickiana. Biotechnol. Rep. (Amst.) 19, e00268 (2018).
  MedlineGoogle Scholar
• 16. Galluzzi L, Vitale I, Aaronson SA et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 25(3), 486–541 (2018). •• Describes the different types of cell death and their underlining mechanisms.
  MedlineGoogle Scholar
• 17. Singh RP, Ramarao P. Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles. Toxicol. Lett. 213(2), 249–259 (2012).
  Medline CASGoogle Scholar
• 18. De Matteis V, Malvindi MA, Galeone A et al. Negligible particle-specific toxicity mechanism of silver nanoparticles: the role of Ag⁺ ion release in the cytosol. Nanomedicine 11(3), 731–739 (2015).
  MedlineGoogle Scholar
• 19. Mukherjee S, Chowdhury D, Kotcherlakota R et al. Potential theranostics application of bio-synthesized silver nanoparticles (4-in-1 system). Theranostics 4(3), 316–335 (2014).
  Medline CASGoogle Scholar
• 20. Filip GA, Moldovan B, Baldea I et al. UV-light mediated green synthesis of silver and gold nanoparticles using Cornelian cherry fruit extract and their comparative effects in experimental inflammation. J. Photochem. Photobiol. B Biol. 191, 26–37 (2019).
  Medline CASGoogle Scholar
• 21. Khan HA, Abdelhalim MA, Alhomida AS, Al-Ayed MS. Effects of naked gold nanoparticles on proinflammatory cytokines mRNA expression in rat liver and kidney. Biomed. Res. Int. 2013, 590730( 2013).
  MedlineGoogle Scholar
• 22. Abdelhalim MA, Jarrar BM. Renal tissue alterations were size-dependent with smaller ones induced more effects and related with time exposure of gold nanoparticles. Lipids Health Dis. 10, 163 (2011).
  Medline CASGoogle Scholar
• 23. Frankova J, Pivodova V, Vagnerova H, Juranova J, Ulrichova J. Effects of silver nanoparticles on primary cell cultures of fibroblasts and keratinocytes in a wound-healing model. J. Appl. Biomater. Funct. Mater. 14(2), e137–e142 (2016).
  Medline CASGoogle Scholar
• 24. Bhol KC, Schechter PJ. Effects of nanocrystalline silver (NPI 32101) in a rat model of ulcerative colitis. Dig. Dis. Sci. 52(10), 2732–2742 (2007).
  Medline CASGoogle Scholar
• 25. Crisan D, Scharffetter-Kochanek K, Crisan M et al. Topical silver and gold nanoparticles complexed with Cornus mas suppress inflammation in human psoriasis plaques by inhibiting NF-kappaB activity. Exp. Dermatol. 27(10), 1166–1169 (2018).
  Medline CASGoogle Scholar
• 26. Singleton VL, Orthofer R, Lamuela-Raventós RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. In: Methods in Enzymology (Volume 299). Paker L (Ed.). Academic Press, CA, USA, 152–178 (1999).
  Google Scholar
• 27. David L, Moldovan B, Vulcu A et al. Green synthesis, characterization and anti-inflammatory activity of silver nanoparticles using European black elderberry fruits extract. Colloids Surf. B Biointerfaces 122, 767–777 (2014).
  Medline CASGoogle Scholar
• 28. Perde-Schrepler M, David L, Olenic L et al. Gold nanoparticles synthesized with a polyphenols-rich extract from Cornelian cherry (Cornus mas) fruits: effects on human skin cells. J. Nanomater. 2016, 6986370 (2016).
  Google Scholar
• 29. Olteanu D, Baldea I, Clichici S et al. In vitro studies on the mechanisms involved in chemoprevention using Calluna vulgaris on vascular endothelial cells exposed to UVB. J. Photochem. Photobiol. B Biol. 136, 54–61 (2014).
  Medline CASGoogle Scholar
• 30. Baldea I, Olteanu DE, Bolfa P et al. Efficiency of photodynamic therapy on WM35 melanoma with synthetic porphyrins: role of chemical structure, intracellular targeting and antioxidant defense. J. Photochem. Photobiol. B Biol. 151, 142–152 (2015).
  Medline CASGoogle Scholar
• 31. Hu ML. Measurement of protein thiol groups and glutathione in plasma. Methods Enzymol. 233, 380–385 (1994).
  Medline CASGoogle Scholar
• 32. Moldovan B, Sincari V, Perde-Schrepler M, David L. Biosynthesis of silver nanoparticles using Ligustrum ovalifolium fruits and their cytotoxic effects. Nanomaterials 8(8), 627 (2018).
  Google Scholar
• 33. Moldovan B, Popa A, David L. Effects of storage temperature on the total phenolic content of Cornelian cherry (Cornus mas L.) fruits extracts. J. Appl. Bot. Food Qual. 89, 208–211 (2016).
  CASGoogle Scholar
• 34. Moldovan B, David L. Bioactive flavonoids from Cornus mas L. fruits. Mini Rev. Org. Chem. 14, 489–495 (2017).
  CASGoogle Scholar
• 35. Behravan M, Panahi AH, Naghizadeh A, Ziaee M, Mahdavi R, Mirzapour A. Facile green synthesis of silver nanoparticles using Berberis vulgaris leaf and root aqueous extract and its antibacterial activity. Int. J. Biol. Macromol. 124, 148–154 (2019).
  Medline CASGoogle Scholar
• 36. Hirsch LR, Stafford RJ, Bankson JA et al. Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc. Natl Acad. Sci. USA 100(23), 13549–13554 (2003).
  Medline CASGoogle Scholar
• 37. Danila OO, Berghian AS, Dionisie V et al. The effects of silver nanoparticles on behavior, apoptosis and nitro-oxidative stress in offspring Wistar rats. Nanomedicine (Lond.) 12(12), 1455–1473 (2017).
  CASGoogle Scholar
• 38. Gordijn B. Nanoethics: from utopian dreams and apocalyptic nightmares towards a more balanced view. Sci. Eng. Ethics 11(4), 521–533 (2005).
  MedlineGoogle Scholar
• 39. Opris R, Tatomir C, Olteanu D et al. The effect of Sambucus nigra L. extract and phytosinthesized gold nanoparticles on diabetic rats. Colloids Surf. B Biointerfaces 150, 192–200 (2017).
  Medline CASGoogle Scholar
• 40. Antony JJ, Sivalingam P, Chen B. Toxicological effects of silver nanoparticles. Environ. Toxicol. Pharmacol. 40(3), 729–732 (2015).
  Medline CASGoogle Scholar
• 41. Patra HK, Banerjee S, Chaudhuri U, Lahiri P, Dasgupta AK. Cell selective response to gold nanoparticles. Nanomedicine 3(2), 111–119 (2007).
  Medline CASGoogle Scholar
• 42. Zhang XF, Shen W, Gurunathan S. Silver nanoparticle-mediated cellular responses in various cell lines: an in vitro model. Int. J. Mol. Sci. 17(10), E1603 (2016). •• Reviews the effects and mechanisms of action of silver nanoparticles, depending on size, charge and shape in different cell lines, including epithelial cells.
  MedlineGoogle Scholar
• 43. Vijayakumar S, Ganesan S. In vitro cytotoxicity assay on gold nanoparticles with different stabilizing agents. J. Nanomater. Article ID, 734398 (2012).
  Google Scholar
• 44. Pan Y, Neuss S, Leifert A et al. Size-dependent cytotoxicity of gold nanoparticles. Small 3(11), 1941–1949 (2007).
  Medline CASGoogle Scholar
• 45. Gliga AR, Skoglund S, Wallinder IO, Fadeel B, Karlsson HL. Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release. Part. Fibre Toxicol. 11, Article number: 11 (2014).
  Google Scholar
• 46. Khorrami S, Zarrabi A, Khaleghi M, Danaei M, Mozafari MR. Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties. Int. J. Nanomed. 13, 8013–8024 (2018).
  Medline CASGoogle Scholar
• 47. Comfort KK, Maurer EI, Braydich-Stolle LK, Hussain SM. Interference of silver, gold, and iron oxide nanoparticles on epidermal growth factor signal transduction in epithelial cells. ACS Nano 5(12), 10000–10008 (2011). • Demonstrates the inhibition of epidermal growth factor signal transduction by gold and silver nanoparticles in human epidermoid carcinoma cells.
  Medline CASGoogle Scholar
• 48. Chithrani BD, Chan WC. Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett. 7(6), 1542–1550 (2007).
  Medline CASGoogle Scholar
• 49. Stoehr LC, Gonzalez E, Stampfl A et al. Shape matters: effects of silver nanospheres and wires on human alveolar epithelial cells. Part. Fibre Toxicol. 8, 425–430 (2011).
  Google Scholar
• 50. Zhai Y, Hunting ER, Wouters M, Peijnenburg WJ, Vijver MG. Silver nanoparticles, ions, and shape governing soil microbial functional diversity: nano shapes micro. Front. Microbiol. 7, 1123 (2016).
  MedlineGoogle Scholar
• 51. Ostaszewska T, Sliwinski J, Kamaszewski M, Sysa P, Chojnacki M. Cytotoxicity of silver and copper nanoparticles on rainbow trout (Oncorhynchus mykiss) hepatocytes. Environ. Sci. Pollut. Res. Int. 25(1), 908–915 (2018).
  Medline CASGoogle Scholar
• 52. Katsnelson BA, Privalova LI, Gurvich VB et al. Comparative in vivo assessment of some adverse bioeffects of equidimensional gold and silver nanoparticles and the attenuation of nanosilver's effects with a complex of innocuous bioprotectors. Int. J. Mol. Sci. 14(2), 2449–2483 (2013).
  Medline CASGoogle Scholar
• 53. Liu X, Lee PY, Ho CM et al. Silver nanoparticles mediate differential responses in keratinocytes and fibroblasts during skin wound healing. ChemMedChem 5(3), 468–475 (2010).
  Medline CASGoogle Scholar
• 54. Lau P, Bidin N, Islam S et al. Influence of gold nanoparticles on wound healing treatment in rat model: photobiomodulation therapy. Lasers Surg. Med. 49(4), 380–386 (2017).
  MedlineGoogle Scholar
• 55. Pivodova V, Frankova J, Galandakova A, Ulrichova J. In vitro AuNPs' cytotoxicity and their effect on wound healing. Nanobiomedicine (Rij) 2, 7 (2015).
  MedlineGoogle Scholar
• 56. Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL. Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. Oncogene 32(36), 4304–4312 (2013).
  Medline CASGoogle Scholar
• 57. Salvador-Gallego R, Mund M, Cosentino K et al. Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores. EMBO J. 35(4), 389–401 (2016).
  Medline CASGoogle Scholar
• 58. Mcshan D, Ray PC, Yu H. Molecular toxicity mechanism of nanosilver. J. Food Drug Anal. 22(1), 116–127 (2014).
  Medline CASGoogle Scholar
• 59. Yun CW, Lee SH. The roles of autophagy in cancer. Int. J. Mol. Sci. 19(11), E3466 (2018).
  MedlineGoogle Scholar
• 60. Banath JP, Klokov D, Macphail SH, Banuelos CA, Olive PL. Residual gammaH2AX foci as an indication of lethal DNA lesions. BMC Cancer 10, 4 (2010).
  MedlineGoogle Scholar
• 61. May S, Hirsch C, Rippl A et al. Transient DNA damage following exposure to gold nanoparticles. Nanoscale 10(33), 15723–15735 (2018).
  Medline CASGoogle Scholar
• 62. Cardoso E, Rezin GT, Zanoni ET et al. Acute and chronic administration of gold nanoparticles cause DNA damage in the cerebral cortex of adult rats. Mutat. Res. 766–767; 25–30 (2014).
  Google Scholar
• 63. Cardoso E, Londero E, Kozuchovski Ferreira G et al. Gold nanoparticles induce DNA damage in the blood and liver of rats. J. Nanopart. Res. 16, 2727 (2014).
  Google Scholar
• 64. Nallanthighal S, Chan C, Murray TM, Mosier AP, Cady NC, Reliene R. Differential effects of silver nanoparticles on DNA damage and DNA repair gene expression in Ogg1-deficient and wild type mice. Nanotoxicology 11(8), 996–1011 (2017).
  Medline CASGoogle Scholar
• 65. Chatterjee N, Eom HJ, Choi J. Effects of silver nanoparticles on oxidative DNA damage-repair as a function of p38 MAPK status: a comparative approach using human Jurkat T cells and the nematode Caenorhabditis elegans. Environ. Mol. Mutagen. 55(2), 122–133 (2014).
  Medline CASGoogle Scholar
• 66. Grzelak A, Wojewodzka M, Meczynska-Wielgosz S, Zuberek M, Wojciechowska D, Kruszewski M. Crucial role of chelatable iron in silver nanoparticles induced DNA damage and cytotoxicity. Redox Biol. 15, 435–440 (2018). • Demonstrates that the silver nanoparticles toxicity is linked to free radicals induced damage through the Fenton reaction.
  Medline CASGoogle Scholar
• 67. Fehaid A, Taniguchi A. Size-dependent effect of silver nanoparticles on the tumor necrosis factor alpha-induced DNA damage response. Int. J. Mol. Sci. 20(5), E1038 (2019). •• Shows that the oxidative DNA damage induced by TNF-α is modulated by silver nanoparticle size: decreased by small nanoparticles and increased by big nanoparticles, in epithelial lung cells.
  Medline CASGoogle Scholar